Vaccinia Related Kinase 1 Proteins (VRK1)

VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Additionally we are shipping Vaccinia Related Kinase 1 Antibodies (80) and Vaccinia Related Kinase 1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
VRK1 7443 Q99986
Mouse VRK1 VRK1 22367 Q80X41
Rat VRK1 VRK1 362779  
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Top Vaccinia Related Kinase 1 Proteins at

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Baculovirus infected Insect Cells Human Un-conjugated 50 μg Log in to see 14 to 16 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see Available
Insect Cells Human His-GST 100 μg Log in to see 11 to 12 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
Escherichia coli (E. coli) Human GST tag 5 μg Log in to see 11 to 12 Days
Baculovirus Human GST-His-Tag Recombinant VRK1 protein tested by SDS-PAGE gel. 0.5 µg of VRK1 protein was analyzed using SDS/PAGE followed by Western blot with an anti-GST antibody. 10 μg Log in to see 1 to 2 Days

VRK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , , ,

More Proteins for Vaccinia Related Kinase 1 (VRK1) Interaction Partners

Caenorhabditis elegans (C. elegans) Vaccinia Related Kinase 1 (VRK1) interaction partners

  1. vrk-1 has a role in early uterine development in Caenorhabditis elegans

  2. By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans.

  3. Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53 (show TP53 Proteins).

  4. Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.

Human Vaccinia Related Kinase 1 (VRK1) interaction partners

  1. that knockdown of VRK1 would inhibit the proliferation of glioma cells

  2. this study not only provides a resource for investigating the unidentified functions of VRK1/VRK3, but also an insight into the regulatory roles of VRK1/VRK3 in biological processes.

  3. Block the activation of the VRK1 promoter by Sox2 (show SOX2 Proteins).

  4. VRK1 and BANF1 (show BANF1 Proteins) yielded AUCs of 0.790 and 0.735, respectively.

  5. VRK1 AND VRK2 (show VRK2 Proteins) expression are predictive of tumor response to neoadjuvant chemoradiation therapy in rectal adenocarcinoma.

  6. VRK1 was lowly expressed in adherent MM cells and highly expressed in suspended cells. In addition, VRK1 was positively correlated with the proliferation of MM cells by regulating the expression of cell cycle-related protein, such as cyclinD1, CDK2 (show CDK2 Proteins) and p27(kip1 (show CDKN1B Proteins)).

  7. we conclude that VRK1 may be a candidate prognostic biomarker as well as a potential therapeutical target of hepatocellular carcinoma

  8. VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC (show FAM126A Proteins).

  9. VRK1 is a novel regulator of CBs (show CBS Proteins) dynamics and stability in cell cycle by protecting coilin (show COIL Proteins) from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.

  10. VRK1 regulation of NBS1 (show NBN Proteins) contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.

Mouse (Murine) Vaccinia Related Kinase 1 (VRK1) interaction partners

  1. VRK1 self-represses its activity to phosphorylate PXR (show NR1I2 Proteins) through cyclin-dependent kinase 2 (CDK2 (show CDK2 Proteins)) in high glucose conditions, resulting in the repression of the PCK1 (show PCK1 Proteins) gene. This PXR (show NR1I2 Proteins) phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2 (show CDK2 Proteins)-PXR (show NR1I2 Proteins)-PP2Calpha (show PPM1A Proteins)-SGK2 (show SGK2 Proteins) pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.

  2. VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (show APP Proteins)). APP (show APP Proteins) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (show APP Proteins)-dependent mechanism.

  3. Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.

  4. Protein kinase (show CDK7 Proteins) Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53 (show TP53 Proteins)-dependent manner.

  5. reduction of VRK1 activity causes a delay in meiotic progression during oogenesis

  6. VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance

  7. Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.

  8. These findings collectively support a role of VRK1 as a novel mitotic histone H3 (show HIST3H3 Proteins) kinase in mammals.

Vaccinia Related Kinase 1 (VRK1) Protein Profile

Protein Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Gene names and symbols associated with VRK1

  • vaccinia related kinase 1 L homeolog (vrk1.L)
  • vaccinia related kinase 1 (vrk1)
  • vaccinia related kinase 1 (VRK1)
  • Serine/threonine-protein kinase VRK1 (vrk-1)
  • vaccinia related kinase 1 (Vrk1)
  • 51PK protein
  • MGC64390 protein
  • MGC75762 protein
  • PCH1 protein
  • PCH1A protein
  • VRK1 protein
  • wu:fe16f06 protein
  • zgc:56266 protein

Protein level used designations for VRK1

vaccinia related kinase 1 , serine/threonine-protein kinase VRK1 , serine/threonine-protein kinase VRK1-like , vaccinia virus B1R-related kinase 1 , vaccinia-related kinase 1 , serine/threonine-protein kinase 51PK

380541 Xenopus laevis
394552 Xenopus (Silurana) tropicalis
423443 Gallus gallus
453148 Pan troglodytes
490848 Canis lupus familiaris
704798 Macaca mulatta
100195811 Salmo salar
100401786 Callithrix jacchus
100340357 Oryctolagus cuniculus
174004 Caenorhabditis elegans
7443 Homo sapiens
22367 Mus musculus
362779 Rattus norvegicus
618880 Bos taurus
100157930 Sus scrofa
406694 Danio rerio
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