Zyxin Proteins (ZYX)

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Additionally we are shipping Zyxin Antibodies (95) and Zyxin Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ZYX 7791 Q15942
Mouse ZYX ZYX 22793 Q62523
Rat ZYX ZYX 114636  
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Top Zyxin Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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Mammalian Cells Human DYKDDDDK-His Tag 100 μg Log in to see 2 to 3 Days
$1,490.50
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Escherichia coli (E. coli) Human His tag   100 μg Log in to see 15 to 18 Days
$720.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

ZYX Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,

More Proteins for Zyxin (ZYX) Interaction Partners

Caenorhabditis elegans (C. elegans) Zyxin (ZYX) interaction partners

  1. ZYX-1 is a conserved LIM domain-containing focal adhesion protein that regulates synapse maintenance in Caenorhabditis elegans

  2. The zyx-1 gene encodes two different isoforms, ZYX-1a and ZYX-1b, which exhibit different roles in dystrophin-dependent muscle degeneration in C. elegans

  3. DYC-1 interacts with ZYX-1, the homologue of the vertebrate focal adhesion LIM domain protein zyxin.

Fruit Fly (Drosophila melanogaster) Zyxin (ZYX) interaction partners

  1. results show that Zyxin is a functional antagonist of Expanded in growth control

  2. The motor domain of DmMyo20 could specifically bind to actin filaments in an ATP-independent manner and enhance the interaction between actin filaments and Zyx102, a downstream component of DmMyo20 in the Fat signaling pathway.

  3. Through epistasis tests, the requirement for Zyx is positioned within the Fat branch of Hippo signaling, downstream of Fat and Dco, and upstream of the Yorkie kinase Warts.

  4. Reduction of Zyx102 protein levels using RNA-interference results in lethality at the pharate adult stage.

Human Zyxin (ZYX) interaction partners

  1. Study findings identify zyxin as a physiological regulator of endothelial exocytosis through reorganizing local actin network in the final stage of exocytosis. Zyxin downregulation inhibits the secretion of VWF from human primary endothelial cells.

  2. these observations suggest that Zyxin promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8-mediated YAP activation.

  3. Increased zyxin expression is associated with asthma.

  4. VASP, zyxin and TES are tension-dependent members of focal adherens junctions independent of the alpha-catenin-vinculin module.

  5. Zyxin binding to Ptc2 is due to the interaction of Zyxin 2nd LIM-domain (530-590 aa) with the under-membrane region of the cytoplasmic C-terminus of Ptc2 (1159-1412 aa).

  6. ZYX gene may be aging-related gene and involved in Osteoporosis.

  7. key regulator of stretch-induced gene expression at the cellular level

  8. Matrix density alters zyxin phosphorylation, which limits peripheral process formation and extension in endothelial cells invading 3D collagen matrices.

  9. Zyxin, which is thought to be essential for tight cell-to-cell junctions, decreased 1.8-fold in TNF-alpha-treated human brain microvascular endothelial cells.

  10. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta.

  11. Zyxin is a novel target for beta-amyloid peptide activities in Alzheimer's disease.

  12. Zyxin is suggested to promote growth, migration and invasiveness of fibroblastic type oral squamous cell carcinoma cells by upregulating Rac1 and Cdc42.

  13. A stretch-induced signaling pathway in vascular cells leads to the activation of zyxin, a cytoskeletal protein specifically involved in transducing mechanical stimuli.

  14. RA-induced cancer cell cytotoxicity was significantly impaired by Zyxin or PTOV1. Overall, our findings suggest that Zyxin and PTOV1 should be considered as critical determinants in cancer therapy with retinoids

  15. Zyxin is a transforming growth factor-beta (TGF-beta)/Smad3 target gene that regulates lung cancer cell motility via integrin alpha5beta1.

  16. Zyxin phenotype is mediated by partners alpha-actinin and p130Cas and ensures that motile cells in a three-dimensional matrix explore the largest space possible in minimum time.

  17. Depletion of nectin-2 from L cells expressing E-cadherin results in a loss of zyxin localization to cell-cell contacts, demonstrating that the zyxin-nectin interaction plays a critical role in zyxin targeting to these sites.

  18. LIM domain of zyxin recruits zyxin to force-bearing sites at the leading edge of migrating cells

  19. When myosin II contractility was inhibited, the k(off) values for all three proteins changed rapidly, in a highly protein-specific manner: dissociation of vinculin from FAs was facilitated, whereas dissociation of paxillin and zyxin was attenuated.

  20. Findings suggest an unforeseen role for Zyxin in DNA damage-induced cell fate control through modulating the HIPK2-p53 signaling axis.

Mouse (Murine) Zyxin (ZYX) interaction partners

  1. Study findings identify zyxin as a physiological regulator of endothelial exocytosis through reorganizing local actin network in the final stage of exocytosis. Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF.

  2. these observations suggest that Zyxin promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8-mediated YAP activation.

  3. zyxin influences focal adhesion dynamics, that it recruits Tes and that this interaction is functional in regulating cell spreading.

  4. Zyxin contributes to the migratory and invasive phenotype evoked by Tead2.

  5. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta.

  6. paxillin and zyxin are LIM-domain adaptor proteins that are recruited to stress fiber strain sites

  7. Zyxin regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1beta.

  8. Zyxin is a transforming growth factor-beta (TGF-beta)/Smad3 target gene that regulates lung cancer cell motility via integrin alpha5beta1.

  9. a bipartite mechanism for stretch-induced actin remodeling involves mechanosensitive targeting of zyxin to actin stress fibers and localized recruitment of actin regulatory machinery

  10. Mice that lack zyxin function are viable and fertile and display no obvious histological abnormalities in any of the organs examined.Specifically, we evaluated blood platelet function, nervous system development, and skin architecture

  11. LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions

  12. Cooperates with Ena, vasodilator-stimulated phosphoprotein, and caldesmon to influence integrin-dependent cell motility and actin stress fiber remodeling.

  13. Data show that zyxin reorganizes actin fibers and enhances cell motility in response to TGF-beta1, thereby regulating EMT.

Xenopus laevis Zyxin (ZYX) interaction partners

  1. Zyxin binding to Ptc2 is due to the interaction of Zyxin 2nd LIM-domain (530-590 aa) with the under-membrane region of the cytoplasmic C-terminus of Ptc2 (1159-1412 aa).

  2. Zyxin inhibits Shh signaling during the CNS patterning in Xenopus laevis through interaction with Gli1

  3. These results are consistent with a possible role of Zyxin as a negative modulator of Xanf1 transcriptional repressing activity.

  4. binding of the LIM2 domain of zyxin with the Engrailed Homology 1 repressor domain of Xanf1 is responsible for the interaction of these proteins.

Zyxin (ZYX) Protein Profile

Protein Summary

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

Gene names and symbols associated with Zyxin Proteins (ZYX)

  • Zyxin (zyx-1)
  • Zyxin (Zyx)
  • zyxin (zyx)
  • zyxin (ZYX)
  • zyxin (EDI_201420)
  • zyxin (Zyx)
  • zyxin S homeolog (zyx.S)
  • 9530098H06Rik protein
  • BcDNA:LD06023 protein
  • CG32018 protein
  • DLim-1 protein
  • Dmel\\CG32018 protein
  • DmLIM-1 protein
  • ESP-2 protein
  • HED-2 protein
  • lim protein
  • Lim102EF protein
  • MGC145270 protein
  • R75157 protein
  • zgc:171680 protein
  • zyx protein
  • zyx102 protein
  • Zyx102EF protein
  • zyxin protein

Protein level used designations for Zyxin Proteins (ZYX)

ZYXin family member (zyx-1) , CG32018-PA , CG32018-PB , CG32018-PG , CG32018-PH , Zyx-PA , Zyx-PB , Zyx-PG , Zyx-PH , Zyx102EF , zyxin , hypothetical protein LOC779718 , zyxin-2

GENE ID SPECIES
174951 Caenorhabditis elegans
317824 Drosophila melanogaster
564246 Danio rerio
706407 Macaca mulatta
779718 Xenopus (Silurana) tropicalis
5914189 Entamoeba dispar SAW760
100011992 Monodelphis domestica
100219276 Taeniopygia guttata
7791 Homo sapiens
768226 Bos taurus
22793 Mus musculus
114636 Rattus norvegicus
482736 Canis lupus familiaris
100524720 Sus scrofa
418300 Gallus gallus
100049724 Xenopus laevis
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