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ZBTB33 encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. Additionally we are shipping ZBTB33 Proteins (4) and ZBTB33 Kits (2) and many more products for this protein.
Showing 10 out of 34 products:
Human Polyclonal ZBTB33 Primary Antibody for ICC, IF - ABIN4328014
Zhang, Gallup, Zlock, Feeling Chen, Finkbeiner, McNamara: Cigarette Smoke Mediates Nuclear to Cytoplasmic Trafficking of Transcriptional Inhibitor Kaiso through MUC1 and P120-Catenin. in The American journal of pathology 2016
Dyrk1A (show DYRK1A Antibodies) positively and selectively modulates p120-catenin (show CTNND1 Antibodies) protein levels, thus having an impact on p120-catenin (show CTNND1 Antibodies) and Kaiso (and canonical Wnt (show WNT2 Antibodies)) gene targets such as siamois and wnt11.
xKaiso plays an essential role as a global repressor of methylated genes during early vertebrate development.
propose that mutual inhibition by Kaiso/TCF3 (show TCF3 Antibodies) of their DNA-binding functions may be important in developmental or cancer contexts and acts as a regulatory node that integrates epigenetic and Wnt (show WNT2 Antibodies) signalling pathways
The major phenotypic defects associated with xKaiso depletion are premature transcription activation before the mid-blastula transition and concomitant activation of a p53 (show TP53 Antibodies)-dependent cell-death pathway
Kaiso is a bimodal modulator for Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
A role for Kaiso in the proliferation.
Suggest a role for Kaiso in the progression of pancreatic ductal adenocarcinomas, involving the epithelial mesenchymal transformation markers, E-cadherin (show CDH1 Antibodies) and Zeb1 (show ZEB1 Antibodies).
a novel mechanism by which ZBTB33 mediates the cyclin D1 (show CCND1 Antibodies)/cyclin E1 (show CCNE1 Antibodies)/RB1 (show RB1 Antibodies)/E2F (show E2F1 Antibodies) pathway, controlling passage through the G1 restriction point and accelerating cancer cell proliferation.
GR is a putative target gene of Kaiso.
Kaiso high expression correlated with invasion of prostate cancer.
Results show that Kaiso binding to unmethylated Kaiso binding site in the human ICR1 is necessary for ICR1 methylation maintenance and affects transcription rates of the lncRNA H19 (show NCKAP1 Antibodies).
Kaiso modulates HIF1A (show HIF1A Antibodies) gene expression by binding to the methylated HIF1A (show HIF1A Antibodies) promoter in a region proximal to the autoregulatory HIF-1 (show HIF1A Antibodies) binding site, primarily during hypoxia.
NF-kappaB (show NFKB1 Antibodies) response element, located close to the p53RE#1, mediates APAF1 (show APAF1 Antibodies) transcriptional repression by affecting interaction between KAISO and p53 (show TP53 Antibodies)
KAISO is a regulator of p53 (show TP53 Antibodies)-mediated transcription of CDKN1A and apoptotic genes
Data indicate that Kaiso protein participates in the regulation of beta-catenin (show CTNNB1 Antibodies) mRNA expression by interacting with p120-catenin (show CTNND1 Antibodies) in the lung cancer cell lines.
We also demonstrate that Kaiso inhibits Znf131 (show ZNF131 Antibodies) expression, raising the possibility that Kaiso and Znf131 (show ZNF131 Antibodies) act to fine-tune target gene expression. Together, our findings implicate Znf131 (show ZNF131 Antibodies) as a co-regulator of Kaiso-mediated biological processes.
Kaiso and Sox10 (show SOX10 Antibodies) sequentially interact with Tcf7l2 (show TCF7L2 Antibodies) to coordinate the maturation of oligodendrocyte.
Study revealed the involvement of the Zbtb33 gene and, probably, the Kaiso protein in the regulation of locomotion and brain morphology in mice
a mechanistic link between E-cadherin (show CDH1 Antibodies) loss and subsequent control of Rho-driven anoikis resistance through p120 (show CTNND1 Antibodies)- and Kaiso-dependent expression of Wnt11 (show WNT11 Antibodies), is reported.
S100A3 (show S100A3 Antibodies) is a new target gene of Kaiso in mouse skin
ZBTB33 expression may elicit intestinal inflammation by antagonizing p120ctn (show CTNND1 Antibodies) function.
derepressed Bcl6 (show BCL6 Antibodies) expression may be responsible for increases in germinal centers cell proliferation and splenomegaly of Kaiso knockout mice.
KAISO, similar to SMRT, accelerates the cell cycle and increases fat accumulation upon knockdown, identifying KAISO as an adipogenic repressor that likely modulates the mitotic clonal expansion phase of this process.
Znf131 (show ZNF131 Antibodies) is a transcriptional activator, a less common function of POZ-ZF proteins, that is negatively regulated by its heterodimerization partner Kaiso.
These results provide the first experimental evidence that rapsyn (show RAPSN Antibodies) is a direct sequence-specific target of Kaiso and delta-catenin (show CTNND2 Antibodies).
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
DNA-methylation dependent transcriptional repressor Kaiso-like protein
, transcriptional regulator Kaiso
, zinc finger and BTB domain-containing protein 33
, kaiso transcription factor
, zinc finger transcription factor Kaiso