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SRC is highly similar to the v-src gene of Rous sarcoma virus. Additionally we are shipping and many more products for this protein.
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Src kinase (show CSK Antibodies) activation by nitric oxide promotes resistance to anoikis in tumor cell lines.
Src and Aurora-A (show AURKA Antibodies) interact upon Golgi ribbon fragmentation; Src phosphorylates Aurora-A (show AURKA Antibodies) at tyrosine 148 and this specific phosphorylation is required for Aurora-A (show AURKA Antibodies) localization at the centrosomes.
Study demonstrated that c-Src contributed to hypoxic microenvironment-rendered paclitaxel resistance in human epithelial ovarian cancer cells by G2/M phase arrest deterioration, and through c-Src suppression, FV-429 was capable of reversing the resistance by blocking c-Src/Stat3 (show STAT3 Antibodies)/HIF-1alpha (show HIF1A Antibodies) pathway.
Data demonstrated that the Src/Fn14 (show TNFRSF12A Antibodies)/NF-kappaB (show NFKB1 Antibodies) axis plays a critical role in NSCLC metastasis.
Results suggest that Src promotes EGF (show EGF Antibodies)-stimulated EMT (show ITK Antibodies) and migration by upregulation of ZEB1 (show ZEB1 Antibodies) and ZEB2 (show ZEB2 Antibodies) through AKT (show AKT1 Antibodies) signaling pathway in gastric cancer cells.
Combined targeting of AKT (show AKT1 Antibodies) and SRC resulted in a synergistic efficacy against human pancreatic cancer growth and metastasis.
important roles for c-Src tyrosine kinase (show CSK Antibodies) in phosphorylation and activation of SLC11A1 (show SLC11A1 Antibodies) in macrophages
Our data suggest that targeting Src signaling may be an effective approach to the treatment of ALK-non-small cell lung cancer (NSCLC) with acquired resistance to ALK inhibitors.
Src kinase (show CSK Antibodies) in chemo-naive human primary osteosarcoma cells is differentially activated.
This study demonstrates that simultaneous inhibition of c-Met and Src signaling in MD-MSCs triggers apoptosis and reveals vulnerable pathways that could be exploited to develop NF2 (show NF2 Antibodies) therapies.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
, proto-oncogene tyrosine-protein kinase Src
, protooncogene SRC, Rous sarcoma
, tyrosine kinase pp60c-src
, tyrosine-protein kinase SRC-1