anti-Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) Antibodies

UBR2 encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Additionally we are shipping UBR2 Kits (2) and UBR2 Proteins (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UBR2 23304 Q8IWV8
UBR2 224826 Q6WKZ8
UBR2 363188  
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Top anti-UBR2 Antibodies at antibodies-online.com

Showing 10 out of 62 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-UBR2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: MCF7 cell lysate There is BioGPS gene expression data showing that UBR2 is expressed in MCF7 Host: Rabbit Target Name: UBR2 Sample Type: Human Fetal Brain Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of UBR2 expression in HepG2 (A), mouse liver (B), rat liver (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Goat Un-conjugated ELISA, IHC   100 μg Log in to see 6 to 7 Days
$429.62
Details
Chicken Goat Un-conjugated ELISA, IHC, IHC (p) Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-UBR2 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Horse Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Mouse Goat Un-conjugated ELISA, WB Immunohistochemistry-Paraffin: UBR2 Antibody - Staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Log in to see 7 to 9 Days
$373.75
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis UBR2 using HeLa whole cell lysates ABIN6279403 at 1/100 staining Mouse pancreas tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Mouse Un-conjugated IF, RNAi, ELISA, WB Western Blot analysis of UBR2 expression in transfected 293T cell line by UBR2 monoclonal antibody (M01), clone 4G4.<br><br>Lane 1: UBR2 transfected lysate(50 KDa).<br>Lane 2: Non-transfected lysate.<br> Western blot analysis of UBR2 over-expressed 293 cell line, cotransfected with UBR2 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with UBR2 monoclonal antibody (M01), clone 4G4. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$461.00
Details
Rat Goat Un-conjugated ELISA   0.1 mg Log in to see 2 to 3 Days
$481.25
Details

Top referenced anti-UBR2 Antibodies

  1. Mouse (Murine) Polyclonal UBR2 Primary Antibody for ELISA, WB - ABIN4250454 : Zenker, Mayerle, Lerch, Tagariello, Zerres, Durie, Beier, Hülskamp, Guzman, Rehder, Beemer, Hamel, Vanlieferinghen, Gershoni-Baruch, Vieira, Dumic, Auslender, Gil-da-Silva-Lopes, Steinlicht, Rauh et al.: Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). ... in Nature genetics 2005 (PubMed)
    Show all 5 Pubmed References

More Antibodies against UBR2 Interaction Partners

Human Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) interaction partners

  1. There was a significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) observed in this research that could indicate that the combined AT-TC-CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China.

  2. The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.

  3. Study provides functional data for the mouse ubiquitin protein ligase E3 component n-recognin 2 protein.

Mouse (Murine) Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2) interaction partners

  1. Taken together, our findings indicated that p53 (show TP53 Antibodies)(-/-) mBMMSC exosomes could deliver UBR2 to target cells and promote gastric cancer growth and metastasis by regulating Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway.

  2. These data suggest that Tex19.1 and Ubr2 are required for mouse spermatocytes to accumulate sufficient Spo11 (show SPO11 Antibodies)-dependent recombination to ensure that the homology search is consistently successful, and reveal a hitherto unknown genetic pathway promoting meiotic recombination in mammals.

  3. Results suggest that UBR2 up-regulation in cachectic muscle is mediated by the p38beta (show MAPK11 Antibodies)-C/EBPbeta (show CEBPB Antibodies) signaling pathway responsible for the bulk of tumor-induced muscle proteolysis.

  4. Results suggest that the binding of Ubr2 to Tex19.1 metabolically stabilizes Tex19.1 during spermatogenesis, revealing a new function for Ubr2 outside the conventional N-end rule pathway.

  5. insufficiency in UBR2-dependent histone ubiquitination triggers a pachytene checkpoint system, providing a new insight into chromatin remodeling and gene expression regulation

  6. UBR2 ubiquitin ligase and the N-end rule pathway are required for male meiosis and spermatogenesis and for an essential aspect of female embryonic development.

  7. mouse fibroblast cells derived from Ubr2 deficient embryos display genome instability.

  8. UBR1 (show UBR1 Antibodies)-/-UBR2-/- embryos die at midgestation, with defects in neurogenesis and cardiovascular development.

UBR2 Antigen Profile

Protein Summary

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with UBR2

  • ubiquitin protein ligase E3 component n-recognin 2 (UBR2) antibody
  • ubiquitin protein ligase E3 component n-recognin 2 (ubr2) antibody
  • ubiquitin protein ligase E3 component n-recognin 2 S homeolog (ubr2.S) antibody
  • ubiquitin protein ligase E3 component n-recognin 2 (Ubr2) antibody
  • 9930021A08Rik antibody
  • AI462103 antibody
  • AW540746 antibody
  • bA49A4.1 antibody
  • C6orf133 antibody
  • dJ242G1.1 antibody
  • dJ392M17.3 antibody
  • E130209G04Rik antibody
  • mKIAA0349 antibody
  • RP3-392M17.3 antibody
  • si:ch211-239i4.2 antibody

Protein level used designations for UBR2

ubiquitin protein ligase E3 component n-recognin 2 , rp3-392m17.3 , E3 ubiquitin-protein ligase UBR2 , ubiquitin-protein ligase E3-alpha-2 , ubiquitin-protein ligase E3-alpha-II , N-recognin-2 , ubiquitin ligase E3 alpha-II

GENE ID SPECIES
100522688 Sus scrofa
100009912 Monodelphis domestica
100170193 Xenopus (Silurana) tropicalis
100542516 Meleagris gallopavo
559136 Danio rerio
734725 Xenopus laevis
421387 Gallus gallus
23304 Homo sapiens
474903 Canis lupus familiaris
527153 Bos taurus
224826 Mus musculus
363188 Rattus norvegicus
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