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UBE4A encodes a member of the U-box ubiquitin ligase family. Additionally we are shipping Ubiquitination Factor E4A Antibodies (72) and and many more products for this protein.
Ectopic overexpression of UBE4A, but not UBE3C, in cells was downregulated in vitro migration and invasion in these cells. Cumulatively, our data reveals a novel post-translational regulatory mechanism of regulating ILEI1 expression, a protein required for metastatic progression in prostate cancer cells
Identified an intestinal cDNA clone encoding ubiquitination factor E4A (UBE4A), a U-box-type ubiquitin-protein ligase (show UBE2K ELISA Kits). The prevalence of anti-UBE4A IgG in patients with CD was significantly higher than that in patients with UC or healthy controls
UBE4A was over-expressed in ovarian serous cystadenocarcinoma tissues, suggesting that the activity of ubiquitin-proteasome system is enhanced in ovarian cancer.
UBE4A is expressed in different tissues in a pattern that seems to be dependent from cell type and cell cycle and that UBE4A might have a specific role in different biochemical processes other than ubiquitination, including growth or differentiation.
In these studies, we define Ufd2 (a novel E4 polyubiquitylating enzyme) as a new autoantigen in scleroderma, and show that it regulates chromosome condensation and separation during mitosis in human cells.
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ubiquitination factor E4A (UFD2 homolog)
, ubiquitin conjugation factor E4 A
, ubiquitination factor E4A (UFD2 homolog, yeast)
, Ubiquitin conjugation factor E4 A
, ubiquitin conjugation factor E4 A-like
, ubiquitination factor E4a
, ubiquitination factor E4A
, ubiquitination factor E4A, UFD2 homolog