anti-Vpr (HIV-1) Binding Protein (VPRBP) Antibodies

Component of the Cul4a-Rbx1-Ddb1-Vprbp/Dcaf1 E3 ubiquitin-protein ligase complex, Vprbp/Dcaf1 may function as the substrate recognition module within this complex (By similarity). Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
VPRBP 315987  
VPRBP 9730 Q9Y4B6
VPRBP 321006 Q80TR8
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Top anti-VPRBP Antibodies at antibodies-online.com

Showing 10 out of 25 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IP, WB 0.1 mL Log in to see 7 to 9 Days
$556.31
Details
Human Rabbit Un-conjugated IP, WB 0.1 mL Log in to see 7 to 9 Days
$556.31
Details
Human Rabbit Un-conjugated IHC, WB ABIN6272857 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of HEK-293 cells, using VPRBP antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry-Paraffin: VprBP Antibody  - Staining of human testis shows moderate cytoplasmic positivity in Leydig cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: VprBP Antibody  - Staining of human cell line CACO-2 shows localization to nucleus & nucleoli fibrillar center. Immunohistochemistry-Paraffin: VprBP Antibody  - Staining of human kidney shows strong cytoplasmic positivity in renal tubules. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human urinary bladder with VPRBP polyclonal antibody  shows moderate cytoplasmic positivity in urothelial cells. 100 μL Log in to see 11 to 12 Days
$460.00
Details
Chicken Rabbit Un-conjugated IP, WB   100 μL Log in to see 7 to 9 Days
$595.83
Details
Cow Rabbit Un-conjugated IP, WB   100 μL Log in to see 7 to 9 Days
$595.83
Details
Human Rabbit Un-conjugated ICC, IF Immunocytochemistry/Immunofluorescence: VprBP Antibody  - Staining of human cell line U-2 OS shows localization to nucleus & nucleoli fibrillar center. 100 μL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated ELISA, FACS, IHC, IP, WB   100 μg Log in to see 13 to 16 Days
$407.69
Details

Top referenced anti-VPRBP Antibodies

  1. Human Polyclonal VPRBP Primary Antibody for IP, WB - ABIN438378 : Salsman, Jagannathan, Paladino, Chan, Dellaire, Raught, Frappier: Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response. in Journal of virology 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal VPRBP Primary Antibody for IP, WB - ABIN438377 : Huang, Chiang, Lin, Chiou, Chow: HIV-1 Vpr triggers mitochondrial destruction by impairing Mfn2-mediated ER-mitochondria interaction. in PLoS ONE 2012 (PubMed)

More Antibodies against VPRBP Interaction Partners

Human Vpr (HIV-1) Binding Protein (VPRBP) interaction partners

  1. Data suggest that HIV-1 vpr mediates polyubiquitination of HLTF (show HLTF Antibodies) by directly loading it onto C-terminal WD40 domain (show DCAF12L2 Antibodies) of DCAF1 in complex the CRL4, an E3 ubiquitin ligase (show MUL1 Antibodies). (vpr = vpr gene product of Human immunodeficiency virus 1; HLTF (show HLTF Antibodies) = human helicase like transcription factor (show HLTF Antibodies); DCAF1 = human Vpr (HIV-1) binding protein; CRL4 = human E3 ubiquitin ligase (show MUL1 Antibodies) CRL4)

  2. The study suggests that DCAF1 is involved in hepatitis C virus (HCV) replication through regulation of miR (show MLXIP Antibodies)-122, and thus provides new insights into the interaction between HCV and the host cell.

  3. RNA interference-mediated knockdown of differentially regulated host factors identified Vpr binding protein (VprBP) as proviral host factor because its downregulation inhibited efficient propagation of seasonal influenza A virus.

  4. High VPRBP expression is associated with high-grade serous ovarian cancer.

  5. Data show that neurofibromin 2 (Merlin (show NF2 Antibodies)) suppresses proliferation and adhesion, at least partly, through inhibiting kinase suppressor of Ras 1 (KSR1 (show KSR1 Antibodies)) and DCAF1 protein.

  6. Together, these results characterize a novel postintegration restriction of HIV-1 replication in monocyte-derived dendritic cells and show that the interaction of Vpr with the DCAF1/DDB1 E3 ubiquitin ligase (show MUL1 Antibodies) complex and the yet-to-be-identified host factor might alleviate this restriction by inducing transcription from the viral long terminal repeat.

  7. This study presents the crystal structure of the DDB1-DCAF1-HIV-1-Vpr-uracil-DNA glycosylase (show UNG Antibodies) (cyclin U (show CCNO Antibodies)) complex.

  8. VprBP transcription was repressed by cellular miRNA-1236, which contributes to HIV-1 restriction in monocytes. miR (show MLXIP Antibodies)-1236 inhibitors enhanced translation of VprBP and promoted infection. miR (show MLXIP Antibodies)-1236 mimetics suppressed translation of VprBP.

  9. MCM10 (show MCM10 Antibodies) is the natural substrate of the Cul4-DDB1[VprBP] E3 ubiquitin ligase (show MUL1 Antibodies) whose degradation is regulated by VprBP, but Vpr enhances the proteasomal degradation of MCM10 (show MCM10 Antibodies) by interacting with VprBP.

  10. Vpr downregulated APOBEC3G (show APOBEC3G Antibodies) through Vpr-binding protein (VprBP)-mediated proteasomal degradation, and further confirmed that the reduction of APOBEC3G (show APOBEC3G Antibodies) encapsidation associated with Vpr was due to Vpr's degradation-inducing activity.

Mouse (Murine) Vpr (HIV-1) Binding Protein (VPRBP) interaction partners

  1. DCAF1 is required for T-cell expansion and function during anti-viral and autoimmune responses.

  2. VprBP Is Required for Efficient Editing and Selection of Igkappa+ B Cells, but Is Dispensable for Iglambda+ and Marginal Zone B Cell Maturation (show TNFRSF17 Antibodies) and Selection

  3. CRL4(VPRBP) ubiquitin ligase is a guardian of female reproductive life in germ cells and a maternal reprogramming factor after fertilization.

  4. multi-subunit cullin RING E3 ligase complex VprBP/DDB1/Cul4A (show CUL4A Antibodies)/Roc1 (show RIT1 Antibodies) associates with full-length RAG1 (show RAG1 Antibodies) through VprBP

  5. Data show that human immunodeficiency virus type 1 Vpr-binding protein VprBP binds stoichiometrically with DDB1 through its WD40 domain (show DCAF12L2 Antibodies) and through DDB1 to CUL4A (show CUL4A Antibodies), subunits of the COP9 (show COPS8 Antibodies)/signalsome.

VPRBP Antigen Profile

Protein Summary

Component of the Cul4a-Rbx1-Ddb1-Vprbp/Dcaf1 E3 ubiquitin-protein ligase complex, Vprbp/Dcaf1 may function as the substrate recognition module within this complex (By similarity). Associated with chromatin in a Ddb1-independent and cell cycle- dependent manner, Vprbp/Dcaf1 is recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis (By similarity).

Gene names and symbols associated with VPRBP

  • DDB1 and CUL4 associated factor 1 (Dcaf1) antibody
  • DDB1 and CUL4 associated factor 1 (DCAF1) antibody
  • protein VPRBP (LOC100175926) antibody
  • Vpr (HIV-1) binding protein (vprbp) antibody
  • DDB1 and CUL4 associated factor 1 (dcaf1) antibody
  • AI447437 antibody
  • B930007L02Rik antibody
  • DCAF1 antibody
  • mKIAA0800 antibody
  • RGD1305176 antibody

Protein level used designations for VPRBP

protein VPRBP , Vpr (HIV-1) binding protein , Vpr-binding protein , HIV-1 Vpr binding protein-like , HIV-1 Vpr binding protein , protein VPRBP-like , DDB1 and CUL4 associated factor 1 , DDB1- and CUL4-associated factor 1 , HIV-1 Vpr-binding protein , vpr-interacting protein

GENE ID SPECIES
315987 Rattus norvegicus
415921 Gallus gallus
470820 Pan troglodytes
700596 Macaca mulatta
785711 Bos taurus
100021242 Monodelphis domestica
100061218 Equus caballus
100075187 Ornithorhynchus anatinus
100175926 Ciona intestinalis
100333081 Danio rerio
100343053 Oryctolagus cuniculus
100448638 Pongo abelii
100475880 Ailuropoda melanoleuca
100519566 Sus scrofa
100545803 Meleagris gallopavo
100565954 Anolis carolinensis
100598513 Nomascus leucogenys
9730 Homo sapiens
321006 Mus musculus
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