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WDR5 encodes a member of the WD repeat protein family. Additionally we are shipping WDR5 Proteins (13) and many more products for this protein.
Showing 10 out of 99 products:
Human Monoclonal WDR5 Primary Antibody for ELISA, WB - ABIN969456
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Show all 2 Pubmed References
we found evidence that Setd1b (show SETD1B Antibodies), a maternally provided methyltransferase, is required for organizer gene expression. Our findings indicate that Wdr5-mediated H3K4 trimethylation plays a part in the organizer formation and dorsal axis development that are controlled by the maternal Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway.
The WDR5 is essential for vertebrate development, in that WDR5-depleted X. laevis tadpoles exhibit a variety of developmental defects and abnormal spatial Hox (show MSH2 Antibodies) gene expression.
we demonstrate for the first time that targeted expression of miR (show MLXIP Antibodies)-31-5p using a nonviral minicircle vector can serve as a novel approach for tumor miRNA therapy. Moreover, WDR5 may be a promising therapeutic target for NPC (show NPC1 Antibodies) treatment.
WDR5 may have oncogenic effect and WDR5-mediated H3K4 methylation plays an important role in leukemogenesis
WDR5 functions to sustain proper execution of DNA replication in pancreatic ductal adenocarcinoma cells, as previously suggested by replication stress studies involving MLL1, and c-Myc (show MYC Antibodies), also found to interact with WDR5.
This report documents a novel lncRNA, GClnc1, which may act as a scaffold to recruit the WDR5 and KAT2A (show KAT2A Antibodies) complex and modify the transcription of target genes. This study reveals that GClnc1 is an oncogenic lncRNA in human gastric cancer.
WDR5 shows a direct binding to the ZNF407 (show ZNF407 Antibodies) promoter.
Taken together, these data suggest that WDR5 is directly involved in p53 (show TP53 Antibodies) signaling pathway. Our studies provide a new insight into WDR5 functions in A549 cells.
Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (show CAPS Antibodies) (WDR5) and Mixed Lineage Leukemia (MLL (show MLL Antibodies))/SET1 (show SETD1A Antibodies) Family Proteins Specifically Inhibits MLL1 and SETd1A (show SETD1A Antibodies) Methyltransferase Complexes.
WDR5 over-expression is associated with poor breast cancer clinical outcome.
Results identify WDR5 as a key cofactor for N-Myc (show MYCN Antibodies)-regulated transcriptional activation and tumorigenesis and as a novel therapeutic target for MYCN (show MYCN Antibodies)-amplified neuroblastomas.
BIG3 may block the KPNAs (KPNA1 (show KPNA1 Antibodies), KPNA5 (show KPNA5 Antibodies), and KPNA6 (show KPNA6 Antibodies)) binding region(s) of PHB2 (show PHB2 Antibodies).
Cbx8 (show CBX8 Antibodies) associates with non-PRC1 (show PRC1 Antibodies) complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch (show NOTCH1 Antibodies) gene expression.
Wdr5 suppression also reduced IFNgamma, Il-1beta (show IL1B Antibodies), and TNFalpha (show TNF Antibodies) induced chemokine (show CCL1 Antibodies) gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis
results suggest that specific RNAs are integral inputs into the WDR5-MLL (show MLL Antibodies) complex for maintenance of the active chromatin state and embryonic stem cell fates
Data show that broad association of myc proto-oncogene protein MYC (show MYC Antibodies) with chromatin depends on interaction with the WD40 (show DCAF12L2 Antibodies)-repeat protein WDR5.
BIG3 inhibits insulin (show INS Antibodies) granule biogenesis and insulin (show INS Antibodies) secretion.
BIG3 negatively regulates insulin (show INS Antibodies) granule exocytosis by restricting insulin (show INS Antibodies) granule biogenesis without the release kinetics of individual granules at the final exocytotic steps being affected.
Depletion of KAT2B (show KAT2B Antibodies) or WDR5 decreased gluconeogenic gene expression.
analysis of a novel mechanism for epigenetic control of SMC (show DYM Antibodies)-marker gene expression during development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes
Study shows that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (show MLLT1 Antibodies) (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal.
Characterization of a novel WDR5-binding site that recruits RbBP5 (show RBBP5 Antibodies) through a conserved motif to enhance methylation of histone H3 (show HIST3H3 Antibodies) lysine 4 by mixed lineage leukemia protein-1.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
WD repeat domain 5
, WD repeat-containing protein 5
, BMP2-induced 3-kb gene protein
, SWD3, Set1c WD40 repeat protein, homolog
, WD-repeat protein 5
, WD repeat-containing protein BIG-3