anti-Zinc Finger Protein 521 (ZNF521) Antibodies

Transcription factor that can both act as an activator or a repressor depending on the context. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ZNF521 307579  
ZNF521 25925 Q96K83
ZNF521 225207 Q6KAS7
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Top anti-Zinc Finger Protein 521 Antibodies at antibodies-online.com

Showing 10 out of 55 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: ZNF521 Antibody  - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm. Immunohistochemistry-Paraffin: ZNF521 Antibody  - Staining of human placenta shows nuclear and cytoplasmic positivity in trophoblastic cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ICC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$375.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-ZNF521 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.1 mg Log in to see 4 to 8 Days
$474.10
Details
Human Rabbit Un-conjugated EIA, IHC (p)   0.1 mg Log in to see 4 to 8 Days
$474.10
Details
Human Rabbit Un-conjugated ELISA, IHC Immunohistochemistry analysis of ZNF521 in human kidney tissue with ZNF521 polyclonal antibody  at 5 ug/mL. 100 μg Log in to see 11 to 12 Days
$356.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry-Paraffin: ZNF521 Antibody  - Staining of human placenta shows nuclear positivity in trophoblastic cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ELISA, ICC, WB Immunocytochemical anyalysis of HeLa cells with ZNF521 polyclonal antibody  at 2.5 ug/mL. Western blot analysis of HeLa cell lysate with ZNF521 polyclonal antibody  at 1 ug/mL in (1) the absence and (2) the presence of blocking peptide. 100 μg Log in to see 11 to 12 Days
$356.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of ZNF521 in HeLa cell lysate with ZNF521 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide. 0.1 mg Log in to see 2 to 3 Days
$360.00
Details

Top referenced anti-Zinc Finger Protein 521 Antibodies

  1. Human Polyclonal ZNF521 Primary Antibody for ICC, IF - ABIN4367327 : Spina, Filocamo, Iaccino, Scicchitano, Lupia, Chiarella, Mega, Bernaudo, Pelaggi, Mesuraca, Pazzaglia, Semenkow, Bar, Kool, Pfister, Bond, Eberhart, Steinkühler, Morrone: Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells. in Oncotarget 2013 (PubMed)

More Antibodies against Zinc Finger Protein 521 Interaction Partners

Human Zinc Finger Protein 521 (ZNF521) interaction partners

  1. Performance metrics were used to select SNPs in stage 1, which were then genotyped to another dataset (stage 2). Four SNPs (CPXM2 rs2362967, APOC1 rs4420638, ZNF521 rs7230380, and rs12965520) were identified for LOAD by both traditional P-values (without correcting for multiple tests) and performance metrics.

  2. IHC based post-Ki67 levels may have distinct predictive power compared with the naive IHC Ki67.

  3. knockdown of ZNF521 reduced proliferation in human leukemia cell lines possessing MLL-AF9 translocations

  4. two multi-zinc finger transcription cofactors named ZNF423 and ZNF521 have been characterised as potent inhibitors of EBF1 and are emerging as potentially relevant contributors to the development of B-cell leukaemias

  5. Data show that zinc finger protein 521 (ZNF521) can function as a repressor of osteoblastic differentiation of bone marrow mesenchymal stem cells (bmMSCs).

  6. Newly discovered ZNF521-molecular partners of potentially relevant functional role, such as ZNF423, Spt16, Spt5, were discovered and validated by Western blotting.

  7. Data strongly support the notion that ZNF521, through the recruitment of the NuRD complex, contributes to the clonogenic growth, migration and tumorigenicity of medulloblastoma cells.

  8. Data show that ZNF521 can antagonize B-cell development and support the notion that it may contribute to conserve the multipotency of primitive lympho-myeloid progenitors by preventing or delaying their EBF1-driven commitment toward the B-cell lineage.

  9. Zinc finger protein 521, a new player in bone formation.

  10. EHZF is likely to play a relevant role in the control of human hematopoiesis and might be implicated in the development of hematopoietic malignancies.

  11. A review of possible roles for ZNF521 in development, stem cell regulation and oncogenesis.

  12. ZNF521 modulates erythroid cell differentiation through direct binding with GATA-1.

  13. Enhanced resistance of target cells to NK cell-mediated cytotoxicity was induced by enforced expression of EHZF in the cervical carcinoma cell line HeLa and in the B lymphoblastoid cell line IM9

Mouse (Murine) Zinc Finger Protein 521 (ZNF521) interaction partners

  1. The pre-B-cell receptor (pre-BCR) signaling molecules BLNK, BTK and BANK1 were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR signaling pathway.

  2. these results identify ZNF521/ZFP521 as a critical regulator of HSC function, which facilitates MLL-AF9-mediated leukemic disease in mice.

  3. links between dysregulated Zfp521 and B-cell survival

  4. Here we demonstrate that the transcription factors SPI1 (PU.1) and HOXC13 synergistically regulate Zfp521 expression, and identify the regions of the Zfp521 promoter required for this transcriptional activity. We also show that SPI1 and HOXC13 activate Zfp521 in a dose-dependent manner.

  5. Data suggest a facilitated approach for establishing human neural stem cells (NSCs) through zinc finger protein 521 (Zfp521)-driven conversion of fibroblasts.

  6. it is concluding that an enhanced expression of Fndc5 in neural progenitor cells is stimulated by Zfp521 overexpression in these cells

  7. Data show that zinc finger protein 521 (ZNF521) overexpression repressed osteoblastic differentiation of C3H10T1/2 cells.

  8. Runx1-dependent transcription factor gene Zfp521 is expressed in, and required for establishing molecular features that define, mechanoreceptors.

  9. the data suggest that Zfp521 is a cell fate switch critical for BMP-induced osteoblast commitment and identify Zfp521 as the intrinsic repressor of Zfp423 and hence of adipocyte commitment during BMP-induced mesenchymal precursor differentiation.

  10. the interplay between Zfp521 and Ebf1 is identified as a novel rheostat for bone homeostasis.

  11. Reduction of Zfp521 enhances adipogenic potential in vivo.

  12. Zfp521 is a nuclear protein with 30 Kruppel-like zinc fingers mediating multiple protein-protein interactions, and regulates transcription in diverse tissues and organs.

  13. we found the expression of Zfp521 declined with the neural differentiation of bone marrow mesenchymal stem cells, and miR-9 could promote the neural differentiation via targeting Zfp521.

  14. This study provides the first genetic evidence that Zfp521 is required downstream of PTHR1 signaling to act on chondrocyte proliferation, differentiation, and cell death.

  15. transition of ES cell differentiation from the epiblast state into neuroectodermal progenitors specifically depends on the cell-intrinsic expression and activator function of Zfp521

  16. The balance and HDAC3-dependent molecular interplay between Zfp521 and Runx2 contribute to the control of osteoblast differentiation, skeletal development, and bone homeostasis.

  17. Zfp521 is an important PTHrP target gene that regulates growth plate chondrocyte proliferation and differentiation.

  18. Evi3 encodes an EBFAZ-related Kruppel-like zinc finger protein. Evi3 expression could be detected at all stages of B-cell development. EVI3, not EBFAZ, is the member of this protein family that interacts with and regulates early b-cell factor in B cells.

  19. Evi3 misexpression initiates tumorigenesis by perturbing B-cell development via an interaction with Early B-cell Factor (EBF).

  20. ZNF521 modulates erythroid cell differentiation through direct binding with GATA-1.

Zinc Finger Protein 521 (ZNF521) Antigen Profile

Protein Summary

Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage\; this interaction preventing EBF1 to bind DNA and activate target genes.

Gene names and symbols associated with ZNF521

  • zinc finger protein 521 (Zfp521) antibody
  • zinc finger protein 521 (ZNF521) antibody
  • zinc finger protein 521 S homeolog (znf521.S) antibody
  • B930086A16Rik antibody
  • EHZF antibody
  • Evi3 antibody
  • Znf521 antibody

Protein level used designations for ZNF521

LYST-interacting protein 3 , early hematopoietic zinc finger protein , ecotropic viral integration site 3 protein

GENE ID SPECIES
307579 Rattus norvegicus
421083 Gallus gallus
490511 Canis lupus familiaris
538792 Bos taurus
25925 Homo sapiens
225207 Mus musculus
414550 Xenopus laevis
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