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VPS36, VPS22 (SNF8\; MIM 610904), and VPS25 (MIM 610907) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins.
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RAB27A (show RAB27A Proteins), RAB27B (show RAB27B Proteins) and VPS36 are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A (show RAB27A Proteins), RAB27B (show RAB27B Proteins) and VPS36, with RAB27A (show RAB27A Proteins) and RAB27B (show RAB27B Proteins) being dependent on VPS36.
mammalian ESCRTII (show VPS28 Proteins) is made up of hVps25p, hVps22p, and hVps36p and may be redundant, cargo-specific, or not required for protein sorting at the multivesicular body
Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich.
presentation of the complex structure of Eap45 GLUE and ubiquitin at 3.35 A resolution, which explains the previously uncharacterized mechanism of Ub recognition by mammalian ESCRT-II (show VPS28 Proteins)
VPS36 is essential for a proper endosomal sorting pathway and for vacuolar biogenesis in Arabidopsis.
vps36 mutations increase apoptotic resistance, but have little effect on non-autonomous proliferation.
VPS36, VPS22 (SNF8\; MIM 610904), and VPS25 (MIM 610907) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS36, VPS22, and VPS25 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL\; MIM 600284) (Slagsvold et al., 2005
ELL-associated protein of 45 kDa
, ESCRT-II complex subunit VPS36
, vacuolar protein-sorting-associated protein 36
, vacuolar protein sorting-associated protein 36
, vacuolar protein sorting 36 homolog (S. cerevisiae)
, Vacuolar protein-sorting-associated protein 36
, vacuolar protein-sorting-associated protein 36-like
, vacuolar protein sorting 36
, lethal (3) L5212
, LOW QUALITY PROTEIN: vacuolar protein-sorting-associated protein 36