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TP63 encodes a member of the p53 family of transcription factors. Additionally we are shipping p63 Antibodies (79) and p63 Kits (31) and many more products for this protein.
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Human p63 Protein expressed in Wheat germ - ABIN1323400
Huang, Jeong, Okamura, Sook-Kim, Zhu, Guerrero-Preston, Ratovitski: Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012
multiple ankyloblepharon-ectodermal defects-cleft lip/palate syndrome-associated p63 (show RPE65 Proteins) mutations, but not those causative of other diseases, lead to thermodynamic protein destabilization, misfolding, and aggregation
LINC01503 is increased in squamous cell carcinoma (SCC (show CYP11A1 Proteins)) cells compared with non-tumor cells. TP63 bound to the super enhancer at the LINC01503 locus activates its transcription which promotes SCC (show CYP11A1 Proteins) cell proliferation, migration, invasion, and growth of xenograft tumors.
we provide evidence that S100A7 (show S100A7 Proteins) also inhibits YAP (show YAP1 Proteins) expression and activity through p65 (show GORASP1 Proteins)/NFkappaB (show NFKB1 Proteins)-mediated repression of DeltaNp63, and S100A7 (show S100A7 Proteins) represses drug-induced apoptosis via inhibition of YAP (show YAP1 Proteins).
DeltaNp63 promotes head and neck squamous cell carcinoma tumorigenesis via regulation of hyaluronic acid metabolism. p63 (show RPE65 Proteins) expression is a negative prognostic factor of HNSCC patient survival.
cases illustrate that: there is significant familial variability, including discordant major but concordant minor anomalies in the first ever reported set of molecularly confirmed monozygotic twins with pathogenic variants in TP63.
results reveal a critical role for KMT2D in the control of epithelial enhancers and p63 (show RPE65 Proteins) target gene expression.
Loss of Nrf2 (show GABPA Proteins) inhibits deltaNp63 stem cell mobilization, a key event for reconstitution of radiation-injured lung, while promoting a myofibroblast phenotype that is central for fibrosis.
PKC-delta (show PKCd Proteins) played as a protective role in squamous cell carcinomas partly by down-regulating p63 (show RPE65 Proteins), leading to the suppression of squamous cell carcinomas cell proliferation
Immunocytochemical staining using cocktail antibody targeting p63 (show RPE65 Proteins)/CK14 (show KRT14 Proteins) was useful for the differential diagnosis of FA and DCIS in FNAC of the breast.
Authors conclude that TP63 mutations are frequent in cutaneous melanoma, support UV etiology, but their role in melanomagenesis is unclear.
p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses
they unravel essential roles of TAp63 and p53 (show TP53 Proteins) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (show NOTCH1 Proteins) signalling and caspase 3 (show CASP3 Proteins) activity.
the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (show BBC3 Proteins) transcription in response to ER stress.
Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)
DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)
rps19 (show RPS19 Proteins)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (show TP53 Proteins) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia
The results indicate that ZIP10 (show SLC39A10 Proteins) plays important roles in epidermal development via, at least in part, the ZIP10 (show SLC39A10 Proteins)-zinc-p63 (show CKAP4 Proteins) signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis.
Notch signaling maintains p63 levels and horizontal basal cell (HBC) dormancy, in contrast to its suppression of p63 expression in other tissues. Additionally, Notch1, but not Notch2, is required to maintain HBC dormancy after selective neuronal degeneration.
present study, we provided a role for IDH2 (show IDH2 Proteins) in protection against UVB-induced skin damage and a new connection between IDH2 (show IDH2 Proteins) and DeltaNp63.
Overexpression of DeltaNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with Atopic dermatitis and IL-31 (show IL31 Proteins) and IL-33 (show IL33 Proteins) are key players in the signaling pathways.
cells expressing both p63 (show CKAP4 Proteins) and p73 (show ARHGAP24 Proteins) exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.
Data suggest that this the selective targeting of genes by tumor suppressor protein (show TP53 Proteins) p63 (p63 (show CKAP4 Proteins)) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends.
p63alpha protein up-regulates heat shock protein 70 (show HSP70 Proteins) expression via E2F1 transcription factor (show E2F1 Proteins) 1 (show HNF1A Proteins), promoting Wasf3/Wave3 (show WASF3 Proteins)/MMP9 (show MMP9 Proteins) signaling and bladder cancer invasion
these results therefore highlight an unanticipated role for p53 (show TP53 Proteins) family proteins in a regulatory network that integrates essential Wnt (show WNT2 Proteins)-Tcf (show HNF4A Proteins) and nodal-Smad (show SMAD1 Proteins) inputs.
the double mutant spermatocytes apoptosed at late pachynema because of sex body deficiency; thus p53 (show TP53 Proteins) and TAp63 are dispensable for arrest caused by sex body defects. These data affirm that recombination-dependent and sex body-deficient arrests occur via genetically separable mechanisms.
TGFb3 (show TGFB3 Proteins)-induced down-regulation of p63 (show CKAP4 Proteins) in the medial edge epithelia of the palatal shelves is a pre-requisite for palatal fusion by facilitating periderm migration from, and reducing the proliferative potential of, the midline epithelial seam thereby preventing cleft palate.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (show BMP4 Proteins).
The role of p63 as a negative Wnt (show WNT2 Proteins)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.
, amplified in squamous cell carcinoma
, chronic ulcerative stomatitis protein
, keratinocyte transcription factor KET
, transformation-related protein 63
, tumor protein 63
, tumor protein p53-competing protein
, tumor protein p63 deltaN isoform delta
, tumor protein p63
, transformation related protein 63
, tumor protein 63 kDa
, tumor protein 63-like