Tumor Protein P63 Proteins (TP63)

TP63 encodes a member of the p53 family of transcription factors. Additionally we are shipping p63 Antibodies (88) and p63 Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TP63 8626 Q9H3D4
TP63 246334 Q9JJP6
TP63 22061 O88898
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Top p63 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Baculovirus infected Insect Cells Human GST tag,His tag 100 μg Log in to see 14 to 16 Days
$437.80
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,976.50
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$511.69
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Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
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Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$310.00
Details

TP63 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus)

Mouse (Murine) ,

Top referenced p63 Proteins

  1. Human p63 Protein expressed in Wheat germ - ABIN1323400 : Huang, Jeong, Okamura, Sook-Kim, Zhu, Guerrero-Preston, Ratovitski: Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012 (PubMed)

More Proteins for Tumor Protein P63 (TP63) Interaction Partners

Human Tumor Protein P63 (TP63) interaction partners

  1. Expression of TAp63, I (show RPE65 Proteins)KKbeta and XBP1s is also increased (show TP53 Proteins) in livers of obese patients with liver steatosis .

  2. p63 (show RPE65 Proteins) may act as either an oncogene (show RAB1A Proteins) or a tumor suppressor gene in different scenarios: TA isoforms of p63 (show RPE65 Proteins) gene are generally tumor-suppressive through repressing cell proliferation, survival and metastasis; DeltaN isoforms, however, may initiate tumorigenesis via promoting cell proliferation and survival. (Review)

  3. Low TP63 expression is associated with neoplasms.

  4. Studies suggest for dissecting tumor protein p63 (p63)-controlled mechanisms in normal and diseased epidermal development and for developing therapeutic options [Review].

  5. In leukoplakia, increased expression of survivin reflects on the increased expression of ki-67 (show MKI67 Proteins) and p63 (show RPE65 Proteins).

  6. Gene-gene interaction between MSX1 (show MSX1 Proteins) and TP63 may influence the risk of nonsyndromic cleft lip with or without cleft palate in Asian populations.

  7. High N-terminally truncated isoform of p63 (show RPE65 Proteins) expression is associated with squamous cell carcinogenesis.

  8. The rs35592567 polymorphism in TP63 affected the expression of TP63 by interfering with its interaction with miR (show MLXIP Proteins)-140, and could serve as an explanation for the increased risk of Gastric Cancer.

  9. The data from this study showed that p63 was a tumor suppressor mainly through regulating PTEN in chondrosarcoma cells.

  10. we first demonstrated that upregulation of P63 (show RPE65 Proteins) in the cartilage tissues of osteoarthritis (OA) patients inhibited chondrocyte autophagy thereby contributing to the malignant progression of OA.

Horse (Equine) Tumor Protein P63 (TP63) interaction partners

  1. p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses

Zebrafish Tumor Protein P63 (TP63) interaction partners

  1. they unravel essential roles of TAp63 and p53 (show TP53 Proteins) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (show NOTCH1 Proteins) signalling and caspase 3 (show CASP3 Proteins) activity.

  2. the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (show BBC3 Proteins) transcription in response to ER stress.

  3. Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)

  4. DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)

  5. rps19 (show RPS19 Proteins)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (show TP53 Proteins) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia

Mouse (Murine) Tumor Protein P63 (TP63) interaction partners

  1. Down-regulation of p63 (show CKAP4 Proteins) attenuates liver steatosis in p53 (show TP53 Proteins) knockout mice and in diet-induced obese mice, whereas the activation of p63 (show CKAP4 Proteins) induces lipid accumulation.

  2. Low TP63 expression is associated with neoplasms.

  3. The results indicate that ZIP10 (show SLC39A10 Proteins) plays important roles in epidermal development via, at least in part, the ZIP10 (show SLC39A10 Proteins)-zinc-p63 (show CKAP4 Proteins) signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis.

  4. Notch signaling maintains p63 levels and horizontal basal cell (HBC) dormancy, in contrast to its suppression of p63 expression in other tissues. Additionally, Notch1, but not Notch2, is required to maintain HBC dormancy after selective neuronal degeneration.

  5. present study, we provided a role for IDH2 (show IDH2 Proteins) in protection against UVB-induced skin damage and a new connection between IDH2 (show IDH2 Proteins) and DeltaNp63.

  6. Overexpression of DeltaNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with Atopic dermatitis and IL-31 (show IL31 Proteins) and IL-33 (show IL33 Proteins) are key players in the signaling pathways.

  7. cells expressing both p63 (show CKAP4 Proteins) and p73 (show ARHGAP24 Proteins) exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.

  8. Data suggest that this the selective targeting of genes by tumor suppressor protein (show TP53 Proteins) p63 (p63 (show CKAP4 Proteins)) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends.

  9. p63alpha protein up-regulates heat shock protein 70 (show HSP70 Proteins) expression via E2F1 transcription factor (show E2F1 Proteins) 1 (show HNF1A Proteins), promoting Wasf3/Wave3 (show WASF3 Proteins)/MMP9 (show MMP9 Proteins) signaling and bladder cancer invasion

  10. these results therefore highlight an unanticipated role for p53 (show TP53 Proteins) family proteins in a regulatory network that integrates essential Wnt (show WNT2 Proteins)-Tcf (show HNF4A Proteins) and nodal-Smad (show SMAD1 Proteins) inputs.

Xenopus laevis Tumor Protein P63 (TP63) interaction partners

  1. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  2. The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (show BMP4 Proteins).

  3. The role of p63 as a negative Wnt (show WNT2 Proteins)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.

p63 (TP63) Protein Profile

Protein Summary

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Gene names and symbols associated with Tumor Protein P63 Proteins (TP63)

  • tumor protein p63 (TP63)
  • tumor protein p63 (tp63)
  • tumor protein p63 (Tp63)
  • transformation related protein 63 (Trp63)
  • tumor protein p63 L homeolog (tp63.L)
  • AI462811 protein
  • AIS protein
  • B(p51A) protein
  • B(p51B) protein
  • DNp63 protein
  • EEC3 protein
  • id:ibd3516 protein
  • ket protein
  • LMS protein
  • NBP protein
  • np63 protein
  • OFC8 protein
  • p40 protein
  • p51 protein
  • P51/P63 protein
  • p53CP protein
  • P63 protein
  • p73H protein
  • P73l protein
  • RHS protein
  • SHFM4 protein
  • TP53CP protein
  • TP53L protein
  • Tp63 protein
  • Tp73l protein
  • tp73l-A protein
  • Trp53rp1 protein
  • trp63 protein
  • wu:fc89f04 protein
  • wu:fk85h07 protein
  • wu:fk88b02 protein
  • Xp63 protein

Protein level used designations for Tumor Protein P63 Proteins (TP63)

CUSP , amplified in squamous cell carcinoma , chronic ulcerative stomatitis protein , keratinocyte transcription factor KET , transformation-related protein 63 , tumor protein 63 , tumor protein p53-competing protein , tumor protein p63 deltaN isoform delta , tumor protein p63 , delta-Np63 , fc89f04 , transformation related protein 63 , tumor protein 63 kDa , tumor protein 63-like

GENE ID SPECIES
8626 Homo sapiens
100059752 Equus caballus
100170632 Oryzias latipes
260407 Danio rerio
703997 Macaca mulatta
615335 Bos taurus
246334 Rattus norvegicus
374269 Gallus gallus
460930 Pan troglodytes
488125 Canis lupus familiaris
100227936 Taeniopygia guttata
100386953 Callithrix jacchus
100444448 Pongo abelii
100606847 Nomascus leucogenys
22061 Mus musculus
373640 Xenopus laevis
100625258 Sus scrofa
100355881 Oryctolagus cuniculus
100732143 Cavia porcellus
101108874 Ovis aries
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