anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) Antibodies

The protein encoded by TNFRSF9 is a member of the TNF-receptor superfamily. Additionally we are shipping CD137 Proteins (74) and CD137 Kits (35) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TNFRSF9 3604 Q07011
TNFRSF9 21942 P20334
TNFRSF9    
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Top anti-CD137 Antibodies at antibodies-online.com

Showing 10 out of 310 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB 100 μL Log in to see 3 to 7 Days
$329.45
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Goat Un-conjugated Agon, CyTOF, FACS, IHC, WB 4-1BB/TNFRSF9/CD137 in Mouse Spleen. 4-1BB/TNFRSF9/CD137 was detected in perfusion fixed frozen sections of mouse spleen using Goat Anti-Mouse 4-1BB/TNFRSF9/CD137 Antigen Affinity-purified Polyclonal Antibody  at 1.7 ug/mL overnight at 4 ᄚC. Tissue was stained using the Anti-Goat HRP-DAB Cell & Detection of Mouse 4-1BB/TNFRSF9/ CD137 by Western Blot. Western blot shows lysates of NS0 mouse myeloma cell line either mock transfected or transfected with recombinant mouse 4-1BB/Fc chimera. PVDF membrane was probed with 0.5 ug/mL of Goat Anti-Mouse 4-1BB/TNFRSF9/CD137 Antigen Affinity-purified Polyclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8 to 9 Days
$416.97
Details
Mouse Rat Biotin FACS   0.1 mg Log in to see 15 to 18 Days
$240.18
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from K562 cells, using TNFRSF9 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse PE-Cy7 ELISA 100 Tests Log in to see 10 to 12 Days
$321.72
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Rat Marrow Tissue; Lane2: Rat Thymus Tissue. 100 μg Log in to see 15 to 18 Days
$332.00
Details
Human Rabbit Un-conjugated ELISA, IF, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Mouse APC FACS 100 Tests Log in to see 10 to 12 Days
$327.56
Details
Human Rabbit Un-conjugated IC, IF, WB   200 μL Log in to see 13 to 14 Days
$487.50
Details

Top referenced anti-CD137 Antibodies

  1. Mouse (Murine) Monoclonal CD137 Primary Antibody for FACS - ABIN2688964 : Chalupny, Peach, Hollenbaugh, Ledbetter, Farr, Aruffo: T-cell activation molecule 4-1BB binds to extracellular matrix proteins. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 11 Pubmed References

  2. Mouse (Murine) Monoclonal CD137 Primary Antibody for FACS, IP - ABIN1177287 : DeBenedette, Chu, Pollok, Hurtado, Wade, Kwon, Watts: Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP. in The Journal of experimental medicine 1995 (PubMed)
    Show all 11 Pubmed References

  3. Human Monoclonal CD137 Primary Antibody for ELISA - ABIN2688961 : Kim, Broxmeyer: Therapeutic potential of 4-1BB (CD137) as a regulator for effector CD8(+) T cells. in Journal of hematotherapy & stem cell research 2001 (PubMed)
    Show all 4 Pubmed References

  4. Human Monoclonal CD137 Primary Antibody for ELISA - ABIN2688963 : Melero, Shuford, Newby, Aruffo, Ledbetter, Hellström, Mittler, Chen: Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. in Nature medicine 1997 (PubMed)
    Show all 4 Pubmed References

  5. Human Monoclonal CD137 Primary Antibody for Func, FACS - ABIN2749106 : Bellarosa, Bressan, Bigioni, Parlani, Maggi, Binaschi: SAHA/Vorinostat induces the expression of the CD137 receptor/ligand system and enhances apoptosis mediated by soluble CD137 receptor in a human breast cancer cell line. in International journal of oncology 2013 (PubMed)
    Show all 4 Pubmed References

  6. Human Monoclonal CD137 Primary Antibody for Func, FACS - ABIN610408 : Boulton, Cobb: Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. in Cell regulation 1991 (PubMed)
    Show all 4 Pubmed References

  7. Human Polyclonal CD137 Primary Antibody for Agon, CyTOF - ABIN5012831 : Maerten, Geboes, De Hertogh, Shen, Cadot, Bullens, Van Assche, Penninckx, Rutgeerts, Ceuppens: Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's disease. in Clinical immunology (Orlando, Fla.) 2004 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal CD137 Primary Antibody for FACS - ABIN2688962 : Zhou, Kim, Hurtado, Lee, Kim, Pollok, Kwon: Characterization of human homologue of 4-1BB and its ligand. in Immunology letters 1995 (PubMed)
    Show all 3 Pubmed References

  9. Human Monoclonal CD137 Primary Antibody for Func, FACS - ABIN2749216 : Fernández Do Porto, Jurado, Pasquinelli, Alvarez, Aspera, Musella, García: CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis. in Immunology and cell biology 2012 (PubMed)
    Show all 3 Pubmed References

  10. Human Monoclonal CD137 Primary Antibody for Func, FACS - ABIN2800694 : Yi, Zhao, Wang, Dai, Hellström, Hellström, Zhang: Human and mouse CD137 have predominantly different binding CRDs to their respective ligands. in PLoS ONE 2014 (PubMed)
    Show all 3 Pubmed References

More Antibodies against CD137 Interaction Partners

Human Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) interaction partners

  1. structural and functional properties of both h4-1BB and h4-1BBL and reveals that covalent receptor dimerization amplifies h4-1BB signaling

  2. 3 SNPs (rs161827, rs161818, and rs161810) of the CD137 gene and their association with ischemic stroke were studied in a northern Chinese Han population. rs161827 was significantly different between patients with and without diabetes and the controls. rs161818 and rs161810 differed significantly between patients without diabetes and the controls. All 3 were statistically significant in the combination stroke group.

  3. Herein, we present LOAd703, a designed adenovirus armed with trimerized CD40L and 4-1BBL that activates the CD40 and 4-1BB pathways, respectively

  4. Tonic 4-1BB costimulation in chimeric antigen receptors impedes T cell survival and is vector-dependent.

  5. Cetuximab-mediated NK-cell expression of CD137 on tumor-infiltrating lymphocytes is dependent on FcgammaRIIIa polymorphism. In neoadjuvant cetuximab-treated patients with head and neck cancer, upregulation of CD137 by intratumoral, cetuximab-activated NK cells correlated with FcgammaRIIIa V/F polymorphism and predicted clinical response.

  6. In this study we systematically evaluated a series of CAR constructs targeting glypican-3 (GPC3), which is selectively expressed on several solid tumors. We compared GPC3-specific CARs that encoded CD3zeta (Gz) alone or with costimulatory domains derived from CD28 (G28z), 4-1BB (GBBz), or CD28 and 4-1BB (G28BBz).

  7. 4-1BB and 4-1BBL qualify as markers for prediction of patients' course and represent a valuable screening target for patients with acute myeloid leukemia at initial diagnosis.

  8. the role of CD137-CRDI (cysteine rich domain I) in the binding of CD137-CD137L was further investigated.

  9. Egr2-driven cell surface proteins LAG-3 and 4-1BB can identify dysfunctional tumor antigen-specific CD8(+) TIL.

  10. Findings indicate that CD137 antigen is a useful marker that can be used for identifying Mycobacterium tuberculosis (Mtb)-reactive CD4(+) T cells (Mtb-reactive CD4(+) T cells) by flow cytometry.

  11. Anti-4-1BB single chain variable fragments enhanced surface CD69 expression and interleukin-2 production in stimulated CCRF-CEM cells which confirmed the agonistic effect of the selected single chain variable fragments. The data from this study have provided a rationale for further experiments involving the biological functions of anti-4-1BB single chain variable fragments in future studies.

  12. Studies suggest that adoptive T cell therapy and CD137 antigen offer much opportunity to raise the efficacy of current cancer immunotherapies.

  13. Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2.

  14. in complex with T cell receptor, promotes memory T cells, cell respiration, fatty acid oxidation and mitochondrial biogenesis

  15. These studies provide the first direct evidence that ligation of tumour necrosis factor superfamily members and their cognate receptors is important for the control of viral lytic replication.

  16. Our findings provide a novel, TNFRSF9-positive, reactive astrocytic phenotype in human gliomas

  17. Human genetic evidence for involvement of CD137 in atherosclerosis

  18. As a result of becoming activated, transferred human T lymphocytes express the inducible surface antigens hPD-1 and hCD137 on their plasma membrane.

  19. Our results provide biological explanations for the antitumor effects of CD19 CARs and for the observations that CD19 CAR T cells incorporating the 4-1BB costimulatory domain are more persistent than those incorporating CD28 in clinical trials.

  20. upregulation of CD137 expression through LMP1 by EBV promotes cell survival in T or NK cells

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) interaction partners

  1. m4-1BBL and Gal-9 act together to aid aggregation of m4-1BB monomers to efficiently initiate m4-1BB signaling.

  2. the CD137-CD137L pathway plays an important role in regulating VSMC phenotype transformation via activation of NFATc1 signaling pathway.

  3. Tonic 4-1BB costimulation in chimeric antigen receptors impedes T cell survival and is vector-dependent.

  4. fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8(+) T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells.

  5. CD137 signaling activates the pro-angiogenic Smad1/5 pathway, induces the phosphorylation of Smad1/5 and nuclear translocation of p-Smad1/5, which in turn promotes the expression and translocation of NFATc1. Blocking CD137 signaling with inhibitory anti-CD137 antibody could inhibit this activation and attenuated agonist anti-CD137 antibody-induced angiogenesis.

  6. the role of CD137-CRDI (cysteine rich domain I) in the binding of CD137-CD137L was further investigated.

  7. Data indicate that anti-CD137 agonists can function as inhibitors of CD137L signaling, resulting in the creation of tumor microenvironments unfavorable for tumor immune evasion.

  8. These studies reveal that the costimulatory effects of TLR1-TLR2 signaling in CD8(+) T cells are in part mediated by 4-1BB and are important for mounting an effective antitumor immune response.

  9. This study discovers the 4-1BB pathway signaling enhances inflammatory response and promotes pulmonary fibrosis induced by crystalline silica.

  10. Constitutive interaction between 4-1BB and 4-1BBL on murine LPS-activated bone marrow dendritic cells masks detection of 4-1BBL by TKS-1 but not 19H3 antibody.

  11. results indicate that one important diabetogenic function of CD137 is to promote the expansion and accumulation of beta cell-autoreactive CD8 T cells, and in the absence of CD137 or its interaction with CD137 ligand, type 1 diabetes progression is suppressed

  12. High CD137 expression is associated with neoplasms.

  13. Ly6C, 4-1BB, and KLRG1 have roles in the activation of lamina propria lymphocytes in the small intestine in a mouse model of Crohn's disease

  14. CD137 Regulates NFATc1 Expression in Mouse VSMCs through TRAF6/NF-kappaB p65 Signaling Pathway.

  15. 4-1BB triggering preferentially enhances the expansion of CD8+ T cells through the amplification of autocrine IL-2/IL-2R signaling loop.

  16. c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival.

  17. we conclude that in vivo 4-1BB signaling of myeloid cells negatively regulates peripheral T cell responses

  18. activation of CD137 signaling decreases the stability of advanced atherosclerotic plaques via its combined effects on Teff cells, vascular smooth muscle cells, and macrophages

  19. 4-1BB mediates the inflammatory responses in obese skeletal muscle by interacting with its ligand 4-1BBL on macrophages.

  20. CD137-CD137L interactions mediated via regulation of CyPA contribute to the progression of atherosclerosis.

CD137 (TNFRSF9) Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Gene names and symbols associated with TNFRSF9

  • tumor necrosis factor receptor superfamily member 9 (TNFRSF9) antibody
  • TNF receptor superfamily member 9 (TNFRSF9) antibody
  • tumor necrosis factor receptor superfamily, member 9a (tnfrsf9a) antibody
  • tumor necrosis factor receptor superfamily, member 9 (Tnfrsf9) antibody
  • 4-1BB antibody
  • A930040I11Rik antibody
  • AA408498 antibody
  • AI325004 antibody
  • Cd137 antibody
  • CDw137 antibody
  • ILA antibody
  • Ly63 antibody
  • TNFRSF9 antibody
  • zgc:136557 antibody

Protein level used designations for TNFRSF9

tumor necrosis factor receptor superfamily, member 9 , tumor necrosis factor receptor superfamily member 9 , 4-1BB ligand receptor , CD137 antigen , T cell antigen ILA , T-cell antigen 4-1BB homolog , T-cell antigen ILA , homolog of mouse 4-1BB , induced by lymphocyte activation (ILA) , interleukin-activated receptor, homolog of mouse Ly63 , receptor protein 4-1BB , T-cell antigen 4-1BB , secreted CD137 antigen

GENE ID SPECIES
419365 Gallus gallus
520341 Bos taurus
608274 Canis lupus familiaris
678622 Danio rerio
708281 Macaca mulatta
746029 Pan troglodytes
100196937 Papio anubis
100348914 Oryctolagus cuniculus
3604 Homo sapiens
21942 Mus musculus
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