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SRC is highly similar to the v-src gene of Rous sarcoma virus. Additionally we are shipping and many more products for this protein.
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c-Src/MAPK (show MAPK1 Antibodies)/NF-kB signaling pathway may contribute to the pathogenesis of pre-eclampsia
Data indicate the role of tyrosine kinase (show TXK Antibodies) c-Src (Src) in rescuing Taz (transcriptional coactivator with PDZ-binding motif (show WWTR1 Antibodies)) from E3 ligase SCF (show KITLG Antibodies)(beta-TrCP (show BTRC Antibodies))-mediated degradation.
Data suggest that response of bronchial epithelial cells to environmental carcinogen benzo[a]pyrene includes activation of AhR/Src/ERK signaling, CYP1A1 induction, and formation of stable DNA adducts. (AhR = aryl hydrocarbon receptor; Src = Src proto-oncogene kinase; ERK = extracellular signal-regulated kinases; CYP1A1 = cytochrome P450 family 1 subfamily A member 1)
It is unclear if we may have seen greater clinical activity if we were able to fully inhibit Src in this study, but given the requirement that enrolling patients have documented disease progression on cetuximab, acquired resistant KRAS-mutant clones may have been present, limiting future strategies to reverse EGFR (show EGFR Antibodies) resistance
this study shows that simultaneous deactivation of FAK (show PTK2 Antibodies) and Src improves the pathology of hypertrophic scar
mutations in the germline and somatic DNA of the TEK (show TEK Antibodies) gene were identified and analyze the expression level of Src and phospho-Src (p-Src) in tumor and healthy tissues from patients with facial cutaneo-mucosal venous malformations.
SOCS1 (show SOCS1 Antibodies) antagonizes epithelial-mesenchymal transition by suppressing Src activity, leading to thioredoxin (show TXN Antibodies) expression and down-regulation of ROS (show ROS1 Antibodies) levels in colon cancer cells
These findings suggest that the integrin beta4-FAK (show PTK2 Antibodies)/Src signaling axis may play a crucial role in clonorchiasis-associated cholangiocarcinoma metastasis during tumor progression.
Estrogen receptor (show ESR1 Antibodies)-Src signaling plays an important role in ER (+) breast cancer, which shows a high potential for bone metastasis.
thrombin (show F2 Antibodies) binding to PAR-1 (show MARK2 Antibodies) receptor activated Gi-protein/c (show PROC Antibodies)-Src/Pyk2 (show PTK2B Antibodies)/EGFR (show EGFR Antibodies)/PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/p42/p44 (show PSMC6 Antibodies) MAPK (show MAPK3 Antibodies) cascade, which in turn elicited AP-1 (show FOSB Antibodies) activation and ultimately evoked MMP-9 (show MMP9 Antibodies) expression and cell migration in SK-N-SH cells.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
, proto-oncogene tyrosine-protein kinase Src
, protooncogene SRC, Rous sarcoma
, tyrosine kinase pp60c-src
, tyrosine-protein kinase SRC-1