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Transcription factor that can both act as an activator or a repressor depending on the context. Additionally we are shipping and many more products for this protein.
Showing 10 out of 54 products:
Human Polyclonal ZNF521 Primary Antibody for ICC, IF - ABIN4367327
Spina, Filocamo, Iaccino, Scicchitano, Lupia, Chiarella, Mega, Bernaudo, Pelaggi, Mesuraca, Pazzaglia, Semenkow, Bar, Kool, Pfister, Bond, Eberhart, Steinkühler, Morrone: Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells. in Oncotarget 2013
Performance metrics were used to select SNPs in stage 1, which were then genotyped to another dataset (stage 2). Four SNPs (CPXM2 (show CPXM2 Antibodies) rs2362967, APOC1 (show APOC1 Antibodies) rs4420638, ZNF521 rs7230380, and rs12965520) were identified for LOAD by both traditional P-values (without correcting for multiple tests) and performance metrics.
IHC based post-Ki67 (show MKI67 Antibodies) levels may have distinct predictive power compared with the naive IHC Ki67 (show MKI67 Antibodies).
knockdown of ZNF521 reduced proliferation in human leukemia cell li (show FUT1 Antibodies)nes possessing MLL-AF9 transloca (show MLL Antibodies)tion (show MLLT3 Antibodies)s
two multi-zinc finger transcription cofactors named ZNF423 (show 104125 Antibodies) and ZNF521 have been characterised as potent inhibitors of EBF1 (show EBF1 Antibodies) and are emerging as potentially relevant contributors to the development of B-cell leukaemias
Data show that zinc finger protein 521 (ZNF521) can function as a repressor of osteoblastic differentiation of bone marrow mesenchymal stem cells (bmMSCs).
Newly discovered ZNF521-molecular partners of potentially relevant functional role, such as ZNF423 (show 104125 Antibodies), Spt16 (show SUPT16H Antibodies), Spt5 (show SUPT5H Antibodies), were discovered and validated by Western blotting.
Data strongly support the notion that ZNF521, through the recruitment of the NuRD complex, contributes to the clonogenic growth, migration and tumorigenicity of medulloblastoma cells.
Data show that ZNF521 can antagonize B-cell development and support the notion that it may contribute to conserve the multipotency of primitive lympho-myeloid progenitors by preventing or delaying their EBF1 (show EBF1 Antibodies)-driven commitment toward the B-cell lineage.
Zinc finger protein 521, a new player in bone formation.
EHZF is likely to play a relevant role in the control of human hematopoiesis and might be implicated in the development of hematopoietic malignancies.
The pre-B-cell receptor (pre-BCR (show BCR Antibodies)) signaling molecules BLNK (show BLNK Antibodies), BTK (show BTK Antibodies) and BANK1 (show BANK1 Antibodies) were positively regulated by the ZFP521 gene, leading to enhancement of the pre-BCR (show BCR Antibodies) signaling pathway.
these results identify ZNF521/ZFP521 as a critical regulator of HSC (show FUT1 Antibodies) function, which facilitates MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies)-mediated leukemic disease in mice.
links between dysregulated Zfp521 and B-cell survival
Here we demonstrate that the transcription factors SPI1 (show SPI1 Antibodies) (PU.1) and HOXC13 synergistically regulate Zfp521 expression, and identify the regions of the Zfp521 promoter required for this transcriptional activity. We also show that SPI1 (show SPI1 Antibodies) and HOXC13 activate Zfp521 in a dose-dependent manner.
Data suggest a facilitated approach for establishing human neural stem cells (NSCs) through zinc finger protein 521 (Zfp521)-driven conversion of fibroblasts.
it is concluding that an enhanced expression of Fndc5 (show FNDC5 Antibodies) in neural progenitor cells is stimulated by Zfp521 overexpression in these cells
Data show that zinc finger protein 521 (ZNF521) overexpression repressed osteoblastic differentiation of C3H10T1/2 cells.
Runx1 (show RUNX1 Antibodies)-dependent transcription factor gene Zfp521 is expressed in, and required for establishing molecular features that define, mechanoreceptors.
the data suggest that Zfp521 is a cell fate switch critical for BMP-induced osteoblast commitment and identify Zfp521 as the intrinsic repressor of Zfp423 and hence of adipocyte commitment during BMP-induced mesenchymal precursor differentiation.
the interplay between Zfp521 and Ebf1 (show EBF1 Antibodies) is identified as a novel rheostat for bone homeostasis.
Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage\; this interaction preventing EBF1 to bind DNA and activate target genes.
LYST-interacting protein 3
, early hematopoietic zinc finger protein
, ecotropic viral integration site 3 protein