anti-Wntless Homolog (Drosophila) (WLS) Antibodies

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. Additionally we are shipping WLS Proteins (5) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
WLS 79971 Q5T9L3
WLS 68151 Q6DID7
WLS 362065 Q6P689
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Top anti-WLS Antibodies at

Showing 10 out of 20 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Human Muscle 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-GPR177 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Liver Host:  Rabbit  Target Name:  WLS  Sample Tissue:  Human THP-1 Whole Cell  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated IHC, IHC (p), WB Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
Dog Rabbit Un-conjugated IHC, ELISA, WB 50 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB GPR177 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC, WB GPR177 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Skeletal muscle cells (arrows) in Human Muscle. Magnification is at 400X GPR177 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X 50 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Immunohistochemistry-Paraffin: GPR177/WLS Antibody  - Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in cytotrophoblastic cells. Immunocytochemistry/Immunofluorescence: GPR177/WLS Antibody  - Staining of human cell line AF22 shows localization to endoplasmic reticulum. 100 μL Log in to see 10 to 13 Days
Human Chicken Un-conjugated ICC, IHC, WB Western Blot analysis of WLS polyclonal antibody (1:2000) on HEK293 cell transfected with WLS-GFP. The 293 cell protein lysate contains both transfected WLS-GFP fusion protein (75KDa) and endogenous WLS protein (~55KDa). 100 μL Log in to see 11 to 12 Days
Human Rabbit Un-conjugated WB Western Blot: GRP177 Antibody [NBP1-59013] - Human Liver cell lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 8 to 11 Days

More Antibodies against WLS Interaction Partners

Human Wntless Homolog (Drosophila) (WLS) interaction partners

  1. GPR177 as a novel candidate for prognostic marker as well as a promising target for treatment of gastric cancer patients.

  2. Wls is differentially expressed in Intrahepatic Cholangiocarcinoma tissues and positively related to tumor stage and lymphatic invasion.

  3. This study provides a brand new evidence that GOLPH3 (show GOLPH3 Antibodies) promotes glioma cell proliferation by facilitating Wls recycling and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.

  4. These data showed that Wls was differentially expressed in HCC (show FAM126A Antibodies). Statistical analysis results suggest that Wls expression might increase as HCC (show FAM126A Antibodies) progresses.

  5. Wls-SEC12 (show PREB Antibodies) binding is stable, with the interacting interface biochemically mapped to cytosolic segments of individual proteins. Mutant Wls that fails to communicate with the COPII machinery cannot effectively support Wnt (show WNT2 Antibodies) secretion. These data suggest that formation of early Wnt (show WNT2 Antibodies) secretory vesicles is carefully regulated to ensure proper export of functional ligands

  6. we identified novel associations in WLS , ARHGAP1 (show ARHGAP1 Antibodies) , and 5' of MEF2C (show MEF2C Antibodies) ( P- values < 8x10 - 5 ; false discovery rate (FDR) q-values < 0.01) that were much more strongly associated with BMD (show BEST1 Antibodies) compared to the GWAS SNPs.

  7. Our data suggest that Wls protein is related to tumor metastasis and advanced TNM (show ODZ1 Antibodies) stage, and may be used as a new marker for prognosis of gastric carcinoma.

  8. These results indicate that WLS may play a role in invasion and metastasis of colorectal carcinoma.

  9. Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress.

  10. Genetic variation at the WLS and CCDC170 (show CCDC170 Antibodies)/ESR1 (show ESR1 Antibodies) loci were found to be significantly associated with bone mineral density

Mouse (Murine) Wntless Homolog (Drosophila) (WLS) interaction partners

  1. WLS role in the principal cells of the caput epididymidis during sperm maturation

  2. Wntless-deficient macrophages presented a unique subset of M2-like macrophages with anti-inflammatory, reparative, and angiogenic properties. Serial echocardiography studies revealed that mice lacking macrophage Wnt (show WNT2 Antibodies) secretion showed improved function and less remodeling 30 days after myocardial infarction.

  3. GPR177 in Sertoli cells had no apparent influence on spermatogenesis, whereas loss of GPR177 in germ cells disrupted spermatogenesis in an age-dependent manner.

  4. these results suggest that Gpr177 controls epithelial initiation of the fungiform placode through signaling via epithelial Wnt (show WNT2 Antibodies) ligands.

  5. regulates chondrogenesis and osteogenesis through both canonical and noncanonical Wnt (show WNT2 Antibodies) signaling

  6. Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than hematopoietic stem cells maintenance.

  7. Wls-mediated secretion of Wnt (show WNT2 Antibodies) ligands from the developing ventral body wall mesenchyme plays a critical role in fusion of the sternum and closure of the secondary body wall.

  8. eletion of the Wls gene in odontoblasts appears to reduce canonical Wnt (show WNT2 Antibodies) activity, leading to inhibition of odontoblast maturation and root elongation.

  9. The existence of spatial compartmentation in the rhombic lip and the interplay between Wls, Math1 (show ATOH1 Antibodies), and Pax6 (show PAX6 Antibodies) in the rhombic lip provides novel views of early cerebellar development.

  10. Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium

Zebrafish Wntless Homolog (Drosophila) (WLS) interaction partners

  1. the chaperon Wls and its ligands Wnt9a (show WNT9A Antibodies) and Wnt5b (show WNT5B Antibodies) are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb (show FRZB Antibodies) and Gpc4 (show GPC4 Antibodies).

  2. disruption of wls resulted in a significant loss of craniofacial bone, whereas lack of gpc4 (show GPC4 Antibodies), wnt5b (show WNT5B Antibodies) and wnt9a (show WNT9A Antibodies) resulted in severely delayed endochondral ossification.

  3. Homozygous wls mutants show a reduction in two cell populations that contribute to the presumptive dorsal habenulae.

  4. The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt (show WNT2 Antibodies) secretion in a variety of embryonic and adult tissue types.

Fruit Fly (Drosophila melanogaster) Wntless Homolog (Drosophila) (WLS) interaction partners

  1. Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress.

  2. The uncharacterized Drosophila protein Evi5 (show EVI5 Antibodies) was identified as an essential membrane trafficking regulator, and the molecular mechanism by which Evi5 (show EVI5 Antibodies) regulates BC migration was described.

  3. Syx1A, Rab11, and its effector Myosin5 were required for proper Evi vesicle release.

  4. DSNX3 regulates Wg secretion via retromer-dependent Wls recycling

  5. Por-mediated lipidation of the S239-equivalent residue is essential for the interaction with, and secretion by, Wls.

  6. we propose that Wntless represents an ancient partner for Wnts dedicated to promoting their secretion into the extracellular milieu.

  7. The function of Srt is restricted to events occurring within the Wg-producing cells, study shows that srt is not required for any aspect of Hedgehog (Hh) signal transduction, suggesting specificity of srt for the Wg pathway.

  8. Recent studies have identified Wntless (Wls) and the retromer complex as essential components involved in Wnt signaling.

  9. Wg, clathrin-mediated endocytosis and retromer sustain a Wls traffic loop from the Golgi to the plasma membrane and back to the Golgi, thereby enabling Wls to direct Wnt (show WNT4 Antibodies) secretion.

  10. WntD, a recently characterized Drosophila Wnt family member, does not require Porcupine or Wntless/Evi/Sprinter for its secretion or signaling activity

WLS Antigen Profile

Protein Summary

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Gene names and symbols associated with WLS

  • wntless Wnt ligand secretion mediator (WLS) antibody
  • wntless homolog (Drosophila) (Wls) antibody
  • wntless Wnt ligand secretion mediator (Wls) antibody
  • wntless Wnt ligand secretion mediator (wls) antibody
  • wntless (wls) antibody
  • 5031439A09Rik antibody
  • AI173978 antibody
  • AI987742 antibody
  • C1orf139 antibody
  • CG6210 antibody
  • Dmel\\CG6210 antibody
  • evi antibody
  • Evi/Wls antibody
  • gpr117 antibody
  • gpr177 antibody
  • mig-14 antibody
  • MRP antibody
  • sb:cb610 antibody
  • srt antibody
  • Wls antibody
  • wls/evi antibody
  • wu:fb36d04 antibody
  • wu:fb44d10 antibody
  • wu:fb50c06 antibody
  • zgc:64091 antibody

Protein level used designations for WLS

G protein-coupled receptor 177 , integral membrane protein GPR177 , protein evenness interrupted homolog , protein wntless homolog , putative NF-kappa-B-activating protein 373 , putative NFkB activating protein 373 , EVI , CG6210-PA , CG6210-PB , evenness interrupted , sprinter , wls-PA , wls-PB

79971 Homo sapiens
68151 Mus musculus
362065 Rattus norvegicus
406420 Danio rerio
424707 Gallus gallus
528123 Bos taurus
39259 Drosophila melanogaster
611491 Canis lupus familiaris
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