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UBTF encodes a member of the HMG-box DNA-binding protein family. Additionally we are shipping Upstream Binding Transcription Factor, RNA Polymerase I Kits (4) and Upstream Binding Transcription Factor, RNA Polymerase I Proteins (4) and many more products for this protein.
Showing 10 out of 96 products:
Human Monoclonal UBTF Primary Antibody for IF, IHC (p) - ABIN563329
Østrup, Petrovicova, Strejcek, Morovic, Lucas-Hahn, Lemme, Petersen, Niemann, Laurincik, Maddox-Hyttel: Nuclear and nucleolar reprogramming during the first cell cycle in bovine nuclear transfer embryos. in Cloning and stem cells 2009
Show all 4 Pubmed References
Human Polyclonal UBTF Primary Antibody for ICC, IF - ABIN4364030
Sobol, Yildirim, Philimonenko, Marášek, Castaño, Hozák: UBF complexes with phosphatidylinositol 4,5-bisphosphate in nucleolar organizer regions regardless of ongoing RNA polymerase I activity. in Nucleus (Austin, Tex.) 2014
TP53INP2 (show TP53INP2 Antibodies) promotes ribosome biogenesis through facilitating rRNA synthesis at the nucleolus
Study demonstrated that HMG (show SSRP1 Antibodies) box 1, the linker region between the HMG (show SSRP1 Antibodies) boxes and C-terminal acidic region (AR), and the AR cooperatively regulate the nucleolar localization of UBF.
In seven unrelated affected individuals, all suffering from developmental regression starting at 2.5-7 years, the authors identified a heterozygous variant, c.628G>A in UBTF, encoding p.Glu210Lys in UBF, which occurred de novo in all cases.
RINT-1 (show RINT1 Antibodies) interacts with MSP58 (show MCRS1 Antibodies) and UBF within nucleoli and plays a role in ribosomal gene transcription.
This study provides some compelling evidences in support of HBx-elicited and c-Myc (show MYC Antibodies)-mediated increase in UBF levels that abets oncogenic onslaught in hepatic cells by increasing rDNA transcription and ribosome biogenesis.
These results suggest that UBF can inhibit gene expression from viral DNA prior to its replication.
we have uncovered a novel role for UBTF1 and UBTF2 in maintaining genome stability through coordinating the expression of highly transcribed Pol I (UBTF1 activity) and Pol II genes (UBTF2 activity).
p14ARF (show CDKN2A Antibodies) fails to prevent E7-mediated UBF1 phosphorylation, but could facilitate nucleolar pRb (show RB1 Antibodies) inactivation by targeting E7 to the nucleolus.
PIP2 depletion reduces Pol I transcription.
UBF is expressed widely by human multiple fetal tissue,s and the expression level is very high in HL-60 cells.
UBF and Nopp140 (show NOLC1 Antibodies) dynamic redistribution between the two-cell and blastocyst stages (time of implantation) is correlated with morphological and structural modifications that occur in embryonic nucleolar compartments.
inhibition of UBF function is a major factor in the cytotoxicity of cisplatin; its depletion selectively induces p53 (show TP53 Antibodies)-independent apoptotic death in transformed cells
Loss of UBF also unexpectedly induced the formation in cells of a large sub-nuclear structure resembling the nucleolar precursor body (NPB (show NPB Antibodies)) of oocytes and early embryos.
UBF1 mutation (K352A, K352Q, and K352R) decreased rDNA transcriptional activity.
augmented ribosome biogenesis occurs in UBF-dependent manner during increased protein synthesis induced by high glucose in glomerular epithelial cells that correlates with UBF activation and renal hypertrophy in rodents with type 1 and type 2 diabetes.
increased UBF levels correlate with elevated pressure load and increased cardiac growth rates
mTOR (show FRAP1 Antibodies) plays a critical role in the regulation of ribosome biogenesis via a mechanism that requires S6K1 (show RPS6KB1 Antibodies) activation and phosphorylation of UBF.
effects of PES1 (show PES1 Antibodies) and UBF1 expression on the growth and differentiation of cell lines derived from 32D cells, an interleukin-3 (IL-3 (show IL-3 Antibodies))-dependent murine myeloid cell line
Phosphatidylinositol 3-kinase subunit directly phosphorylates and activates UBF1, an exclusively nucleolar protein (show MCRS1 Antibodies).
This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11.
upstream binding transcription factor, RNA polymerase I
, nucleolar transcription factor 1-like
, 90-kDa nucleolus organizer region autoantigen
, autoantigen NOR-90
, nucleolar transcription factor 1
, transcription factor UBF
, upstream-binding factor 1