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Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway.
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Human Monoclonal USP34 Primary Antibody for IF, IHC (p) - ABIN564209
Bonuccelli, Casimiro, Sotgia, Wang, Liu, Katiyar, Zhou, Dew, Capozza, Daumer, Minetti, Milliman, Alpy, Rio, Tomasetto, Mercier, Flomenberg, Frank, Pestell, Lisanti: Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature. in The American journal of pathology 2009
Show all 2 Pubmed References
Human Polyclonal USP34 Primary Antibody for ICC, IF - ABIN251342
Lui, Lacroix, Ahmed, Goldenberg, Leach, Daulat, Angers: The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling. in Molecular and cellular biology 2011
the role of USP34 on epithelial-mesenchymal (EMT (show ITK Antibodies)) induction and its effects on mammary epithelial stem cells, was investigated.
CONCLUSIONS: USP34 gene polymorphisms (rs17008097 and rs17008940) may not be associated with Polycystic ovary syndrome in the Han Chinese women.
axin (show AXIN1 Antibodies) associates with ubiquitin-specific protease 34 (USP34); results indicate USP34 controls the levels of axin (show AXIN1 Antibodies) and positively modulate Wnt (show WNT2 Antibodies) signaling by acting downstream of beta-catenin (show CTNNB1 Antibodies) stabilization through controlling the nuclear accumulation of axin (show AXIN1 Antibodies)
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).
ubiquitin carboxyl-terminal hydrolase 34
, ubiquitin specific protease 34
, ubiquitin specific peptidase 34
, ubiquitin specific peptidase 34-like
, deubiquitinating enzyme 34
, ubiquitin thioesterase 34
, ubiquitin thiolesterase 34
, ubiquitin-specific-processing protease 34
, U2af1-rs1 region 2