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Tubulin is the major constituent of microtubules.
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TUBB8 mutations occur in a high proportion of infertile women with oocyte maturation arrest.
The results not only emphasize the important role of TUBB8 in oocyte maturation, fertilization and early embryonic development but they also provide a basis for determining the genetic variations in TUBB8 as a potential additional criterion for evaluating the quality of patients' functional PB1 (show SMR3A Proteins) oocytes.
9 novel TUBB8 mutations and phenotypes in patients with oocyte maturation arrest were reported.
TUBB8 mutations have dominant-negative effects that disrupt microtubule behavior and oocyte meiotic spindle assembly and maturation, causing female infertility.
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
HSA10p15 beta-tubulin 4Q
, class VIII beta-tubulin
, tubulin beta-8 chain