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Potential role in vesicular protein trafficking, mainly in the early secretory pathway.
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The luminal alpha-helical but not GOLD domain of p24gamma2 was required for efficient GPI (show GNPDA1 Proteins)-AP transport.
Expression of cgi-100 mRNA decreased in a dose- and time-dependent manner in the K562 cells treated with matrine and over-expression of cgi-100 elevates the proliferation and the immaturity level of K562 cells.
Crystallographic analysis of murine p24gamma2 Golgi dynamics domain has been reported.
Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus\; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle- mediated retrograde transport (By similarity).
p24 family protein gamma-2
, transmembrane emp24 domain-containing protein 5
, p24 family protein gamma 2