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Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles.
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this study shows that Vps33B function is critical for determining the fate of signaling endosomes formed following pattern-recognition receptors activation
ARKID syndrome is caused by VPS33B mutation.
Vesicular trafficking complexes, containing VPS33B, are a novel class of modifiers of integrin function.
Novel splice site mutations in the VPS33B gene were identified in arthrogryposis, renal dysfunction, and cholestasis syndrome in Koreans.
Abnormal protein trafficking and impairment in multivesicular bodies maturation in Megakaryocytes underlie the alpha-granule deficiency in Vps33b(fl/fl (show FLT3LG Proteins))-ER(T2) mouse and ARC (show NOL3 Proteins) patients.
Case Report: neonate with ARC (show NOL3 Proteins) syndrome and high GGT (show GGT1 Proteins) cholestasis caused by VPS33B heterozygous mutations.
Case Report: novel mutations in VPS33B in Chinese patient with arthrogryposis, renal dysfunction and cholestasis syndrome.
Our data suggest that the ARC (show NOL3 Proteins) syndrome may result through impaired VIPAS39/SPE-39 (show VIPAR Proteins) and Vps33b-dependent endosomal maturation or fusion.
Evidence of genotype-phenotype correlation in ARC (show NOL3 Proteins) syndrome the VPS33B c.1225+5G>C mutation predicts a mild phenotype.
VPS16B (show VIPAR Proteins), similar to its binding partner VPS33B, is essential for megakaryocyte and platelet alpha-granule biogenesis.
SPE-39 (show VIPAR Proteins) due to tyrosine phosphorylation and ubiquitination on the function of Vps33B in the EGF (show EGF Proteins)-stimulated cells
knockdown of atp6ap2 (show ATP6AP2 Proteins) and vps33b had an additive negative effect on biliary development.
findings identify vps33b is a novel downstream target gene of the hnf6 (show ONECUT1 Proteins)/vhnf1 (show HNF1B Proteins) pathway that regulates bile duct development in zebrafish
VPS33B and VIPAR (show VIPAR Proteins) are essential for epidermal lamellar body biogenesis and function
VPS33B is vital for maintenance of mammalian structural and functional hepatocyte polarity.
this study shows that Vps33B is required in mouse macrophages for normal maturation of phagosomes and specialized endosomes that are induced upon pattern-recognition receptors activation
VPS33B interacted with the GDI2 (show GDI2 Proteins)/RAB11A (show RAB11A Proteins)/RAB27A (show RAB27A Proteins) pathway to regulate the trafficking of secretory proteins as exosomes.
The data presented in this study suggest that Vps33b is involved in alpha-granule formation possibly by facilitating the Vwf (show VWF Proteins)-positive vesicular trafficking to alpha-granule-related vacuoles in megakaryocytes.
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
vacuolar protein sorting 33B
, vacuolar protein sorting-associated protein 33B
, vacuolar protein sorting 33 homolog B (yeast)
, vacuolar protein sorting 33B (yeast homolog))
, vacuolar protein sorting-associated protein 33B-like
, vacuolar protein sorting homolog r-vps33b
, vacuolar sorting protein 33b