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The protein encoded by TNFRSF9 is a member of the TNF-receptor superfamily. Additionally we are shipping CD137 Proteins (65) and CD137 Kits (30) and many more products for this protein.
Showing 10 out of 329 products:
Mouse (Murine) Monoclonal CD137 Primary Antibody for FACS, IP - ABIN1177287 : Chalupny, Peach, Hollenbaugh, Ledbetter, Farr, Aruffo: T-cell activation molecule 4-1BB binds to extracellular matrix proteins. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed) Show all 11 Pubmed References
Mouse (Murine) Monoclonal CD137 Primary Antibody for FACS - ABIN2688964 : DeBenedette, Chu, Pollok, Hurtado, Wade, Kwon, Watts: Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP. in The Journal of experimental medicine 1995 (PubMed) Show all 11 Pubmed References
Human Monoclonal CD137 Primary Antibody for Func, FACS - ABIN610408 : Boulton, Cobb: Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. in Cell regulation 1991 (PubMed) Show all 4 Pubmed References
Human Monoclonal CD137 Primary Antibody for ELISA - ABIN2688961 : Kim, Broxmeyer: Therapeutic potential of 4-1BB (CD137) as a regulator for effector CD8(+) T cells. in Journal of hematotherapy & stem cell research 2001 (PubMed) Show all 4 Pubmed References
Human Monoclonal CD137 Primary Antibody for ELISA - ABIN2688963 : Melero, Shuford, Newby, Aruffo, Ledbetter, Hellström, Mittler, Chen: Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. in Nature medicine 1997 (PubMed) Show all 4 Pubmed References
Human Monoclonal CD137 Primary Antibody for Func, FACS - ABIN2749106 : Bellarosa, Bressan, Bigioni, Parlani, Maggi, Binaschi: SAHA/Vorinostat induces the expression of the CD137 receptor/ligand system and enhances apoptosis mediated by soluble CD137 receptor in a human breast cancer cell line. in International journal of oncology 2013 (PubMed) Show all 4 Pubmed References
Human Polyclonal CD137 Primary Antibody for Agon, CyTOF - ABIN5012831 : Maerten, Geboes, De Hertogh, Shen, Cadot, Bullens, Van Assche, Penninckx, Rutgeerts, Ceuppens: Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's disease. in Clinical immunology (Orlando, Fla.) 2004 (PubMed) Show all 3 Pubmed References
Human Monoclonal CD137 Primary Antibody for FACS - ABIN2688962 : Zhou, Kim, Hurtado, Lee, Kim, Pollok, Kwon: Characterization of human homologue of 4-1BB and its ligand. in Immunology letters 1995 (PubMed) Show all 3 Pubmed References
Human Monoclonal CD137 Primary Antibody for Func, FACS - ABIN2800694 : Fernández Do Porto, Jurado, Pasquinelli, Alvarez, Aspera, Musella, García: CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis. in Immunology and cell biology 2012 (PubMed) Show all 3 Pubmed References
Human Monoclonal CD137 Primary Antibody for Func, FACS - ABIN2749216 : Chan, Voskens, Lin, Schindler, Azimzadeh, Wang, Taylor, Strome, Schulze: Epitope mapping of a chimeric CD137 mAb: a necessary step for assessing the biologic relevance of non-human primate models. in Journal of molecular recognition : JMR 2009 (PubMed) Show all 3 Pubmed References
Cetuximab-mediated NK-cell expression of CD137 on tumor-infiltrating lymphocytes is dependent on FcgammaRIIIa polymorphism. In neoadjuvant cetuximab-treated patients with head and neck cancer, upregulation of CD137 by intratumoral, cetuximab-activated NK cells correlated with FcgammaRIIIa V/F polymorphism and predicted clinical response.
In this study we systematically evaluated a series of CAR constructs targeting glypican-3 (GPC3 (show GPC3 Antibodies)), which is selectively expressed on several solid tumors. We compared GPC3 (show GPC3 Antibodies)-specific CARs that encoded CD3zeta (show CD247 Antibodies) (Gz) alone or with costimulatory domains derived from CD28 (show CD28 Antibodies) (G28z), 4-1BB (GBBz), or CD28 (show CD28 Antibodies) and 4-1BB (G28BBz).
4-1BB and 4-1BBL (show TNFSF9 Antibodies) qualify as markers for prediction of patients' course and represent a valuable screening target for patients with acute myeloid leukemia (show BCL11A Antibodies) at initial diagnosis.
the role of CD137-CRDI (cysteine rich domain I) in the binding of CD137-CD137L (show TNFSF9 Antibodies) was further investigated.
Egr2 (show EGR2 Antibodies)-driven cell surface proteins LAG-3 (show LAG3 Antibodies) and 4-1BB can identify dysfunctional tumor antigen-specific CD8 (show CD8A Antibodies)(+) TIL (show TLR1 Antibodies).
Findings indicate that CD137 antigen is a useful marker that can be used for identifying Mycobacterium tuberculosis (Mtb (show NCAPG2 Antibodies))-reactive CD4 (show CD4 Antibodies)(+) T cells (Mtb (show NCAPG2 Antibodies)-reactive CD4 (show CD4 Antibodies)(+) T cells) by flow cytometry.
Anti-4-1BB single chain variable fragments enhanced surface CD69 (show CD69 Antibodies) expression and interleukin-2 (show IL2 Antibodies) production in stimulated CCRF-CEM cells which confirmed the agonistic effect of the selected single chain variable fragments. The data from this study have provided a rationale for further experiments involving the biological functions of anti-4-1BB single chain variable fragments in future studies.
Studies suggest that adoptive T cell therapy and CD137 antigen offer much opportunity to raise the efficacy of current cancer immunotherapies.
Triple costimulation via CD80 (show CD80 Antibodies), 4-1BB, and CD83 (show CD83 Antibodies) ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2 (show IL2 Antibodies).
These studies provide the first direct evidence that ligation of tumour necrosis factor (show TNF Antibodies) superfamily members and their cognate receptors is important for the control of viral lytic replication.
CD137 signaling activates the pro-angiogenic Smad1 (show SMAD1 Antibodies)/5 pathway, induces the phosphorylation of Smad1 (show SMAD1 Antibodies)/5 and nuclear translocation of p-Smad1 (show SMAD1 Antibodies)/5, which in turn promotes the expression and translocation of NFATc1 (show NFATC1 Antibodies). Blocking CD137 signaling with inhibitory anti-CD137 antibody could inhibit this activation and attenuated agonist anti-CD137 antibody-induced angiogenesis.
Data indicate that anti-CD137 agonists can function as inhibitors of CD137L (show TNFSF9 Antibodies) signaling, resulting in the creation of tumor microenvironments unfavorable for tumor immune evasion.
These studies reveal that the costimulatory effects of TLR1 (show TLR1 Antibodies)-TLR2 signaling in CD8 (show CD8A Antibodies)(+) T cells are in part mediated by 4-1BB and are important for mounting an effective antitumor immune response.
This study discovers the 4-1BB pathway signaling enhances inflammatory response and promotes pulmonary fibrosis induced by crystalline silica.
Constitutive interaction between 4-1BB and 4-1BBL (show TNFSF9 Antibodies) on murine LPS (show TLR4 Antibodies)-activated bone marrow dendritic cells masks detection of 4-1BBL (show TNFSF9 Antibodies) by TKS (show PTK6 Antibodies)-1 but not 19H3 antibody.
results indicate that one important diabetogenic function of CD137 is to promote the expansion and accumulation of beta cell-autoreactive CD8 (show CD8A Antibodies) T cells, and in the absence of CD137 or its interaction with CD137 ligand, type 1 diabetes progression is suppressed
High CD137 expression is associated with neoplasms.
Ly6C, 4-1BB, and KLRG1 (show KLRG1 Antibodies) have roles in the activation of lamina propria lymphocytes in the small intestine in a mouse model of Crohn's disease
CD137 Regulates NFATc1 (show NFATC1 Antibodies) Expression in Mouse VSMCs through TRAF6 (show TRAF6 Antibodies)/NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) Signaling Pathway.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
tumor necrosis factor receptor superfamily, member 9 , tumor necrosis factor receptor superfamily member 9 , 4-1BB ligand receptor , CD137 antigen , T cell antigen ILA , T-cell antigen 4-1BB homolog , T-cell antigen ILA , homolog of mouse 4-1BB , induced by lymphocyte activation (ILA) , interleukin-activated receptor, homolog of mouse Ly63 , receptor protein 4-1BB , T-cell antigen 4-1BB , secreted CD137 antigen