Troponin I Type 3 (Cardiac) (TNNI3) ELISA Kits

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. Additionally we are shipping Troponin I Type 3 (Cardiac) Antibodies (866) and Troponin I Type 3 (Cardiac) Proteins (38) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
TNNI3 7137 P19429
TNNI3 21954 P48787
TNNI3 29248 P23693
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Top Troponin I Type 3 (Cardiac) ELISA Kits at antibodies-online.com

Showing 10 out of 129 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Rat 13.5 pg/mL 31.2 pg/mL - 2000 pg/mL 96 Tests Log in to see 13 to 16 Days
$720.00
Details
Human 11.9 pg/mL 31.2 pg/mL - 2000 pg/mL 96 Tests Log in to see 13 to 16 Days
$589.47
Details
Rabbit 11.75 pg/mL 47-3000 pg/mL Typical standard curve 96 Tests Log in to see 13 to 16 Days
$1,107.33
Details
Mouse 11.4 pg/mL 31.2 pg/mL - 2000 pg/mL 96 Tests Log in to see 13 to 16 Days
$682.11
Details
Pig 12.3 pg/mL 31.2 pg/mL - 2000 pg/mL 96 Tests Log in to see 13 to 16 Days
$795.79
Details
Cow 0.75 ng/mL 0.6-30 ng/mL Typical standard curve 96 Tests Log in to see 13 to 16 Days
$1,026.67
Details
Pig 18.75 pg/mL 31.25-2000 pg/mL Typical standard curve 96 Tests Log in to see 12 to 14 Days
$616.00
Details
Guinea Pig 1.0 pg/mL 25-500 pg/mL   96 Tests Log in to see 15 to 18 Days
$707.14
Details
Chicken 9.4 pg/mL 15.6 pg/mL - 1000 pg/mL A typical standard curve 96 Tests Log in to see 13 to 16 Days
$601.54
Details
Sheep
96 Tests Log in to see 15 to 18 Days
$707.14
Details

Top referenced Troponin I Type 3 (Cardiac) ELISA Kits

  1. Rat (Rattus) TNNI3 ELISA Kit for Sandwich ELISA - ABIN368254 : Jin, Wang, Wang, Zhang, Yan, Hu: Effects of acetaldehyde and L-carnitine on morphology and enzyme activity of myocardial mitochondria in rats. in Molecular biology reports 2015 (PubMed)
    Show all 4 Pubmed References

  2. Rat (Rattus) TNNI3 ELISA Kit for Sandwich ELISA - ABIN416120 : Chai, Liu, Hu: Comparison of femoral and aortic remote ischaemia preconditioning for cardioprotection against myocardial ischaemia/reperfusion injury in a rat model. in Interactive cardiovascular and thoracic surgery 2014 (PubMed)
    Show all 2 Pubmed References

  3. Human TNNI3 ELISA Kit for Sandwich ELISA - ABIN454654 : Bu, Zhao, Ma, Han, Yang, Shi, Liu, Fang, Wang, Ma, Hu, Yang, Li, Liu, Nie, Zhou: Protective role of statins in patients with acute coronary syndrome aged ? 75 years with low LDL-C who underwent percutaneous coronary intervention. in Angiology 2015 (PubMed)

  4. Mouse (Murine) TNNI3 ELISA Kit for Sandwich ELISA - ABIN1000107 : Jia, Hao, Guo: Ultrafine carbon black disturbs heart rate variability in mice. in Toxicology letters 2012 (PubMed)

  5. Rat (Rattus) TNNI3 ELISA Kit for Sandwich ELISA - ABIN2685773 : Li, Lu, Luo, Li, Chen: High association between human circulating microRNA-497 and acute myocardial infarction. in TheScientificWorldJournal 2014 (PubMed)

  6. Human TNNI3 ELISA Kit for Sandwich ELISA - ABIN415010 : Khanaghaei, Tourkianvalashani, Hekmatimoghaddam, Ghasemi, Rahaie, Khorramshahi, Sheikhpour, Heydari, Pourrajab: Circulating miR-126 and miR-499 reflect progression of cardiovascular disease; correlations with uric acid and ejection fraction. in Heart international 2016 (PubMed)

More ELISA Kits for Troponin I Type 3 (Cardiac) Interaction Partners

Human Troponin I Type 3 (Cardiac) (TNNI3) interaction partners

  1. Data show that the incident atrial fibrillation (AF) occurrence group had similar baseline troponin I (TnI) levels, but higher troponin T (TnT) levels [Review and Meta-Analysis].

  2. Studies indicate that in patients with end-stage renal disease (ESRD), elevation of cardiac-specific troponin T (cTnT) was more frequent than elevation of troponin I (cTnI) [Review].

  3. the frequency of h-FABP positivity among acute myocardial infarction patients was higher than that of hs-TnI, which would have missed six of them; however, hs-TnI area under curve was superior to that of h-FABP.

  4. Reversible Covalent Reaction of Levosimendan with Cardiac Troponin C in Vitro and in Situ.

  5. Mutations in genes encoding cardiac troponin I (TNNI3) and cardiac troponin T (TNNT2) caused altered troponin protein stoichiometry in patients with dilated cardiomyopathy. TNNI3p.98trunc resulted in haploinsufficiency, increased Ca(2+) -sensitivity and reduced length-dependent activation. TNNT2p.K217del caused increased passive tension.

  6. The QT interval has a strong positive linear correlation with cardiac troponin-I levels in Non-ST-elevation myocardial infarction.

  7. Apelin-12 influences troponin I levels in the acute phase of STEMI, whereas during the non-acute phase, low apelin levels were associated with a high rate of MACE.

  8. In clinical stable patients without known cardiovascular disease, a thorough chest-pain history in combination with hs-TnI testing can identify a significant low-risk group.

  9. Study showed that in patients who underwent liver transplantation elevation of preoperative high-sensitivity cardiac troponin I level was associated with 1-year mortality and 30-day mortality.

  10. Serial measurement of troponin I revealed a persistent elevation in patients with diabetes mellitus type 2.

  11. Plasma troponin C1 (cTnI) is biomarker of choice for diagnosing acute myocardial infarction (AMI) because of its high specificity as biomarker for damage to myocardial tissue. Data suggest the "best cut-off" for plasma cTnI is 0.014 micrograms/L in AMI. These studies were conducted in emergency department of a university hospital in Italy using point-of-care testing in patients presenting with chest pain, ages 18-101.

  12. NT-proBNP and hs-cTnI levels were higher in systemic sclerosis patients than controls. Both NT-proBNP and hs-cTnI were associated with the presence of echocardiographic abnormalities.

  13. value of cTnI level assessed 24 hours post-surgery was a reliable predictor of death following liver transplantation with optimal cut-off value of 0.215 ng/mL. The surgery time was the most important predictor of cTnI elevation.

  14. cTnI levels are common in Fabry disease patients, reflecting cardiac involvement.

  15. Report novel troponin I rule-out value below the upper reference limit for acute myocardial infarction.

  16. cTnI determined in hemodynamically stable patients with suspected AMI and wide QRS complex using optimized diagnostic thresholds improves rule-in and rule-out with respect to presence of a significant obstructive CAD

  17. 83 preterm infants with Bronchopulmonary dysplasia born <28-wk gestation and still inpatients at 36-wk corrected age received an echocardiogram and blood tests of B-type natriuretic peptide (BNP), troponin I, and YKL-40.

  18. Serum cardiac troponin I was increased in septic patients with myocardial depression compared to those without myocardial depression.

  19. Elevated BNP and hs-cTnI after kidney transplantation identify candidates for targeted risk reduction.

  20. These perturbed biophysical and biochemical myofilament properties are likely to significantly contribute to the diastolic cardiac pump dysfunction that is seen in patients suffering from a restrictive cardiomyopathy that is associated with the cTnI R145W mutation.

Mouse (Murine) Troponin I Type 3 (Cardiac) (TNNI3) interaction partners

  1. Pim-1 is a novel kinase that phosphorylates cTnI primarily at Ser23/24 and Ser150 in cardiomyocytes, which in turn may modulate myofilament function under a variety of physiological and pathophysiological conditions.

  2. Hyperphosphorylation of this serine199 in cTnI C terminus impacts heart function by depressing diastolic function at baseline and limiting systolic reserve under physiological stresses. Paradoxically, it preserves heart function after ischemia/reperfusion injury, potentially by decreasing proteolysis of cTnI.

  3. The contributions of cardiac myosin binding protein C and troponin I phosphorylation to beta-adrenergic enhancement of in vivo cardiac function

  4. The difference in myosin regulatory light chain phosphorylation between the ventricles of R21C(+/+) in cardiac troponin I mice likely contributes to observed differences in contractile force and the lower tension monitored in the LV of HCM mice

  5. troponin I phosphorylation specifically alters the Ca(2+) sensitivity of isometric tension and the time course of relaxation in cardiac muscle myofibrils

  6. Combined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca(2+) sensitivity playing an adaptive role to preserve contraction during acidic ischemia.

  7. these results indicate that the inability to enhance myofilament relaxation through cTnI phosphorylation predisposes the heart to abnormal diastolic function, reduced accessibility of cardiac reserves, dysautonomia, and hypertrophy.

  8. Dominant negative TnI-TnT interface mutation decreases the binding affinity of cTnI for TnT, causes early ventricular remodeling, and blunts the beta-adrenergic response of cardiac myocytes.

  9. R193H and R205H mutation increase the binding affinity of Troponin I for Troponin T and Troponin C.

  10. Conclude that dilated cardiomyopathy-causing mutations in thin filament proteins abolish the relationship between myofilament Ca(2+) sensitivity and troponin I phosphorylation by PKA.

  11. The pattern of cTnI post-translational modification depends on sex and hypertrophic cardiomyopathy genotype.

  12. A new functional and pathological role of amino acid modifications in the N-terminal acidic domain of cardiac TnI has been found that is modified by phosphorylations at TnI(S23/S24).

  13. Data show that cardiac TnI gene transition and the alternatively spliced cardiac TnT isoform switching occur in postnatal pulmonary vein.

  14. Conclude that cTnI phosphorylation by AMPK may represent a novel mechanism of regulation of cardiac function.

  15. Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy.

  16. Data suggest that AMPK emerges as a possibly important regulator of cardiac and skeletal contractility via phosphorylation of a preferred site adjacent to the inhibitory loop of the thin filament protein TnI.

  17. Loss of troponin I leads to myofibril hypersensitivity to Ca(2+) causing impaired relaxation in restrictive cardiomyopathy.

  18. the functional effect of cTnI mutation and its potential value in compensating for the cTnT abnormality

  19. Ca(2+) binding to thin filaments reconstituted with either cTnI(wild-type) or pseudo-phosphorylated cTnI(S23D/S24D), cTnI(T144E), and cTnI(S23D/S24D/T144E) was determined.

  20. Studies indicate that that immunization of genetically susceptible mice with troponin I but not troponin T induced a robust autoimmune response leading to marked inflammation and fibrosis in the myocardium.

Cow (Bovine) Troponin I Type 3 (Cardiac) (TNNI3) interaction partners

  1. An Ala8Val mutation enhances the effect of cardiac troponin I pseudophosphorylation on the rate of dissociation of calcium from reconstituted thin filaments.

  2. Serum cardiac troponin I cannot be used to distinguish cattle with pericarditis from cattle with other primary cardiac diseases or noncardiac, intrathoracic disorders.

Horse (Equine) Troponin I Type 3 (Cardiac) (TNNI3) interaction partners

  1. Cardiac ANP was increased in horses with mitral regurgitation (MR) and cardiac troponin levels were low in healthy and MR affected horses.

Pig (Porcine) Troponin I Type 3 (Cardiac) (TNNI3) interaction partners

  1. We show that the phosphorylation of cTnI and alphaTm vary in the different chambers of the heart, whereas the phosphorylation of MLC2 and cTnT does not.

  2. hFABP rises faster and correlates better with infarct size and no-reflow than hsTnI in myocardial infarction + reperfusion when measured early after reperfusion.

  3. analysis of expression profiling of porcine troponin I family in three different types of muscles during development

  4. nucleotide sequence, genomic structure, and tissue expression

Rainbow Trout (Oncorhynchus mykiss) Troponin I Type 3 (Cardiac) (TNNI3) interaction partners

  1. By replacing rat cardiac troponin I (cTnI) in a mammalian cTn complex with trout cTnI it was demonstrated that this protein increases the Ca2+ affinity and reduces the influence of PKA phosphorylation on the Ca2+ affinity of the cTn complex.

Troponin I Type 3 (Cardiac) (TNNI3) Antigen Profile

Antigen Summary

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit\; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Gene names and symbols associated with TNNI3

  • troponin I3, cardiac type (TNNI3) antibody
  • troponin I, cardiac 3 (Tnni3) antibody
  • troponin I type 3 (cardiac) (TNNI3) antibody
  • troponin I3, cardiac type S homeolog (tnni3.S) antibody
  • troponin I3, cardiac type L homeolog (tnni3.L) antibody
  • troponin I3, cardiac type (tnni3) antibody
  • cardiac troponin I (LOC100462680) antibody
  • troponin I3, cardiac type (Tnni3) antibody
  • c-troponin antibody
  • CMD1FF antibody
  • CMD2A antibody
  • cmh7 antibody
  • cTNI antibody
  • ctnIc antibody
  • cTNT antibody
  • RCM1 antibody
  • Tn1 antibody
  • TnI antibody
  • TnIc antibody
  • tnnc1 antibody
  • TNNI3 antibody
  • XTnIc antibody

Protein level used designations for TNNI3

troponin I, cardiac muscle , cardiac troponin I , troponin IC , troponin I type 3 (cardiac) , cardiac tropin T , troponin I, cardiac , troponin 1, type 3

GENE ID SPECIES
7137 Homo sapiens
21954 Mus musculus
396428 Gallus gallus
397803 Xenopus laevis
403566 Canis lupus familiaris
494826 Xenopus laevis
496889 Xenopus (Silurana) tropicalis
511094 Bos taurus
100034065 Equus caballus
100049696 Sus scrofa
100462680 Oncorhynchus mykiss
698470 Macaca mulatta
29248 Rattus norvegicus
493744 Felis catus
101121961 Ovis aries
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