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USP9X is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Additionally we are shipping USP9X Proteins (2) and many more products for this protein.
Showing 10 out of 90 products:
Human Monoclonal USP9X Primary Antibody for IF, ELISA - ABIN563570
Mazumder, Choudhary, Al-Harbi, Almasan: Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells. in Cancer research 2012
Show all 6 Pubmed References
Human Polyclonal USP9X Primary Antibody for ICC, IF - ABIN4364640
Tian, Alvarez-Saavedra, Cheng, Figeys: Uncovering the proteome response of the master circadian clock to light using an AutoProteome system. in Molecular & cellular proteomics : MCP 2011
Show all 2 Pubmed References
Human Polyclonal USP9X Primary Antibody for IP, WB - ABIN253244
Pérez-Mancera, Rust, van der Weyden, Kristiansen, Li, Sarver, Silverstein, Grützmann, Aust, Rümmele, Knösel, Herd, Stemple, Kettleborough, Brosnan, Li, Morgan, Knight, Yu, Stegeman, Collier et al.: The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. ... in Nature 2012
Show all 2 Pubmed References
Dog (Canine) Monoclonal USP9X Primary Antibody for IHC, IHC (p) - ABIN4364645
Peng, Hu, Liu, He, Cui, Chen, Yang, Liu, Wei, Liu, Wang: USP9X expression correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma. in Diagnostic pathology 2014
these findings demonstrate that USP9X is a novel regulator of Von Hippel-Lindau protein (show VHLL Antibodies) stability, and USP9X may be a therapeutic target for treatment of Von Hippel-Lindau protein (show VHLL Antibodies)-related tumors
Loss of USP9X expression is associated with pancreatic cancer.
Frame shift mutation in USP9X and deletion of the 5'UTR (show UTS2R Antibodies) of the USP9X identified in two females with intellectual disability syndrome.
High USP9X expression is associated with basal-like breast cancer.
The authors find that primary human aggressive B-cell lymphoma samples exhibit high USP9X expression that correlate with XIAP (show XIAP Antibodies) overexpression.
USP9x-SMAD4 (show SMAD4 Antibodies) Interaction is associated with Breast Cancer Metastasis.
Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein)
USP9X recruited to the centrosome by NPHP5 (show IQCB1 Antibodies) protects NPHP5 (show IQCB1 Antibodies) from ubiquitination, thus favouring cilia assembly.
BAG3 (show BAG3 Antibodies) was found to positively regulate Mcl-1 (show MCL1 Antibodies) levels by binding to and inhibiting USP9X. Our data show that BAG3 (show BAG3 Antibodies) and Mcl-1 (show MCL1 Antibodies) are key mediators of resistance to chemotherapy in ovarian cancer
found that USP9X regulated the expression and stability of CLASPIN (show CLSPN Antibodies) in an S-phase-specific manner. USP9X depletion profoundly impairs the progression of DNA replication forks, causing unscheduled termination events with a frequency similar to CLASPIN (show CLSPN Antibodies) depletion, resulting in excessive endogenous DNA damage
these data suggest that TCR-mediated signals enhance Themis (show THEMIS Antibodies) stability upon T cell development and identify USP9X as a key regulator of Themis (show THEMIS Antibodies) protein turnover
In B lymphocytes, Usp9X is required for the induction of PKCbeta kinase activity after B-Cell Antigen Receptor-dependent activation.
Usp9X is a positive regulator of proximal TCR signaling in peripheral T cells and also contributes to T cell tolerance established during intrathymic development.
we identified USP9X as a potential therapeutic target in prostate cancer cells and established WP1130 as a lead compound for the development of ERG (show ERG Antibodies)-depleting drugs.
Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFbeta (show TGFB1 Antibodies)-mediated axonogenesis.
USP9X is a crucial positive regulator of the T Cell Receptor signaling pathway and is required for T-cell function through the modulation of Carma1 (show CARD11 Antibodies)-Bcl10 (show BCL10 Antibodies)-Malt1 (show MALT1 Antibodies) complex formation.
the deubiquitinase USP9X as a novel mTORC1 and -2 binding partner that negatively regulates mTOR (show FRAP1 Antibodies) activity and skeletal muscle differentiation.
loss of Usp9x enhances transformation and protects pancreatic cancer cells from anoikis
Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death.
Expressed in both germ cell and supporting cell (show PTPRJ Antibodies) lineages during mouse gonadal development in stage- and sex-dependent manners.
This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Drosophila fat facets related, X-linked
, deubiquitinating enzyme FAF-X
, fat facets in mammals
, fat facets protein related, X-linked
, fat facets protein-related, X-linked
, probable ubiquitin carboxyl-terminal hydrolase FAF-X
, ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila)
, ubiquitin thioesterase FAF-X
, ubiquitin thiolesterase FAF-X
, ubiquitin-specific processing protease FAF-X
, ubiquitin-specific protease 9, X chromosome
, ubiquitin-specific-processing protease FAF-X
, ubiquitin specific peptidase 9, X chromosome
, ubiquitin specific peptidase 9, X-linked
, ubiquitin specific protease 9, X-linked
, probable ubiquitin carboxyl-terminal hydrolase FAF-X-like
, fat facets homolog
, fats facets protein related, X
, ubiquitin carboxyl-terminal hydrolase FAM
, ubiquitin specific protease 9 SSSRF- isoform
, ubiquitin specific protease 9, X chromosome