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UPF1 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Additionally we are shipping UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Antibodies (64) and many more products for this protein.
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results indicate that UPF1 can dissociate miRNAs from their mRNA targets, making the miRNAs susceptible to Tudor-staphylococcal/micrococcal-like nuclease (show DCLRE1C Proteins) (TSN (show TSN Proteins))-mediated miRNA decay.
Overexpression of UPF1 inhibited cell proliferation, cell cycle progression, cell migration and invasion, and promoted cell apoptosis in gastric cancer cells. Moreover, the UPF1-mediated inhibition of gastric cancer progression was reversed by overexpression of MALAT1.
The nucleic acids processing activities of UPF1 are consistent with its function in mRNA regulation and suggest that roles in DNA replication could also be influenced by base sequence.
MARVELD1 (show MARVELD1 Proteins) substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 and Y14 (show RBM8A Proteins). MARVELD1 (show MARVELD1 Proteins) promotes the dissociation of SMG1 from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5 (show SMG5 Proteins).
UPF1 acts as an E3 ligase via its RING domain to promote MYOD protein ubiquitination and degradation and repress myogenesis.
Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR (show MLXIP Proteins)-101-3p and interacting with UPF1 in hepatocellular carcinoma, promoting tumor growth and metastasis.
Study showed that UPF1 was down-regulated due to promoter hypermethylation in hepatocellular carcinoma tissues which correlated with decreased survival.
CARM1 (show CARM1 Proteins) associates with major nonsense-mediated mRNA decay factor UPF1 and promotes its occupancy on premature terminating codon-containing transcripts in spinal muscular atrophy.
Upf1 is a RNA helicase essential for nonsense-mediated mRNA decay. Once recruited onto NMD mRNA targets, Upf1 can scan the entire transcript to irreversibly remodel the mRNP, facilitating its degradation by the NMD machinery.
Results present evidence for a critical role for Upf1 ATPase activity in nonsense-mediated decay target discrimination, with preferential ATPase-dependent release of Upf1 from non-target mRNAs as part of the underlying mechanism.
Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies .
results identify novel nonsense-mediated mRNA decay (NMD) determinants and targets and provide context for understanding the impact of UPF1 and NMD on the murine embryonic stem cell transcriptome
results suggest that the role of SMG-5 (show ZCCHC11 Proteins) is to direct protein phosphatase 2A to its SMG-2 substrate
SMG-2 interacts with SMG-3, SMG-3 interacts with SMG-4, and SMG-2 interacts indirectly with SMG-4 via shared interactions with SMG-3. SMG-2 preferentially associates with PTC (show PTCH1 Proteins)-containing mRNAs.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
ATP-dependent helicase RENT1
, UP Frameshift 1
, delta helicase
, nonsense mRNA reducing factor 1
, regulator of nonsense transcripts 1
, smg-2 homolog, nonsense mediated mRNA decay factor
, up-frameshift mutation 1 homolog
, up-frameshift suppressor 1 homolog
, yeast Upf1p homolog
, Regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog)
, LOW QUALITY PROTEIN: regulator of nonsense transcripts 1
, UPF1 regulator of nonsense transcripts homolog S homeolog