Ubiquitin Carboxyl-terminal Hydrolase L5 Proteins (UCHL5)

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains.

list all proteins Gene Name GeneID UniProt
Mouse UCHL5 UCHL5 56207 Q9WUP7
Human UCHL5 UCHL5 51377 Q9Y5K5
Rat UCHL5 UCHL5 360853  
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Top UCHL5 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$340.00
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$701.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$736.00
Details
Escherichia coli (E. coli) Cow His tag 100 μg Log in to see 15 to 18 Days
$800.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$400.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,883.83
Details
Escherichia coli (E. coli) Human His tag   50 μg Log in to see 10 to 12 Days
$260.23
Details

More Proteins for Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) Interaction Partners

Mouse (Murine) Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) interaction partners

  1. PI3K-dependent UCHL5 is required for high glucose-induced TGF-betaR1 (show CXCL11 Proteins) protein expression in mesangial cells. UCHL5 is also required for high glucose-induced TGF-betaR1 (show CXCL11 Proteins) protein deubiquitination, p21(WAF1 (show CDKN1A Proteins)) and fibronectin (show FN1 Proteins) protein expression and cell hypertrophy.

  2. ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 to activate ATP hydrolysis and enhance their own destruction

  3. this is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis

Human Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) interaction partners

  1. Our studies provide a molecular mechanism by which UCHL5 mitigates TGFbeta (show TGFB1 Proteins)-1 signaling by stabilizing Smad2 (show SMAD2 Proteins)/Smad3 (show SMAD3 Proteins). These data indicate that UCHL5 may contribute to the pathogenesis of idiopathic pulmonary fibrosis and may be a potential therapeutic target.

  2. Positive cytoplasmic UCHL5 tumor immunoexpression is linked to increased survival of patients with small (<5 cm) tumors (p = 0.001), disease stages I-II (p = 0.025), and age 66 years or older (p = 0.037). UCHL5 is thus a potential marker in gastric cancer with new prognostic relevance.

  3. our report demonstrates significant value in targeting USP14/UCHL5 with VLX1570 in drug-resistant Waldenstrom macroglobulinemia (WM) and carries a high potential for clinical translation

  4. UCHL5 is a promising novel prognostic marker in lymph-node-positive rectal cancer. Our results also advance the currently limited knowledge of biomarkers in colorectal cancer treatment.

  5. UCHL5 expression could function as a prognostic marker in pancreatic ductal adenocarcinoma, particularly at disease stages IIB to III. As UCHL5 is one of the few markers predicting increased survival, our results may be of clinical relevance.

  6. this work implicates hRpn13 (show Adrm1 Proteins) and Uch37 in cell cycle progression, providing a rationale for their function in cellular proliferation and for the apoptotic effect of the hRpn13 (show Adrm1 Proteins)-targeting molecule RA190.

  7. These results uncover a novel mechanism for E2F1 (show E2F1 Proteins) transcriptional activation through removal of its Lys (show LYZ Proteins)-63-linked ubiquitination by UCH37.

  8. Uch37 consists of two domains, a globular UCH-domain and a fibrous C-terminal tail. The C-terminal residues of Uch37 are implicated in Rpn13 binding.

  9. Data show that DEUBAD domain in RPN13 (ADRM1 (show Adrm1 Proteins)) activates ubiquitin thioesterase L5 (UCH-L5), and the related DEUBAD domain in INO80G (NFRKB (show NFRKB Proteins)) inhibits UCH-L5.

  10. Data indicate that ubiquitin thioesterase L5 UCH37 (UCHL5) comprises a catalytic UCH domain followed by the four-helix (alpha8-alpha11) C-terminal domain.

Cow (Bovine) Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) interaction partners

  1. Neither Uch37 alone nor the Uch37-Adrm1 (show Adrm1 Proteins) or Uch37-Adrm1 (show Adrm1 Proteins)-S1 complexes can hydrolyse di-ubiquitin efficiently; rather, incorporation into the 19S complex is required to enable processing of polyubiquitin (show UBB Proteins) chains.

UCHL5 Protein Profile

Protein Summary

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex\; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity).

Gene names and symbols associated with UCHL5

  • ubiquitin carboxyl-terminal hydrolase L5 (uchl5)
  • ubiquitin C-terminal hydrolase L5 (UCHL5)
  • ubiquitin C-terminal hydrolase L5 L homeolog (uchl5.L)
  • ubiquitin C-terminal hydrolase L5 (uchl5)
  • ubiquitin carboxyl-terminal esterase L5 (Uchl5)
  • ubiquitin C-terminal hydrolase L5 (Uchl5)
  • 5830413B11Rik protein
  • CGI-70 protein
  • DKFZp459M0513 protein
  • INO80R protein
  • UCH-L5 protein
  • UCH37 protein
  • wu:fj17f09 protein
  • zgc:85615 protein

Protein level used designations for UCHL5

ubiquitin carboxyl-terminal hydrolase isozyme L5 , ubiquitin carboxyl-terminal hydrolase L5 , UCH-L5 , ubiquitin C-terminal hydrolase 37 , ubiquitin C-terminal hydrolase UCH37 , ubiquitin thioesterase L5 , INO80 complex subunit R , ubiquitin carboxyl-terminal esterase L5

GENE ID SPECIES
406357 Danio rerio
424359 Gallus gallus
457596 Pan troglodytes
478958 Canis lupus familiaris
733154 Xenopus laevis
100124308 Xenopus (Silurana) tropicalis
100174635 Pongo abelii
100195039 Salmo salar
100349016 Oryctolagus cuniculus
56207 Mus musculus
51377 Homo sapiens
360853 Rattus norvegicus
282110 Bos taurus
100144472 Sus scrofa
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