Tropomodulin 1 (TMOD1) ELISA Kits

TMOD1 encodes a member of the tropomodulin family. Additionally we are shipping Tropomodulin 1 Antibodies (66) and Tropomodulin 1 Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
TMOD1 7111 P28289
Anti-Mouse TMOD1 TMOD1 21916 P49813
Anti-Rat TMOD1 TMOD1 25566  
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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests 15 to 18 Days

More ELISA Kits for Tropomodulin 1 Interaction Partners

Human Tropomodulin 1 (TMOD1) interaction partners

  1. Tmod1 function in mouse and human erythroblasts, was investigated.

  2. The mutation reduced binding affinity for both Lmod2 and Tmod1. The effect of the K15N mutation on Tpm1.1 binding to Lmod2 and Tmod1 provides a molecular rationale for the development of familial dilated cardiomyopathies .

  3. Study highlighted a novel TMOD1-mediated link between NF-kappaB activation and MMP13 induction, which accounts in part for the NF-kappaB-dependent malignant phenotype of TNBC.

  4. Tmod1 and Tmod3 showed somewhat different tropomyosin-binding site utilization.

  5. The structures and biochemical analysis of structure-inspired mutants showed that one Tmod molecule interacts with three actin subunits at the pointed end, while also contacting two tropomyosin molecules on each side of the filament.

  6. Tropomyosin requires an intact N-terminal coiled coil to interact with this protein

  7. levels of TM1, TM2 and TM3 are reduced in human transitional cell carcinoma cells, but significantly upregulated by inhibition of the mitogen-activated protein kinase-signaling pathway

  8. The N-terminal "KRK ring" may participate in balancing electrostatic force with hydrophobic interaction in dimerization of TM and its binding to E-Tmod.

  9. study identifies several amino acid residues on Tmod-1 that are important for its interaction with TM5 (a nonmuscle TM isoform)

Mouse (Murine) Tropomodulin 1 (TMOD1) interaction partners

  1. Tmod1 function in mouse and human erythroblasts, was investigated.

  2. distinct F-actin organizations are present in small protrusions versus large paddles. Formation and/or maintenance of large paddle domains depends on a beta2-spectrin-actin network stabilized by Tmod1. alpha-Actinin-crosslinked F-actin bundles are enhanced in absence of Tmod1, indicating altered cytoskeleton organization.

  3. TMOD1 expression was upregulated significantly (p<0.05) in OSCC.

  4. RNAi depletion of Tmod1 from either wild-type or Tmod4(-/-) muscle fibers leads to thin filament elongation by approximately 15%.

  5. The C-terminal extension of Lmod2 and C terminal of Tmod1 are sufficient to produce a filament nucleator.

  6. Calpain-mediated proteolysis of tropomodulin isoforms TMOD1 and TMOD4 leads to thin filament elongation in dystrophic skeletal muscle.

  7. Role of Tmod1 protein's leucine rich repeat domain in the formation of neurite-like processes

  8. Tmods are novel regulators of actomyosin crossbridge formation and muscle contractility, and future investigations and models of skeletal muscle force production must incorporate Tmods.

  9. Tmod1 is involved in a functional synergy critical for regulating lens fiber cell geometry, transparency, and mechanical stiffness.

  10. Tropomodulin 1 constrains fiber cell geometry during elongation and maturation in the lens cortex.

  11. The Tmod1 deletion caused Tmod3 to leave its SR compartment, leading to mislocalization and destabilization of the Tmod3-gamma(cyto)-actin-sAnk1.5 complex.

  12. Tmod1-null mice display a mild anemia with features resembling hereditary spherocytic elliptocytosis.

  13. Erythrocyte tropomodulin isoforms with and without the N-terminal actin-binding domain.

  14. Tmod1 is a novel regulator of skeletal muscle physiology.

  15. Data suggest that tropomodulin 1 is required for regulation of actin filament lengths and myofibril maturation, which is critical for heart morphogenesis during embryonic development.

  16. Tmod may be involved in the differentiation process in myogenic cells

  17. Disruption in the tropomodulin1 (Tmod1) gene compromises cardiomyocyte development in murine embryonic stem cells by arresting myofibril maturation.

  18. Cloning and analysis of the putative Tmod1 promoter show that two conserved sequences, one in the 5'-end of the first exon and the other in the intron next to the first exon, are necessary for the basal promoter activity.

  19. In adults, expression is restricted to the olfactory bulb, hippocampus, cerebral cortex, basal ganglia, nuclei of brain stem and cerebellum. In neonates, signals in the cortex and caudate putamen increased from days 15 to 40.

  20. Tmod1 is not required in erythrocytes for viability, nor do the Tmod1 knockout fragile primitive erythroid cells affect cardiac development, yolk sac vasculogenesis, or viability in the mouse.

Tropomodulin 1 (TMOD1) Antigen Profile

Antigen Summary

This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with Tropomodulin 1 (TMOD1) ELISA Kits

  • tropomodulin 1 (TMOD1) antibody
  • tropomodulin 1 (tmod1) antibody
  • tropomodulin 1 (Tmod1) antibody
  • D9S57E antibody
  • E-Tmod antibody
  • ETMOD antibody
  • si:ch211-288h2.6 antibody
  • Tmod antibody
  • TMOD1 antibody
  • tropomodulin-1 antibody

Protein level used designations for Tropomodulin 1 (TMOD1) ELISA Kits

tropomodulin-1 , tropomodulin 1 , tropomodulin-1-like , E-Tmod , e-tropomodulin , erythrocyte tropomodulin , E-Tropomodulin

395883 Gallus gallus
464599 Pan troglodytes
474771 Canis lupus familiaris
715838 Macaca mulatta
100149766 Danio rerio
100316850 Sus scrofa
100397199 Callithrix jacchus
100443166 Pongo abelii
100588809 Nomascus leucogenys
7111 Homo sapiens
21916 Mus musculus
25566 Rattus norvegicus
780784 Bos taurus
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