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ERG encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors.
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despite of their well-known adverse role in prognosis of AML (show RUNX1 ELISA Kits), neither BAALC (show BAALC ELISA Kits) nor ERG expression levels at diagnosis had effect on survival of AML (show RUNX1 ELISA Kits) patients who underwent allo-HSCT.
ERG expression is lo (show TGFB1 ELISA Kits)st in liver endothelial cells (show GARS ELISA Kits) from cirr (show SMAD3 ELISA Kits)hotic patients with fibrosis related to alcoholic liver disease or primary biliary cirrhosis and inversely correlates with increas (show SMAD3 ELISA Kits)ed markers of endothelial-to-mesenchymal transition.
ERG expression is of limited prognostic value in acute myeloid leukemia (show BCL11A ELISA Kits).
Our findings indicate that TGF-beta (show TGFB1 ELISA Kits) signaling is a major determinant of EMT (show ITK ELISA Kits) in T/E overexpressing LNCaP cells.
Findings reveal that PCa-associated ERG can interact and co-occupy with BRD4 in the genome, and suggest this druggable interaction is critical for ERG-mediated cell invasion and PCa progression.
this work provides novel insights in the regulation of ERG protein stability in prostate cancer
Study reveals that miR-200b/a/429 is an ERG target gene, which implicates an important role in TMPRSS2/ERG-dependent PCa development.
ERG and SOX9 (show SOX9 ELISA Kits) are potential biomarkers for prediction of response to docetaxel treatment in metastatic castration-resistant prostate cancer patients.
A potential novel function of TMPRSS2 (show TMPRSS2 ELISA Kits)-ERG as a major regulator of IGF1R (show IGF1R ELISA Kits) gene expression.
Study shows that T2E fusion transcripts are associated with higher levels of AMACR (show AMACR ELISA Kits) mRNA in patients with atypical small acinar proliferation (ASAP (show MAP9 ELISA Kits)) which represents an indicator of risk for prostate cancer in patients with ASAP (show MAP9 ELISA Kits).
KLF2 (show KLF2 ELISA Kits) and ERG associate in a physical complex and the two proteins synergistically activate transcription of Flk1 (show KDR ELISA Kits).
fli1 (show FLI1 ELISA Kits), and etsrp, demonstrated that erg and fli1 (show FLI1 ELISA Kits) act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (show CDH5 ELISA Kits)
A combination of gain-of-function and loss-of-function studies suggested a redundant yet specific role for erg in both angioblast specification/proliferation and early angiogenesis, and a synergistic interaction with the critical ETS (show ETS1 ELISA Kits) factor etsrp.
ERG balances TGFbeta (show TGFB1 ELISA Kits) signalling through the SMAD1 (show SMAD1 ELISA Kits) and SMAD3 (show SMAD3 ELISA Kits) pathways, protecting the endothelium from endothelial-to-mesenchymal transition and consequent liver fibrosis in mice via a SMAD3 (show SMAD3 ELISA Kits)-dependent mechanism.
Reduced Erg dosage impairs survival of hematopoietic stem and progenitor cells.
loss of ERG and FLI1 (show FLI1 ELISA Kits) might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.
Combined, these data suggest a possible pathway linking GDF5 (show GDF5 ELISA Kits), ERG and downstream factors in the processes of chondrocyte differentiation during articular joint formation.
Our study reveals that ERG has essential and cell autonomous roles in endothelial cell development and blood vessel maintenance.
We show that the gene expression signature specifically attributable to trisomy of Erg in the murine model is strongly correlated with gene expression changes in human Down syndrome hematopoietic cells.
Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.
ERG plays a critical role in coordinating the balance between self-renewal and differentiation of HSCs.
ERG activates the transcriptional program regulated by YAP1 (show YAP1 ELISA Kits) of the Hippo signaling pathway and found that prostate-specific activation of either ERG or YAP1 (show YAP1 ELISA Kits) in mice induces similar transcriptional changes and results in age-related prostate tumors.
ERG and APLNR (show APLNR ELISA Kits) are essential for endothelial homeostasis in venules in the lung and that perturbation in ERG-APLNR (show APLNR ELISA Kits) signaling is crucial for the development of pulmonary veno-occlusive disease.
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
, transcriptional regulator ERG
, transcriptional regulator ERG (transforming protein ERG)
, v-ets avian erythroblastosis virus E26 oncogene related
, v-ets erythroblastosis virus E26 oncogene homolog
, v-ets erythroblastosis virus E26 oncogene like
, avian erythroblastosis virus E-26 (v-ets) oncogene related
, vascular ETS factor
, erg gene (erg_E)
, v-ets erythroblastosis virus E26 oncogene homolog (avian)
, transcriptional regulator Erg