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VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. Additionally we are shipping Vacuolar Protein Sorting 25 Homolog (S. Cerevisiae) Antibodies (71) and and many more products for this protein.
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ESCRT-II mutant tissues have deregulated signal transduction pathways, leading to tumorigenesis.
The non-cell autonomous induction of Yorkie (show YAP1 Proteins) is due to Notch (show NOTCH1 Proteins) signaling from vps25 mutant cells.
The vps25 protein, a component of the ESCRT machinery that regulates endocytic sorting of signaling receptors, as an unconventional type of Drosophila tumor suppressor.
The vps25 protein encodes a component of the ESCRT-II complex, which sorts membrane proteins into multivesicular bodies during endocytic trafficking to the lysosome.
Vps25(ENU/ENU) mutants survive until late gestation. Their limbs display FGF signaling enhancement and consequent hyperactivation of the FGF-SHH (show SHH Proteins) feedback loop causing polydactyly.
mammalian ESCRTII (show VPS28 Proteins) is made up of hVps25p, hVps22p, and hVps36p and may be redundant, cargo-specific, or not required for protein sorting at the multivesicular body
Results describe the mapping of multivesicular bodies with the second winged helix domain of human ESCRT-II (show VPS28 Proteins) subunit VPS25 and the first helix of ESCRT-III subunit VPS20 (show CHMP6 Proteins).
VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS25, VPS36, and SNF8 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL\; MIM 600284) (Slagsvold et al., 2005
vacuolar protein sorting 25 homolog (S. cerevisiae)
, vacuolar protein sorting-associated protein 25
, vacuolar protein sorting 25
, lethal (2) 44Db
, vesicle protein sorting 25
, vacuolar protein-sorting-associated protein 25
, ESCRT-II complex subunit VPS25
, Vacuolar protein-sorting-associated protein 25
, ELL-associated protein of 20 kDa
, dermal papilla-derived protein 9