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acts as a transcriptional repressor\; may play a role in osteoclastogenesis [RGD, Feb 2006].. Additionally we are shipping ZBTB7A Antibodies (107) and ZBTB7A Kits (11) and many more products for this protein.
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ZBTB7A is increased in cisplatin-resistant osteosarcoma cells and elevated ZBTB7A inhibits cisplatin-induced apoptosis by repressing LINC00473 expression.
Our data suggest that ZBTB7A is involved in the development and progression of colorectal carcinoma
Results indicate the reverse association between the expression of ZBTB7A and the tumorigenicity of nasopharyngeal carcinoma (NPC (show NPC1 Proteins)).
Alveolar macrophages deficient in Zbtb7a failed to induce antibody and T cell responses.
Variants of ZBTB7A (LRF) and its beta-globin (show HBB Proteins) gene cluster binding motifs in sickle cell anemia/
This analysis complements the understanding of the mutational landscape of core binding factor (show CBFB Proteins) acute myeloid leukemia (show BCL11A Proteins), and has led to the identification of novel ZBTB7A mutations in t(8;21) acute myeloid leukemia (show BCL11A Proteins) subgroup.
Lymphoma-related factor mediates the protease-activated receptor 2 (show F2RL1 Proteins)-suppressed p53 (show TP53 Proteins) expression in the cancer cells and binds DAP5 (show EIF4G2 Proteins) to interfere with the gene transcription of p53 (show TP53 Proteins) in colon cancer cells.
Our study uncovers the loss-of-function mutation in ZBTB7A as a novel mechanism causing elevated glycolysis in human cancer, which carries important therapeutic implication.
Mutation in ZBTB7A is associated with core-binding factor (show CBFB Proteins) acute myeloid leukemia (show BCL11A Proteins).
Zbtb7a knockdown by siRNA suppressed cell proliferation and i (show MLXIP Proteins)nduced G1 cell cycle arrest and apoptosis (show MLXIP Proteins) in lung cancer cells. Furthermore, miR-125a expression showed a negative correlation with Zbtb7a expression in non-small cell lung cancer tissues.
LRF is expressed mainly in oligodendrocytes but is not required for oligodendrocyte repopulation of demyelinated lesions. Furthermore, LRF can modulate the extent of remyelination, potentially by contributing to interactions regulating transcription
this study shows that Thpok (show ZBTB7B Proteins) and LRF are redundantly required to maintain the size and functions of the postthymic Treg pool
This study identified Zbtb7a as a novel direct target for miR (show MLXIP Proteins)-125a by gene expression profiling in miR (show MLXIP Proteins)-125a knockout mice combined with bioinformatics target prediction, and elucidated the role of Zbtb7a in oncogenesis.
This study demonstrated an unexpected transcription-independent function for LRF in the classical non-homologous end joining pathway of double-strand break repair.
LRF short hairpin RNA suppressed the expression of LRF protein in a glioma cell line compared to the negative control vector-transfected glioma cells. LRF knockdown also reduced cell viability and enhanced cisplatin-induced apoptosis in glioma cells.
Data indicate that transcription factors Thpok (show ZBTB7B Proteins) and LRF redundantly maintain CD4 (show CD4 Proteins)+ lineage integrity.
Findings demonstrate that Pokemon suppresses Sprouty1 expression through a miR (show MLXIP Proteins)-21-mediated mechanism, affecting the growth and proliferation of liver cancer cells.
Data show that Notch1 (show NOTCH1 Proteins)/Dll4 (show DLL4 Proteins)-mediated T-cell instructive signals to long-term HSCs (LT-HSCs) are suppressed by Lrf expression in the bone marrow microenvironment.
These results support a critical role for LRF in transcriptional control of differentiation in oligodendrocyte lineage cells during developmental myelination in the CNS.
acts as a transcriptional repressor\; may play a role in osteoclastogenesis
zinc finger and BTB domain containing 7A
, similar to zinc finger and BTB domain containing 36
, HIV-1 1st-binding protein 1
, HIV-1 inducer of short transcripts binding protein
, POK erythroid myeloid ontogenic factor
, POZ and Krueppel erythroid myeloid ontogenic factor
, TTF-I-interacting peptide 21
, factor binding IST protein 1
, factor that binds to inducer of short transcripts protein 1
, leukemia/lymphoma-related factor
, lymphoma related factor
, zinc finger and BTB domain containing 7A, HIV-1 inducer of short transcripts binding protein
, zinc finger and BTB domain-containing protein 7A
, zinc finger protein 857A
, leukemia/lymphoma related factor
, osteoclast-derived zinc finger protein
, leukemia/lymphoma related factor cLRF