anti-Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) Antibodies

UBTF encodes a member of the HMG-box DNA-binding protein family. Additionally we are shipping Upstream Binding Transcription Factor, RNA Polymerase I Proteins (4) and Upstream Binding Transcription Factor, RNA Polymerase I Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
UBTF 7343 P17480
UBTF 21429  
UBTF 25574 P25977
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Top anti-Upstream Binding Transcription Factor, RNA Polymerase I Antibodies at antibodies-online.com

Showing 10 out of 97 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-UBTF Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:2500  Positive Control:  Hela cell lysate UBTF is supported by BioGPS gene expression data to be expressed in HeLa 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  Ubtf  Sample Type:  Rat Spleen lysates  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, IF, IHC, WB Immunofluorescence of monoclonal antibody to UBTF on HepG2 cell (antibody concentration 10 µg/mL). UBTF monoclonal antibody (M03), clone 1A2 Western Blot analysis of UBTF expression in HepG2. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Mouse Un-conjugated IF, IHC, WB Immunofluorescence of monoclonal antibody to UBTF on HepG2 cell (antibody concentration 10 µg/mL). UBTF monoclonal antibody (M04), clone 2D8 Western Blot analysis of UBTF expression in HepG2. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Mouse Un-conjugated ELISA, IF, IHC, WB Immunofluorescence of monoclonal antibody to UBTF on HeLa cell (antibody concentration 10 µg/mL). UBTF monoclonal antibody (M01), clone 6B6 Western Blot analysis of UBTF expression in HeLa NE. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Mouse Un-conjugated ELISA, IF, WB Immunofluorescence of monoclonal antibody to UBTF on HepG2 cell (antibody concentration 10 µg/mL). UBTF monoclonal antibody (M02), clone 6C6 Western Blot analysis of UBTF expression in HepG2. 100 μg Log in to see 8 to 11 Days
$527.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: UBTF Antibody  - Analysis in human cell line MOLT-4. Western Blot: UBTF Antibody  - Analysis in mouse cerebral cortex tissue. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HeLa/Jurkat cells, using UBF1 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using UBF1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6274181 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts from HeLa cells using UBF1 antibody.The lane on the left is treated with the antigen-specific peptide. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6269900 at 1/100 staining mouse liver tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6269900 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$450.00
Details

Top referenced anti-Upstream Binding Transcription Factor, RNA Polymerase I Antibodies

  1. Human Monoclonal UBTF Primary Antibody for IF, IHC (p) - ABIN563329 : Østrup, Petrovicova, Strejcek, Morovic, Lucas-Hahn, Lemme, Petersen, Niemann, Laurincik, Maddox-Hyttel: Nuclear and nucleolar reprogramming during the first cell cycle in bovine nuclear transfer embryos. in Cloning and stem cells 2009 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal UBTF Primary Antibody for ICC, IF - ABIN4364030 : Sobol, Yildirim, Philimonenko, Marášek, Castaño, Hozák: UBF complexes with phosphatidylinositol 4,5-bisphosphate in nucleolar organizer regions regardless of ongoing RNA polymerase I activity. in Nucleus (Austin, Tex.) 2014 (PubMed)

More Antibodies against Upstream Binding Transcription Factor, RNA Polymerase I Interaction Partners

Human Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) interaction partners

  1. Data underscore the importance of including UBTF E210K in the differential diagnosis of neuroregression and suggest that mainly gain-of-function mechanisms contribute to the pathogenesis of the UBTF E210K neuroregression syndrome.

  2. TP53INP2 promotes ribosome biogenesis through facilitating rRNA synthesis at the nucleolus

  3. Study demonstrated that HMG box 1, the linker region between the HMG boxes and C-terminal acidic region (AR), and the AR cooperatively regulate the nucleolar localization of UBF.

  4. In seven unrelated affected individuals, all suffering from developmental regression starting at 2.5-7 years, the authors identified a heterozygous variant, c.628G>A in UBTF, encoding p.Glu210Lys in UBF, which occurred de novo in all cases.

  5. RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription.

  6. This study provides some compelling evidences in support of HBx-elicited and c-Myc-mediated increase in UBF levels that abets oncogenic onslaught in hepatic cells by increasing rDNA transcription and ribosome biogenesis.

  7. These results suggest that UBF can inhibit gene expression from viral DNA prior to its replication.

  8. we have uncovered a novel role for UBTF1 and UBTF2 in maintaining genome stability through coordinating the expression of highly transcribed Pol I (UBTF1 activity) and Pol II genes (UBTF2 activity).

  9. p14ARF fails to prevent E7-mediated UBF1 phosphorylation, but could facilitate nucleolar pRb inactivation by targeting E7 to the nucleolus.

  10. PIP2 depletion reduces Pol I transcription.

  11. UBF is expressed widely by human multiple fetal tissue,s and the expression level is very high in HL-60 cells.

  12. Downregulation of RUNX2 expression reduces the localization of HDAC1 to the nucleolar periphery and also decreases the association between HDAC1 and UBF.

  13. hALP binds the upstream binding factor (UBF) in vivo and in vitro

  14. depletion of upstream binding factor (UBF; an rRNA transcription factor) decreased the chromatin binding affinity of B23, which in turn led to an increase in histone density at the r-chromatin

  15. The three-dimensional solution structure of the first high mobility group (HMG) box domain in upstream binding factor has been determined by multidimensional NMR.

  16. we have identified an interaction between UBF and TAF1, a factor involved in the transcription of cell cycle and growth regulatory genes. Coimmunoprecipitation and protein-protein interaction assays confirmed that TAF1 binds to UBF.

  17. The DNA binding affinity of UBF's fifth box domain (HMG box 5) is found to be much weaker than that of the first HMG box domain (HMG box 1).

  18. Data show that both UBF1 and UBF2 activate RNA polymerase II-regulated, beta-catenin-responsive promoters.

  19. Proto-Oncogene Proteins c-myc activated transcription from the UBF promoter

  20. results suggest that extensive binding of UBF is responsible for formation and maintenance of the secondary constriction at active NORs, and that UBF mediates recruitment of the pol I machinery to nucleoli independently of promoter elements

Mouse (Murine) Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) interaction partners

  1. UBF and Nopp140 dynamic redistribution between the two-cell and blastocyst stages (time of implantation) is correlated with morphological and structural modifications that occur in embryonic nucleolar compartments.

  2. inhibition of UBF function is a major factor in the cytotoxicity of cisplatin; its depletion selectively induces p53-independent apoptotic death in transformed cells

  3. Loss of UBF also unexpectedly induced the formation in cells of a large sub-nuclear structure resembling the nucleolar precursor body (NPB) of oocytes and early embryos.

  4. we have uncovered a novel role for UBTF1 and UBTF2 in maintaining genome stability through coordinating the expression of highly transcribed Pol I (UBTF1 activity) and Pol II genes (UBTF2 activity).

  5. Inhibition of the POL1 pathway delays and suppresses the development of experimental autoimmune encephalomyelitis and ameliorates the disease in mice with persistent clinical signs.

  6. UBF1 mutation (K352A, K352Q, and K352R) decreased rDNA transcriptional activity.

  7. augmented ribosome biogenesis occurs in UBF-dependent manner during increased protein synthesis induced by high glucose in glomerular epithelial cells that correlates with UBF activation and renal hypertrophy in rodents with type 1 and type 2 diabetes.

  8. increased UBF levels correlate with elevated pressure load and increased cardiac growth rates

  9. mTOR plays a critical role in the regulation of ribosome biogenesis via a mechanism that requires S6K1 activation and phosphorylation of UBF.

  10. effects of PES1 and UBF1 expression on the growth and differentiation of cell lines derived from 32D cells, an interleukin-3 (IL-3)-dependent murine myeloid cell line

  11. Phosphatidylinositol 3-kinase subunit directly phosphorylates and activates UBF1, an exclusively nucleolar protein.

  12. Proto-Oncogene Proteins c-myc activated transcription from the UBF promoter

  13. IGF-IR signaling can increase the activity of UBF1 and transcription from the rDNA promoter

  14. Myeloid cell IGF-1 receptor-mediated regulation of UBF-1 levels involves IRS-1 and ERK pathways.

Upstream Binding Transcription Factor, RNA Polymerase I (UBTF) Antigen Profile

Protein Summary

This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11.

Gene names and symbols associated with UBTF

  • upstream binding transcription factor, RNA polymerase I (ubtf) antibody
  • upstream binding transcription factor, RNA polymerase I (UBTF) antibody
  • upstream binding transcription factor, RNA polymerase I (Ubtf) antibody
  • A930005G04Rik antibody
  • NOR-90 antibody
  • si:dz180g5.3 antibody
  • Tcfubf antibody
  • ubf antibody
  • UBF-1 antibody
  • UBF1 antibody
  • UBTF antibody
  • wu:fj38c10 antibody
  • xUBF antibody

Protein level used designations for UBTF

upstream binding transcription factor, RNA polymerase I , nucleolar transcription factor 1-like , 90-kDa nucleolus organizer region autoantigen , autoantigen NOR-90 , nucleolar transcription factor 1 , UBF-1 , transcription factor UBF , upstream-binding factor 1

GENE ID SPECIES
368509 Danio rerio
454726 Pan troglodytes
497012 Bos taurus
100019759 Monodelphis domestica
100064724 Equus caballus
100135747 Xenopus (Silurana) tropicalis
100454637 Pongo abelii
100483006 Ailuropoda melanoleuca
100511403 Sus scrofa
100558152 Anolis carolinensis
7343 Homo sapiens
21429 Mus musculus
25574 Rattus norvegicus
480503 Canis lupus familiaris
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