Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) ELISA Kits

UHRF2 encodes a nuclear protein which is involved in cell-cycle regulation. Additionally we are shipping Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase Antibodies (70) and Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human UHRF2 UHRF2 115426 Q96PU4
Anti-Mouse UHRF2 UHRF2 109113 Q7TMI3
Anti-Rat UHRF2 UHRF2 309331  
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More ELISA Kits for Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase Interaction Partners

Human Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) interaction partners

  1. Here, we report the complex structure of PCNA (show PCNA ELISA Kits) and the peptide ((784)NEILQTLLDLFFPGYSK(800)) derived from UHRF2 that contains a PIP (show PIP ELISA Kits) box. Structural analysis combined with mutagenesis experiments provide the molecular basis for the recognition of UHRF2 by PCNA (show PCNA ELISA Kits) via PIP (show PIP ELISA Kits)-box.

  2. Results show that UHRF2 down-regulates a number of epithelial-mesenchymal transition markers and up-regulates the expression of transcription factors. The study also suggests that UHRF2 play a role in tumor metastasis.

  3. TIP60 (show KAT5 ELISA Kits) acted downstream of UHRF2 to regulate H3K9ac and H3K14ac expression.

  4. The overexpression of UHRF2 increased the expression of H3K9ac in L02 normal cells (P<0.01), but decreased the expression of histone H3 (show HIST3H3 ELISA Kits) lysine 9 acetylation in HepG2 cancer cells.

  5. study suggests that ZNF618 is a key protein that regulates UHRF2 function as a specific 5hmC reader in vivo.

  6. UHRF2 may contribute to the progression of colon carcinogenesis and function as a novel prognostic indicator after curative operation

  7. A hydrogen bond between the hydroxyl group of 5hmC and UHRF2-SRA (show SRA1 ELISA Kits) is critical for their preferential binding.

  8. UHRF2 is a transcriptional target of E2F (show E2F1 ELISA Kits), that it directly interacts with E2F1 (show E2F1 ELISA Kits).

  9. UHRF2, the homolog of UHRF1 (show UHRF1 ELISA Kits), interacts with N-methylpurine DNA glycosylase (MPG (show MPG ELISA Kits)) in cancer cells.

  10. Low UHRF2 mRNA expression is associated with malignant glioma.

Mouse (Murine) Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) interaction partners

  1. Uhrf2 null mice exhibit a reduction of 5-Hydroxymethylcytosine in the brain, including the cortex and hippocampus. Furthermore, the Uhrf2 null mice exhibit a partial impairment in spatial memory acquisition and retention.

  2. Uhrf2 is highly expressed in aorta and aortic vascular smooth muscle cells.

  3. UHRF2 is not able to rescue the DNA methylation (show HELLS ELISA Kits) defect in Uhrf1 (show UHRF1 ELISA Kits) null mouse embryonic stem cells.

Ubiquitin-Like with PHD and Ring Finger Domains 2, E3 Ubiquitin Protein Ligase (UHRF2) Antigen Profile

Antigen Summary

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.

Gene names and symbols associated with UHRF2

  • ubiquitin like with PHD and ring finger domains 2 (UHRF2) antibody
  • ubiquitin-like, containing PHD and RING finger domains 2 (Uhrf2) antibody
  • ubiquitin like with PHD and ring finger domains 2 (Uhrf2) antibody
  • 2310065A22Rik antibody
  • AI426270 antibody
  • AW214556 antibody
  • D130071B19Rik antibody
  • Nirf antibody
  • RNF107 antibody
  • URF2 antibody

Protein level used designations for UHRF2

E3 ubiquitin-protein ligase UHRF2 , Np95-like ring finger protein , RING finger protein 107 , np95/ICBP90-like RING finger protein , nuclear protein 97 , nuclear zinc finger protein NP97 , ubiquitin-like PHD and RING finger domain-containing protein 2 , ubiquitin-like, containing PHD and RING finger domains, 2 , ubiquitin-like-containing PHD and RING finger domains protein 2 , nuclear zinc finger protein Np97 , ubiquitin-like, containing PHD and RING finger domains 2

GENE ID SPECIES
115426 Homo sapiens
474702 Canis lupus familiaris
613759 Bos taurus
109113 Mus musculus
309331 Rattus norvegicus
100715709 Cavia porcellus
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