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TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009].. Additionally we are shipping TMEM97 Antibodies (29) and TMEM97 Kits (1) and many more products for this protein.
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we not only confirmed the elevated MAC30 mRNA, but also demonstrated that GC with overexpression of MAC30 resisted to adjuvant platinum-based chemotherapy.
TMEM97 possesses the full suite of molecular properties that define the sigma2 receptor, and Asp29 and Asp56 are essential for ligand recognition
MAC30 could be a useful biomarker of tumor differentiation and outcome of patients with non-small cell lung cancer. Overexpression of MAC30 predicts a worse tumor differentiated stage and prognosis in patients with non-small cell lung cancer receiving adjuvant chemotherapy.
Study generated a series of sigma1R (show SIGMAR1 Proteins) and sigma2R/Tmem97 agonists and antagonists and tested them for efficacy in the mouse spared nerve injury model. Results show robust antineuropathic pain effects of sigma1R (show SIGMAR1 Proteins) and sigma2R/Tmem97 ligands, demonstrate that sigma2R/Tmem97 is a novel neuropathic pain target, and identify sigma2R/Tmem97 agonist UKH-1114 as a lead molecule for further development.
knockdown of TMEM97 also increases levels of residual NPC1 (show NPC1 Proteins) in NPC1 (show NPC1 Proteins)-mutant patient fibroblasts and reduces cholesterol storage in an NPC1 (show NPC1 Proteins)-dependent manner. Our findings propose TMEM97 inhibition as a novel strategy to increase residual NPC1 (show NPC1 Proteins) levels in cells and a potential therapeutic target for Niemann-Pick type C disease (NP-C).
Overexpression of MAC30 is associated with Squamous Cell Carcinomas of the Lung.
High expression of TMEM97 is associated with glioma.
The down-regulation of MAC30 expression efficiently inhibited the proliferation of gastric cancer cells. Furthermore, the mobility of gastric cancer cells was also inhibited by down-regulation of MAC30.
MAC30 may serve as a new molecular marker to predict the lymph node metastasis and prognosis of patients with epithelial ovarian cancer
Overexpression of MAC30 is associated with non-small-cell lung cancer.
TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009
transmembrane protein 97
, hypothetical protein LOC569147