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VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Additionally we are shipping Vaccinia Related Kinase 1 Antibodies (76) and Vaccinia Related Kinase 1 Kits (8) and many more products for this protein.
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This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
vaccinia related kinase 1
, serine/threonine-protein kinase VRK1
, serine/threonine-protein kinase VRK1-like
, vaccinia virus B1R-related kinase 1
, vaccinia-related kinase 1
, serine/threonine-protein kinase 51PK