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May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. Additionally we are shipping Trichoplein, Keratin Filament Binding Antibodies (50) and Trichoplein, Keratin Filament Binding Proteins (5) and many more products for this protein.
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Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.
These findings underscore the complexity of PGC-1alpha-mediated mitochondrial homeostasis and establish mitostatin as a key regulator of tumor cell mitophagy and angiostasis.
Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.
Trichoplein/mitostatin is a new regulator of mitochondria-endoplasmic reticulum juxtaposition.
MITOSTATIN was found within a 3.2-kb transcript for an approximately 62 kDa mitochondrial protein with tumor suppressor activity. It inhibits cell growth, is proapoptotic and downregulates Hsp27.
trichoplein is a keratin 8/18-binding protein that may be involved in the organization of the apical network of keratin filaments and desmosomes in simple epithelial cells
MITOSTATIN may acts as a tumor suppressor gene in prostate cancer.
May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity).
trichoplein, keratin filament binding
, mitochondrial protein with oncostatic activity
, trichoplein keratin filament-binding protein
, tumor suppressor protein