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Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains.
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PI3K-dependent UCHL5 is required for high glucose-induced TGF-betaR1 (show CXCL11 Proteins) protein expression in mesangial cells. UCHL5 is also required for high glucose-induced TGF-betaR1 (show CXCL11 Proteins) protein deubiquitination, p21(WAF1 (show CDKN1A Proteins)) and fibronectin (show FN1 Proteins) protein expression and cell hypertrophy.
ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 to activate ATP hydrolysis and enhance their own destruction
this is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis
Our studies provide a molecular mechanism by which UCHL5 mitigates TGFbeta (show TGFB1 Proteins)-1 signaling by stabilizing Smad2 (show SMAD2 Proteins)/Smad3 (show SMAD3 Proteins). These data indicate that UCHL5 may contribute to the pathogenesis of idiopathic pulmonary fibrosis and may be a potential therapeutic target.
Positive cytoplasmic UCHL5 tumor immunoexpression is linked to increased survival of patients with small (<5 cm) tumors (p = 0.001), disease stages I-II (p = 0.025), and age 66 years or older (p = 0.037). UCHL5 is thus a potential marker in gastric cancer with new prognostic relevance.
our report demonstrates significant value in targeting USP14/UCHL5 with VLX1570 in drug-resistant Waldenstrom macroglobulinemia (WM) and carries a high potential for clinical translation
UCHL5 is a promising novel prognostic marker in lymph-node-positive rectal cancer. Our results also advance the currently limited knowledge of biomarkers in colorectal cancer treatment.
UCHL5 expression could function as a prognostic marker in pancreatic ductal adenocarcinoma, particularly at disease stages IIB to III. As UCHL5 is one of the few markers predicting increased survival, our results may be of clinical relevance.
this work implicates hRpn13 (show Adrm1 Proteins) and Uch37 in cell cycle progression, providing a rationale for their function in cellular proliferation and for the apoptotic effect of the hRpn13 (show Adrm1 Proteins)-targeting molecule RA190.
These results uncover a novel mechanism for E2F1 (show E2F1 Proteins) transcriptional activation through removal of its Lys (show LYZ Proteins)-63-linked ubiquitination by UCH37.
Uch37 consists of two domains, a globular UCH-domain and a fibrous C-terminal tail. The C-terminal residues of Uch37 are implicated in Rpn13 binding.
Data show that DEUBAD domain in RPN13 (ADRM1 (show Adrm1 Proteins)) activates ubiquitin thioesterase L5 (UCH-L5), and the related DEUBAD domain in INO80G (NFRKB (show NFRKB Proteins)) inhibits UCH-L5.
Data indicate that ubiquitin thioesterase L5 UCH37 (UCHL5) comprises a catalytic UCH domain followed by the four-helix (alpha8-alpha11) C-terminal domain.
Neither Uch37 alone nor the Uch37-Adrm1 (show Adrm1 Proteins) or Uch37-Adrm1 (show Adrm1 Proteins)-S1 complexes can hydrolyse di-ubiquitin efficiently; rather, incorporation into the 19S complex is required to enable processing of polyubiquitin (show UBB Proteins) chains.
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex\; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity).
ubiquitin carboxyl-terminal hydrolase isozyme L5
, ubiquitin carboxyl-terminal hydrolase L5
, ubiquitin C-terminal hydrolase 37
, ubiquitin C-terminal hydrolase UCH37
, ubiquitin thioesterase L5
, INO80 complex subunit R
, ubiquitin carboxyl-terminal esterase L5