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Plays a role in papillomavirus genes transcription..
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Highly related cDNAs Pbf (show PTTG1IP Proteins) and Gig1 interact with required element MyoD (show MYOD1 Proteins) core enhancer; they represents a new family of DNA binding proteins that may be components of transciptional pathways that regulate a number of developmental and physiologic processes.
ndrg1b and fam49ab are 2 new modulators of PTEN signaling that control lymphoid differentiation in the zebrafish thymus.
epigenomic profiling of clear cell renal cell carcinoma (show MOK Proteins) (ccRCC) establishes a compendium of somatically altered cis (show CISH Proteins)-regulatory elements, uncovering new potential targets including ZNF395. Loss of VHL (show VHL Proteins), a ccRCC signature event, causes pervasive enhancer malfunction, with binding of enhancer-centric HIF2a (show EPAS1 Proteins) and recruitment of histone acetyltransferase p300 (show EP300 Proteins) at preexisting lineage-specific promoter-enhancer complexes
The transcriptional activation of CXCL10 (show CXCL10 Proteins) and CXCL11 (show CXCL11 Proteins) by ZNF395 was abolished after inhibition of IKK (show CHUK Proteins) by BMS-345541, which increased the stability of ZNF395. ZNF395 encodes at least two motifs that mediate the enhanced degradation of ZNF395 in response to IKK (show CHUK Proteins) activation. Thus, IKK (show CHUK Proteins) is required for ZNF395-mediated activation of transcription and enhances its turn-over to keep the activity of ZNF395 low.
miR (show MLXIP Proteins)-525-3p promotes liver cancer cell migration and invasion by directly targeting ZNF395.
IkBalpha kinase (IKK (show CHUK Proteins))-signaling is necessary to allow ZNF395 to activate transcription and simultaneously enhances its proteolytic degradation.
Studies indicate that ZNF395 was strongly expressed in adipocytes, and suggest a role for ZNF395 as a modulator of adipogenesis.
ZNF395 coordinate the transcriptional regulatory pathway with PPARG2 (show PPARG Proteins), which may be necessary for the genesis of adipocytes.
HDBP1 (show SLC2A4RG Proteins) and HDBP2 are novel transcription factors shuttling between nucleus and cytoplasm and bind to the specific GCCGGCG, which is an essential cis (show CISH Proteins)-element for HD gene expression in neuronal cells
PBF (show PTTG1IP Proteins) is a new cellular factor mediating the effects of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling and 14-3-3 (show YWHAQ Proteins) on cell growth
PBF (show PTTG1IP Proteins) binds to SAP30 (show SAP30 Proteins) and represses transcription via recruitment of the HDAC1 (show HDAC1 Proteins) co-repressor complex
colocalization of PBF (show PTTG1IP Proteins) and Scythe/BAT3 (show BAT3 Proteins) in the nucleus might be an important factor for survival of osteosarcoma cells.
Plays a role in papillomavirus genes transcription.
papillomavirus regulatory factor
, zinc finger protein 395
, HD gene regulatory region-binding protein 2
, HD-regulating factor 2
, Huntington's disease gene regulatory region-binding protein 2
, huntington disease gene regulatory region-binding protein 2
, papillomavirus regulatory factor 1
, papillomavirus regulatory factor PRF-1
, papillomavirus-binding factor