anti-UDP-Glucose Ceramide Glucosyltransferase (UGCG) Antibodies

Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. Additionally we are shipping UGCG Kits (32) and UGCG Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UGCG 7357 Q16739
UGCG 22234 O88693
UGCG 83626 Q9R0E0
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Top anti-UGCG Antibodies at

Showing 10 out of 41 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-UGCG Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Spleen 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated WB Western blot analysis of UGCG expression in A375 (A), MCF7 (B), Raw264.7 (C), PC12 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
Bat Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti GCS/glucosylceramide synthase Polyclonal Antibody, Unconjugated (ABIN672096) at 1:200 followed by conjugation to the secondary antibody and DAB staining Mouse splenocytes probed with Rabbit Anti-Ceramide glucosyltransferase Polyclonal Antibody, Unconjugated . 100 μL Log in to see 3 to 7 Days
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 15 to 18 Days
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Mouse Skin Tissue. Figure. Western Blot; Sample: Recombinant UGCG, Human. 100 μg Log in to see 15 to 18 Days
Human Rabbit Un-conjugated WB 100 μg Log in to see 11 to 14 Days
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged UGCG is 0.3 ng/ml as a capture antibody. Western Blot detection against Immunogen (36.63 KDa) . 100 μg Log in to see 11 to 12 Days
Human Rabbit Un-conjugated WB UGCG antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 9 to 11 Days
Human Rabbit Un-conjugated WB Western Blot: UGCG Antibody [NBP1-62512] - Titration: 0.2-1 ug/ml, Positive Control: Human Spleen. 100 μL Log in to see 8 to 11 Days

Top referenced anti-UGCG Antibodies

  1. Human Monoclonal UGCG Primary Antibody for ELISA, WB - ABIN521242 : Haynes, Filippov, Filippova, Yang, Zhang, Duerksen-Hughes: DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells. in Biochimica et biophysica acta 2012 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal UGCG Primary Antibody for IF (p), IHC (p) - ABIN672096 : Chen, Yin, Cheng, Ding, Gao, Sun, Zhao, Wang, Bao, Xia, Gao, Wang: Effect of D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and tetrandrine on the reversion of multidrug resistance in K562/A02 cells. in Hematology (Amsterdam, Netherlands) 2011 (PubMed)

More Antibodies against UGCG Interaction Partners

Human UDP-Glucose Ceramide Glucosyltransferase (UGCG) interaction partners

  1. the GCS inhibitor lucerastat provides a viable mechanism to reduce Gb3 accumulation and lysosome volume, suitable for all Fabry patients regardless of genotype

  2. findings suggest that complex formation between SMS1 and GCS is part of a critical mechanism controlling the metabolic fate of Cer in the Golgi.

  3. Studies show a connection between UDP-glucose ceramide glucosyltransferase (UGCG) and multidrug resistance protein 1 (MDR1) overexpression and multidrug resistance development [Review].

  4. Results suggest that the changes of DNA methylation status of the glucosylceramide synthase (GCS) promoter correlates with multidrug resistance in breast cancer.

  5. Glucosylceramide synthase upregulation is associated with sorafenib resistance in hepatocellular carcinoma.

  6. GCS was upregulated in colorectal carcinoma tissues compared to control tissues.

  7. We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS) in the endometrium of endometriotic women.

  8. Our data demonstrates a correlation between the expression of the GCS protein and ER-positive/HER-2 negative breast cancer

  9. our work indicates that some UGCG polymorphisms are modifying factors in the severity of GD.

  10. GCS was upregulated in PTCs and might be an independent factor affecting prognosis.

  11. Glucosylceramide synthase mRNA were reduced by 62%.

  12. The results thus show that ARF6 regulates neuronal differentiation through an effect on glucosylceramide synthase and glucosylceramide levels.

  13. DOX could modulate the expression of GCS through the Sp1 site of GCS promoter in ERalpha-positive breast cancer cells

  14. Ceramide glycosylation catalyzed by glucosylceramide synthase is important for cancer stem cells in drug resistance and tumorigenesis.

  15. Data indicate that a high expression of glucosylceramide synthase (GCS) seemed to be an indicator of poor prognosis.

  16. The authors conclude that hepatitis C virus proteins, especially NS5A and NS5B, have positive effects on the expression of human GlcT-1.

  17. GlcT-1 is up-regulated at the mRNA and protein levels during the course of U937 differentiation, resulting in increased amounts of GlcCer.

  18. Data show that nilotinib induces apoptosis through upregulating ceramide synthase genes and downregulating SK-1 in CML cells in addition to inhibition of BCR/ABL.

  19. GCS overexpression was highly associated with ER-positive and HER2-positive breast cancer with metastasis.

  20. Data show that GCS silencing increased the levels of phosphorylated p53 and p53-responsive genes.

Mouse (Murine) UDP-Glucose Ceramide Glucosyltransferase (UGCG) interaction partners

  1. The cell division gene PCNA was significantly overexpressed in SK2(-/-) cells, suggesting a cross regulation between sphingosine kinases and Ceramide glucosyltransferase.

  2. we report the development of a novel, orally available glucosylceramide synthase inhibitor (Genz-682452) with pharmacological and safety profiles that have potential for treating Fabry disease.

  3. These results suggest that neuronal glucosylceramide synthase expression modulates mediobasal hypothalamus insulin signaling and white adipose tissue function in fasted mice.

  4. we measured the expression and activities of Pgp and GCS, UDP-glucose levels, cellular uptake of C12-NBD-ceramide (a fluorescent analogue of ceramide) and ceramide-induced cell death in S and R cells.

  5. Data indicate that verexpression of glucosylceramide synthase in myotubes induces glucosylceramide but enhances insulin signaling.

  6. Data indicate that mice fed D- threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), an inhibitor of glucosylceramide synthase and lactosylceramide synthase showed marked reduction in tumor volume.

  7. The present work demonstrates that hypothalamic integration of metabolic signals requires neuronal expression of glucosylceramide synthase (GCS; UDP-glucose:ceramide glucosyltransferase).

  8. Data indicate that mice with cerebroside sulfotransferases (Cst) and UDP-glucose:ceramide glucosyltransferase (Ugcg)/Cst deficiency had lower ammonium excretion.

  9. glycosphingolipids in hepatocytes are not essential for sterol, glucose, or lipoprotein metabolism. Ugcg inhibitors exert their effect on hepatocytes either independently of GSL or mediated by other (liver) cell types.

  10. Ugcg and Ugt8a deficient oligodendroglial did not exhibit any phenotypic or myelin structural abnormalities; abundant and structurally intact myelin can form in their absence

  11. Shortly after birth UgcG deficient mice showed dysfunction of cerebellum and peripheral nerves, associated with structural defects

UGCG Antigen Profile

Protein Summary

Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in glycosphingolipid biosynthesis. The product, glucosylceramide, is the core structure of more than 300 GSLs. UGCG is widely expressed and transcription is upregulated during keratinocyte differentiation.

Gene names and symbols associated with UGCG

  • UDP-glucose ceramide glucosyltransferase (UGCG) antibody
  • UDP-glucose ceramide glucosyltransferase S homeolog (ugcg.S) antibody
  • UDP-glucose ceramide glucosyltransferase (ugcg) antibody
  • UDP-glucose ceramide glucosyltransferase (Ugcg) antibody
  • AU043821 antibody
  • C80537 antibody
  • cb539 antibody
  • Epcs21 antibody
  • GCS antibody
  • GlcT-1 antibody
  • GLCT1 antibody
  • sb:cb539 antibody
  • ugcg antibody
  • ugcgb antibody
  • Ugcgl antibody
  • xlcgt antibody
  • zgc:112506 antibody

Protein level used designations for UGCG

ceramide glucosyltransferase , UDP-glucose ceramide glucosyltransferase b , ceramide glucosyltransferase b , ceramide glucosyltransferase-B , GlcT , GLCT-1 , UDP-glucose:N-acylsphingosine D-glucosyltransferase , glucosylceramide synthase , GCS , ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21 , UDP-glucose:ceramide glycosyltransferase

464660 Pan troglodytes
495444 Xenopus laevis
548887 Xenopus (Silurana) tropicalis
553944 Danio rerio
707875 Macaca mulatta
7357 Homo sapiens
22234 Mus musculus
83626 Rattus norvegicus
514357 Bos taurus
427335 Gallus gallus
481666 Canis lupus familiaris
100152737 Sus scrofa
100730880 Cavia porcellus
Selected quality suppliers for anti-UGCG (UGCG) Antibodies
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