Tyrosyl-DNA Phosphodiesterase 1 Proteins (TDP1)

The protein encoded by TDP1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. Additionally we are shipping TDP1 Antibodies (103) and TDP1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TDP1 55775 Q9NUW8
TDP1 104884  
TDP1 314380 Q4G056
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Top TDP1 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 13 to 16 Days
$1,230.77
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 15 to 18 Days
$544.00
Details
Escherichia coli (E. coli) Rat Un-conjugated SDS-PAGE analysis of Rat TDP1 Protein. 100 μg Log in to see 11 to 18 Days
$525.90
Details
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse TDP1 Protein. 100 μg Log in to see 11 to 18 Days
$511.69
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$400.00
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,756.50
Details

TDP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,

Rat (Rattus) ,
,

Top referenced TDP1 Proteins

  1. Human TDP1 Protein expressed in Wheat germ - ABIN1322434 : Takahashi, Tada, Igarashi, Koyama, Date, Yokoseki, Shiga, Yoshida, Tsuji, Nishizawa, Onodera: Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends. in Nucleic acids research 2007 (PubMed)

More Proteins for Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Interaction Partners

Human Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. The role of conserved residues Y204, F259, S400 and W590 of the catalytic groove of TDP1 protein DNA cleavage activity was analyzed.

  2. We found the rs942190 GG genotype of TDP1 to be associated with relatively poor survival among small-cell lung cancer patients. Further investigation is needed to confirm the result and to determine whether this genotype may be a predictive marker for treatment efficacy of DNA topoisomerase inhibitors

  3. this study identifies the importance of TDP1 as a novel determinant of response to CNDAC across various cancer types (especially non-small cell lung cancers), and demonstrates the differential involvement of BRCA2 (show BRCA2 Proteins), PARP1 (show PARP1 Proteins), and TDP1 in the cellular responses to CNDAC, AraC, and CPT (show CHPT1 Proteins)

  4. Data indicate that the initial step of tyrosyl-DNA phosphodiesterase 1 (Tdp1) interaction with DNA includes binding of Tdp1 to the DNA ends followed by the 3'-nucleosidase reaction.

  5. Data indicate a molecular basis for DNA 3'-end processing by tyrosyl-DNA phosphodiesterase (Tdp1).

  6. Expression of human Tdp1HisnucAla and Tdp1HisgabAsn mutants results in stabilization of the covalent TDP1-DNA intermediate and induces cytotoxicity.

  7. We show that two genes, TDP1, a tyrosyl-DNA-phosphdiesterase, and TAF12 (show TAF12 Proteins), an RNA polymerase II TATA-box binding factor, cause CIN (show PDXP Proteins) when overexpressed in human cells. Using SDL screens in yeast, we identified a set of genes that when deleted specifically kill cells with high levels of Tdp1

  8. TDP1 participation in human non-homologous end joining (NHEJ) is mediated by interaction with XLF (show NHEJ1 Proteins), and that TDP1-XLF (show NHEJ1 Proteins) interactions and subsequent NHEJ events are regulated by phosphorylation of TDP1-S81.

  9. Mutations in TDP1 and APTX have been linked to Spinocerebellar ataxia with axonal neuropathy (SCAN1) and Ataxia-ocular motor apraxia 1 (AOA1), respectively, while mutations in PNKP are considered to be responsible for Microcephaly with seizures (MCSZ) and Ataxia-ocular motor apraxia 4 (AOA4).

  10. The data obtained suggest that PARP1 (show PARP1 Proteins) and TDP1 bind in an antiparallel orientation; the N-terminus of the former protein interacts with the C-terminal domain of the latter.

Mouse (Murine) Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. These findings provide evidence for TDP1 as a novel mitochondrial enzyme.

  2. The interaction with Lig3alpha is promoted by serine 81 that is located within a putative S/TQ site in the N-terminus domain of TDP1.

  3. Data indicate that TDP1 is required for neural homeostasis and reveal a widespread requisite for TDP1 function in response to acutely elevated levels of DNA topoisomerase I (Top1 (show TOP1 Proteins))-associated DNA strand breaks.

  4. This study provides a direct demonstration that Tdp1 repairs Topo I (show TOP1 Proteins) covalent lesions in vivo and suggests that spinocerebellar ataxia with axonal neuropathy (SCAN1 (show CANT1 Proteins)) arises from the recessive neomorphic mutation H493R.

  5. Tdp1(-/-) fibroblasts exhibited deficiencies in processing 3'-phosphotyrosyl single-strand breaks and 3'-phosphoglycolate double-strand breaks, but not 3 (show CNOT3 Proteins)'-phosphoglycolate single-strand breaks.

Arabidopsis thaliana Tyrosyl-DNA Phosphodiesterase 1 (TDP1) interaction partners

  1. AtTDP plays a clear role in the repair of topoisomerase I (show TOP1 Proteins)-DNA complexes.

TDP1 Protein Profile

Protein Summary

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Gene names and symbols associated with TDP1

  • tyrosyl-DNA phosphodiesterase 1 (TDP1)
  • tyrosyl-DNA Phosphodiesterase (Tdp1) (Tc00.1047053511191.10)
  • tyrosyl-DNA phosphodiesterase 1 (Tdp1)
  • tyrosyl-DNA phosphodiesterase 1 L homeolog (tdp1.L)
  • tyrosyl-DNA phosphodiesterase 1 (tdp1)
  • tyrosyl-DNA phosphodiesterase-like protein (TDP1)
  • tyrosyl-DNA phosphodiesterase 1 (PTRG_11198)
  • tyrosyl-DNA phosphodiesterase 1 (MCYG_02121)
  • tyrosyl-DNA phosphodiesterase 1 (MGYG_03035)
  • 2810481F14Rik protein
  • 4921509N21Rik protein
  • AI838772 protein
  • AW493413 protein
  • E430034L06Rik protein
  • F8M21.60 protein
  • F8M21_60 protein
  • MGC83708 protein
  • MLZ-501 protein
  • SCAN1 protein
  • TDP1 protein
  • tyrosyl-DNA phosphodiesterase 1 protein

Protein level used designations for TDP1

tyr-DNA phosphodiesterase 1 , tyrosyl-DNA Phosphodiesterase (Tdp1) , protein expressed in male leptotene and zygotene spermatocytes 501 , tyrosyl-DNA phodphodiesterase 1 , tyrosyl-DNA phosphodiesterase 1 , tyrosyl-DNA phosphodiesterase 1-like , Tyrosyl-DNA phosphodiesterase 1-like protein

GENE ID SPECIES
55775 Homo sapiens
3534433 Trypanosoma cruzi strain CL Brener
104884 Mus musculus
314380 Rattus norvegicus
423403 Gallus gallus
446983 Xenopus laevis
453096 Pan troglodytes
517053 Bos taurus
571485 Danio rerio
695338 Macaca mulatta
734106 Xenopus (Silurana) tropicalis
831369 Arabidopsis thaliana
6349511 Pyrenophora tritici-repentis Pt-1C-BFP
9229242 Arthroderma otae CBS 113480
10030819 Arthroderma gypseum CBS 118893
100388128 Callithrix jacchus
100432320 Pongo abelii
100593301 Nomascus leucogenys
100724667 Cavia porcellus
100062463 Equus caballus
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