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Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. Additionally we are shipping USP11 Proteins (3) and many more products for this protein.
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Human Monoclonal USP11 Primary Antibody for WB - ABIN1944797
Ideguchi, Ueda, Tanaka, Yang, Tsuji, Ohno, Hagiwara, Aoki, Ishigatsubo: Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. in The Biochemical journal 2002
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show that USP11 is associated with the mitotic spindle, does not regulate SAC (show ADCY10 Antibodies) inactivation, but controls ubiquitination of RAE1 (show RAE1 Antibodies) at the mitotic spindle, hereby functionally modulating its interaction with Nuclear Mitotic Apparatus protein (NuMA (show NUMA1 Antibodies))
High USP11 expression is associated with cancer.
USP11 may contribute to the pathogenesis of pulmonary fibrosis by stabilization of TbetaRII and promotion of TGFbeta (show TGFB1 Antibodies)-1 signaling.
We demonstrated that, while depletion of XIAP (show XIAP Antibodies) attenuates cell transformation, elevated USP11 significantly promotes the tumor colony formation through stabilization of XIAP (show XIAP Antibodies).
These findings elucidate deeply and extensively the mechanism of RNF8 (show RNF8 Antibodies)/RNF168 (show RNF168 Antibodies) and USP11 to maintain the proper status of ubiquitylation gammaH2AX (show H2AFX Antibodies) to repair double strand breaks.
novel insight into cross-talk between ubiquitin and SUMO and uncover USP11 and RNF4 (show RNF4 Antibodies) as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR (show DDR1 Antibodies).
PML (show PML Antibodies) degradation mechanism through Notch (show NOTCH1 Antibodies)/Hey1 (show HEY1 Antibodies)-induced repression of USP11 involved in brain tumour pathogenesis
USP11 is a novel regulator of p53 (show TP53 Antibodies), which is required for p53 (show TP53 Antibodies) activation in response to DNA damage
Our data support a model whereby USP11 domains outside the catalytic core domain serve as protein interaction or trafficking modules rather than a direct regulatory function of the proteolytic activity.
USP-11 is not a predictor of a pCR after anthracycline-taxane-containing NST (show SULT4A1 Antibodies) for breast cancer. Low USP-11 expression was independently correlated with better survival outcomes.
USP11 augments TGFbeta (show TGFB1 Antibodies) signalling by deubiquitylating ALK5 (show TGFBR1 Antibodies).
structural and functional characterization of the USP11 deubiquitinating enzyme
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23
ubiquitin carboxyl-terminal hydrolase 11
, ubiquitin specific protease 11
, ubiquitin specific peptidase 11
, universal stress protein
, deubiquitinating enzyme 11
, ubiquitin carboxyl-terminal hydrolase, X-linked
, ubiquitin thioesterase 11
, ubiquitin thiolesterase 11
, ubiquitin-specific processing protease 11
, ubiquitin-specific-processing protease 11