anti-Unc-5 Homolog C (C. Elegans) (Unc5c) Antibodies

Unc5c product belongs to the UNC-5 family of netrin receptors. Additionally we are shipping Unc5c Kits (9) and Unc5c Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Unc5c 8633 O95185
Unc5c 22253 O08747
Unc5c 362049 Q761X5
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Top anti-Unc5c Antibodies at

Showing 10 out of 105 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-UNC5C Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Jurkat cell lysate 100 μL 2 to 3 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-UNC5C Antibody Titration:  0.2-1 ug/ml  Positive Control:  COLO205 cell lysate WB Suggested Anti-UNC5C  Antibody Titration: 0.2-1 µg/mL  Positive Control: COLO205 cell lysate 100 μL 2 to 3 Days
Human Goat Un-conjugated ELISA, IF, IHC (50ug/ml) staining of islets in Mouse Pancreas. Citrate antigen retrieval. Detected by immunofluorescence. 100 μg 6 to 7 Days
Human Rabbit Un-conjugated WB 100 μg 4 to 6 Days
Mouse Goat Un-conjugated IF, ELISA Immunoflorescence (50ug/ml) staining of islets in Mouse Pancreas. Citrate antigen retrieval. Detected by immunofluorescence. Immunohistochemistry (3.8μg/ml) staining of paraffin embedded Human CerImmunohistochemistry ortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg 2 to 3 Days
Cow Rabbit Un-conjugated WB 100 μL 2 to 3 Days
Bat Goat Un-conjugated ELISA, IHC, IHC (p) 50 μg 11 to 14 Days
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated EIA, WB Formalin-fixed and paraffin-embedded human brain tissue with UNC5C Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of UNC5C Antibody (Center) in K562 cell line lysates (35ug/lane). UNC5C (arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days

Top referenced anti-Unc5c Antibodies

  1. Human Polyclonal Unc5c Primary Antibody for ICC, IF - ABIN450081 : Shin, Nagasaka, Jung, Matsubara, Kim, Carethers, Boland, Goel: Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. in Gastroenterology 2007 (PubMed)

More Antibodies against Unc5c Interaction Partners

Human Unc-5 Homolog C (C. Elegans) (Unc5c) interaction partners

  1. Promoter Hypermethylation of UNC5C Gene is associated with Colorectal Cancer.

  2. The objective of this study is to investigate the influence of UNC5C loci on the neuroimaging of strategic regions of Alzheimer's disease.

  3. we identified ENC1 and UNC5C as genes with convergent genetic, epigenetic, and transcriptomic evidence supporting a potential role in the dissociation of cognition and neuropathology in an aging population.

  4. the results suggest that UNC5C methylation may be an earlier event in the development of colorectal cancer, which was negatively correlated with protein expression.

  5. 7 of these 8 variants do not cause increased colorectal cancer risk, including UNC5C c.1882_1883delinsAA (p.A628K).

  6. Data show that overexpression of wild-type netrin receptor UNC5C (UNC5C) causes low-grade death, which is intensified by an Alzheimer Disease-linked mutation T835M, and mediated by amyloid beta precursor protein (APP).

  7. identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2

  8. we have identified novel frequent somatic mutations of UNC5C in muscle-invasive bladder cancers.

  9. T835M (rs137875858) in the UNC5C was associated with late-onset Alzheimer disease and increased cell death in HEK293 cells.

  10. The rare coding variant might not play an important role in AD risk in mainland China.

  11. UNC5C mutations are very rare in familial and sporadic colorectal carcinomas.

  12. TNM stage 1 hepatocellular carcinoma (HCC) presented UNC5C methylation, indicating that the UNC5C gene has been methylated from the early stages of HCC.

  13. knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn as well as the interaction of UNC5C with Fyn. The double knockdown of both receptors abolishes the induction of Fyn tyrosine phosphorylation by netrin-1

  14. Inherited mutations in UNC5C prevent apoptosis and increase risk of colorectal cancer.

  15. UNC5C acts as a tumour suppressor in RCC and is down-regulated in RCC. Loss of heterozygosity and DNA methylation contribute to the inactivation of UNC5C in renal cell carcinoma.

  16. UNC5C methylation was observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas.

  17. may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis

  18. Netrin binds through multiple domains to both DCC and Unc5c. in Caenorhabditis elegans indicate that both netrin binding and nonbinding domains are necessary for phenotypic rescue of an unc-5 loss of function mutation.

  19. The loss of UNC5C expression observed in human colorectal cancer is a selective advantage for tumor progression

  20. study provides evidence that most colorectal cancers have alterations in both UNC5C and DCC netrin receptors; while UNC5C expression is regulated primarily via epigenetic regulation, DCC defects are mediated through allelic deletions

Mouse (Murine) Unc-5 Homolog C (C. Elegans) (Unc5c) interaction partners

  1. Here, we report that dissociation of UNC5C and polymerized TUBB3, the highly dynamic beta-tubulin isoform in neurons, is essential for netrin-1/UNC5C-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 mutations.

  2. UNC5C expression levels increased from the 4-cell stage to the blastocyst stage in fertilized murine embryos. Repression of UNC5C in the anterior nucleus stage inhibited development to the blastocyst stage.

  3. UNC5c expression is enriched in CA3 hippocampal neurons, but UNC5c is not expressed in microglia or perpheral blood mononuclear cells.

  4. Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation.

  5. unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice. This phenotype is identical to that produced by dcc haploinsufficiency and is observed after adolescence.

  6. this study suggested that Unc5c plays a broad role in dorsal guidance of axons in the developing hindbrain.

  7. Our results provide the first evidence that genes involved in netrin signaling are necessary for proper mammalian spinal motor axon development and trochlear axon guidance.

  8. These results support an important role for UNC5C in spinal accessory motor neuron development.

  9. repression of Unc5c expression by Rhox5 may, in part, mediate the pro-survival function of Rhox5 in the testis

  10. The netrin-1 receptor UNC5c, a proapoptotic molecule that is inhibited by RHOX5, was also regulated in vivo, and is thus a candidate to be downstream of RHOX5 in a prosurvival germ-cell pathway.

Cow (Bovine) Unc-5 Homolog C (C. Elegans) (Unc5c) interaction partners

  1. Cows with higher conception rates carried the A+169G polymorphism in the 3' untranslated region of UNC5C, which transcripts were expressed at higher levels than those carrying the G polymorphism, which might cause poor preimplantation embryo development.

Unc5c Antigen Profile

Protein Summary

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin\; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.

Gene names and symbols associated with Unc5c

  • unc-5 netrin receptor C (UNC5C) antibody
  • unc-5 netrin receptor C (Unc5c) antibody
  • unc-5 netrin receptor C (unc5c) antibody
  • 6030473H24 antibody
  • AI047720 antibody
  • B130051O18Rik antibody
  • rcm antibody
  • UNC5C antibody
  • Unc5h3 antibody
  • wu:fb03d07 antibody

Protein level used designations for Unc5c

unc-5 homolog C (C. elegans) , netrin receptor UNC5C-like , netrin receptor UNC5C , protein unc-5 homolog 3 , protein unc-5 homolog C , unc-5 homolog 3 , unc5 (C.elegans homolog) c , UNC-5 homolog 3 , rostral cerebellar malformation protein , unc5 homolog 3 , fb03d07 , UNC5-like protein 3 , cUNC-5H3

471254 Pan troglodytes
100599418 Nomascus leucogenys
705591 Macaca mulatta
100016333 Monodelphis domestica
100065541 Equus caballus
100351024 Oryctolagus cuniculus
100397357 Callithrix jacchus
100443113 Pongo abelii
8633 Homo sapiens
478485 Canis lupus familiaris
22253 Mus musculus
557316 Danio rerio
395101 Gallus gallus
533256 Bos taurus
362049 Rattus norvegicus
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