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VPS52 encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene.
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Loss of heterozygosity and stop-gain mutation of VPS52 were found in gastric cancer.
These data demonstrate that the beneficial properties of SFN (show SFN Antibodies) extend beyond activation of the KEAP1 (show KEAP1 Antibodies)-Nrf2 (show GABPA Antibodies)-ARE system and warrant further interrogation given the current use of this agent in multiple clinical trials
our data indicate that cisplatin resistance in HOCCs is partially attributable to their high expression of p62 (show GTF2H1 Antibodies), which plays an important role in preventing ROS (show ROS1 Antibodies) stress-induced apoptosis by regulating the Keap1 (show KEAP1 Antibodies)-Nrf2 (show GABPA Antibodies)-ARE signaling pathway.
Golgi-associated retrograde protein orchestrates retrograde transport from endosomes to the trans-Golgi network by promoting vesicle tethering and assembly of SNARE (show NAPA Antibodies) complexes in consecutive, independent steps.[Golgi associated retrograde protein]
Golgi associated retrograde protein complex, consisting of the Vps52, Vps53 (show VPS53 Antibodies), and Vps54 (show VPS54 Antibodies) proteins, shows significant conservation between various species but diversification and specialization result in important differences in human cells.
Missorting of cathepsin D (show CTSD Antibodies) in GARP (show CNGB1 Antibodies)-depleted cells results from accumulation of recycling MPRs in a population of light, small vesicles downstream of endosomes.
This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18.
SAC2 suppressor of actin mutations 2-like protein
, vacuolar protein sorting-associated protein 52 homolog