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ETS1 encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes.
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Results indicated that miR (show MLXIP Proteins)-193a-3p suppressed gastric growth and motility, at least partly, by directly targeting cyclin D1 (CCND1 (show CCND1 Proteins)) and ETS proto-oncogene (show RAB1A Proteins) 1 (ETS1) expression.
Data indicate that in glioblastoma, ETS proto-oncogene (show RAB1A Proteins) 1 (ETS-1)-expression is not dependent on hypoxia, but correlates with tumor vascularization.
DOT1L (show DOT1L Proteins) cooperates with transcription factor ETS (show ETV7 Proteins)-1 to stimulate the expression of VEGFR2 (show KDR Proteins), thereby activating ERK1/2 and AKT (show AKT1 Proteins) signaling pathways and promoting angiogenesis.
ETS-1 plays oncogenic roles through inducing cell migration and invasion in human bladder cancer
endothelial master transcription factor ETS1 promotes global RNAPII pause release, and that this process is governed by VEGF (show VEGFA Proteins)
Data show that SOX9 (show SOX9 Proteins) regulates CEACAM1 (show CEACAM1 Proteins) primarily via Sp1 (show PSG1 Proteins) and ETS1.
The present study thus demonstrates that phosphorylation of ETS-1 is a critical event in the DNA polymerase iota (show POLI Proteins)-induced invasion and metastasis of esophageal squamous cell carcinoma (
DDC (show DDC Proteins) up-regulated MMP-1 (show MMP1 Proteins) in LX-2 cells through the Akt (show AKT1 Proteins) and ERK (show EPHB2 Proteins)/miR (show MLXIP Proteins)-222/ETS-1 pathways.
ETS-1 is a molecular target of miR (show MLXIP Proteins)-144-3p, and silencing ETS-1 expression inhibited FaDu and Hep2 cell invasion and migration as well as reduced Hep2 xenograft tumor volume.
High ETS1 expression is associated with obesity.
results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center
Dynamically and epigenetically coordinated GATA2 (show GATA2 Proteins)/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation.
data reveal ETS1 as a critical regulator of ILC2 expansion and cytokine production and implicate ETS1 in the regulation of Id2 at the inception of ILC2 development.
Ets1 predominantly binds distal nucleosome-occupied regions in double negative thymocytes and nucleosome-depleted regions in double positive thymocytes. importantly, Ets1 induces chromatin remodeling by displacing H3K4me1-marked nucleosomes.
reduced lung levels of PPARgamma (show PPARG Proteins) and increased levels of microRNA-27a (miR (show MLXIP Proteins)-27a), v-ets avian erythroblastosis virus E26 oncogene (show RAB1A Proteins) homolog 1 (ETS1), endothelin-1 (ET-1 (show EDN1 Proteins)), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 (show PECAM1 Proteins) and E selectin (show SELE Proteins)).
the affinities of two sequence-divergent ETS homologs, PU.1 and Ets-1, to DNA sites harboring a hemi- and fully methylated CpG dinucleotide, were measured.
data support a general model in which Ets-1 interacts with nonspecific DNA via dynamic electrostatic interactions, whereas hydrogen bonding drives the formation of well-ordered complexes with specific DNA
Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 (show PDX1 Proteins) expression in type 2 diabetes.
Akt2 (show AKT2 Proteins) upregulates dendritic cell migration at least in part by ETS1-dependent stimulation of IP3R2 (show ITPR2 Proteins) transcription.
The activity of Gata4 (show GATA4 Proteins) cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS sites.
Ets-1 up-regulation is involved in the development of retinal neovascularization.
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1
, ets protein
, protein C-ets-1
, v-ets avian erythroblastosis virus E2 oncogene homolog 1
, TNFAIP3 interacting protein 1
, c-ets-1 oncogene
, p54 transcription factor
, transforming protein p54/c-ets-1
, transforming protein p68/c-ets-1
, virion-associated nuclear-shuttling protein
, Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1)
, v-ets erythroblastosis virus E26 oncogene homolog 1
, v-ets erythroblastosis virus E26 oncogene-like protein 1
, Ets protein
, v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
, C-ets-1 protein (p54)
, avian erythroblastosis virus E26 oncogene 1
, tumor progression locus 1
, protein c-ets-1-B