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Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties.
Showing 10 out of 40 products:
Human Monoclonal UGCG Primary Antibody for ELISA, WB - ABIN521242
Haynes, Filippov, Filippova, Yang, Zhang, Duerksen-Hughes: DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells. in Biochimica et biophysica acta 2012
Show all 2 Pubmed References
Human Polyclonal UGCG Primary Antibody for IF (p), IHC (p) - ABIN672096
Chen, Yin, Cheng, Ding, Gao, Sun, Zhao, Wang, Bao, Xia, Gao, Wang: Effect of D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and tetrandrine on the reversion of multidrug resistance in K562/A02 cells. in Hematology (Amsterdam, Netherlands) 2011
Results suggest that the changes of DNA methylation (show HELLS Antibodies) status of the glucosylceramide synthase (GCS) promoter correlates with multidrug resistance in breast cancer.
Glucosylceramide synthase upregulation is associated with sorafenib resistance in hepatocellular carcinoma.
GCS (show GCLC Antibodies) was upregulated in colorectal carcinoma tissues compared to control tissues.
We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1 (show SGMS1 Antibodies)), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS) in the endometrium of endometriotic women.
Our data demonstrates a correlation between the expression of the GCS (show GCLC Antibodies) protein and ER-positive/HER-2 (show ERBB2 Antibodies) negative breast cancer
our work indicates that some UGCG polymorphisms are modifying factors in the severity of GD.
GCS (show GCLC Antibodies) was upregulated in PTCs and might be an independent factor affecting prognosis.
Glucosylceramide synthase mRNA were reduced by 62%.
The results thus show that ARF6 (show ARF6 Antibodies) regulates neuronal differentiation through an effect on glucosylceramide synthase and glucosylceramide levels.
DOX could modulate the expression of GCS (show GCLC Antibodies) through the Sp1 (show PSG1 Antibodies) site of GCS (show GCLC Antibodies) promoter in ERalpha (show ESR1 Antibodies)-positive breast cancer cells
we report the development of a novel, orally available glucosylceramide synthase inhibitor (Genz-682452) with pharmacological and safety profiles that have potential for treating Fabry disease.
These results suggest that neuronal glucosylceramide synthase expression modulates mediobasal hypothalamus insulin (show INS Antibodies) signaling and white adipose tissue function in fasted mice.
we measured the expression and activities of Pgp and GCS, UDP-glucose levels, cellular uptake of C12-NBD-ceramide (a fluorescent analogue of ceramide) and ceramide-induced cell death in S and R cells.
Data indicate that verexpression of glucosylceramide synthase in myotubes induces glucosylceramide but enhances insulin (show INS Antibodies) signaling.
Data indicate that mice fed D- threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), an inhibitor of glucosylceramide synthase and lactosylceramide synthase showed marked reduction in tumor volume.
The present work demonstrates that hypothalamic integration of metabolic signals requires neuronal expression of glucosylceramide synthase (GCS; UDP-glucose:ceramide glucosyltransferase).
Data indicate that mice with cerebroside sulfotransferases (Cst (show CORT Antibodies)) and UDP-glucose:ceramide glucosyltransferase (Ugcg)/Cst (show CORT Antibodies) deficiency had lower ammonium excretion.
glycosphingolipids in hepatocytes are not essential for sterol, glucose, or lipoprotein metabolism. Ugcg inhibitors exert their effect on hepatocytes either independently of GSL (show CTSA Antibodies) or mediated by other (liver) cell types.
Ugcg and Ugt8a (show UGT8 Antibodies) deficient oligodendroglial did not exhibit any phenotypic or myelin structural abnormalities; abundant and structurally intact myelin can form in their absence
Shortly after birth UgcG deficient mice showed dysfunction of cerebellum and peripheral nerves, associated with structural defects
Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in glycosphingolipid biosynthesis. The product, glucosylceramide, is the core structure of more than 300 GSLs. UGCG is widely expressed and transcription is upregulated during keratinocyte differentiation.
, UDP-glucose ceramide glucosyltransferase b
, ceramide glucosyltransferase b
, ceramide glucosyltransferase-B
, UDP-glucose:N-acylsphingosine D-glucosyltransferase
, glucosylceramide synthase
, ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21
, UDP-glucose:ceramide glycosyltransferase