gamma-Glutamyl Carboxylase (GGCX) ELISA Kits

GGCX encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Additionally we are shipping GGCX Antibodies (65) and GGCX Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
GGCX 2677 P38435
Anti-Mouse GGCX GGCX 56316 Q9QYC7
Anti-Rat GGCX GGCX 81716 O88496
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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.08 ng/mL   96 Tests Log in to see 13 to 16 Days

More ELISA Kits for GGCX Interaction Partners

Human gamma-Glutamyl Carboxylase (GGCX) interaction partners

  1. 2 causative GGCX mutations ( c.1889-6G>A and c.1657delA) from the first reported clinical case of a VKCFD patient. The intronic mutation c.1889-6G>A affects GGCX splicing. Functional characterization of these 2 mutations suggests that truncation of GGCX from its C-terminus affects not only substrate binding but also protein stability.

  2. impact of CYP4F2 (show CYP4F2 ELISA Kits), ABCB1 (show ABCB1 ELISA Kits), and GGCX polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation

  3. this systematic review suggests that there indeed may be genotype-phenotype correlations for GGCX-related phenotypes, which can guide patient counseling and management.

  4. 529 adults (n = 325 European-Americans, 204 Egyptians) on a stable warfarin dose were genotyped for GGCX rs12714145 and rs10654848, FPGS (show FPGS ELISA Kits) rs7856096, and STX1B (show STX1B ELISA Kits) rs4889606.

  5. GGCX c.2084+45G polymorphisms has a moderate effect on VKAs dose requirements in Slavic population from Central-Eastern Europe.

  6. Detected are ten mutations in the gamma-glutamyl carboxylase gene in patients with hereditary deficiency of vitamin K-dependent coagulation factors.

  7. The allele frequency for GGCX 12970 C > G is 1.43 in north Indians and did not have a significant bearing on the maintenance dose of acenocoumarol oral anticoagulant in cardiac valve replacement patients.

  8. GGCX mutation found in families with pseudoxanthoma elasticum with retinitis pigmentosa and cutis laxa.

  9. These findings indicate that individuals carrying the CYP2C19 (show CYP2C19 ELISA Kits) rs3814637CC or CYP2C9 (show CYP2C9 ELISA Kits) rs1057910AA or GGCX rs699664AA genotype needed higher warfarin doses in the Chinese population.

  10. In atrial fibrillation population in Xinjiang, patients with CT and TT genotypes in the gamma-glutamyl carboxylase gene rs259251 loci required significantly higher warfarin dose than those with CC genotype.

Mouse (Murine) gamma-Glutamyl Carboxylase (GGCX) interaction partners

  1. GGCX in osteoblasts functions to prevent abnormal mineralization in bone formation.

  2. findings suggest that GGCX expressed in osteoblasts is critical for the maintenance of blood glucose and WAT

  3. OCN is gamma-carboxylated by the gamma-carboxylase (GGCX) on three glutamic acid residues, a cellular process requiring reduction of vitamin K by a second enzyme, VKORC1 (show VKORC1 ELISA Kits).

  4. Ggcx(Deltaliver/Deltaliver) mice displayed bleeding diathesis.

  5. Effect of vitamin K-dependent protein precursor propeptide, vitamin K hydroquinone, and glutamate (show GRIN1 ELISA Kits) substrate binding on the structure and function of {gamma}-glutamyl carboxylase.

  6. These findings suggest a role for both the GGCX gene and the genetic background as well as dietary factors in modulating the phenotypic severity of Pseudoxanthoma elasticum caused by loss-of-function mutations in ABCC6 (show ABCC6 ELISA Kits).

  7. Analysis of a Ggcx(+/-) intercross revealed a partial developmental block with only 50% of expected Ggcx(-/-) offspring surviving to term, with the latter animals dying uniformly at birth of massive intra-abdominal hemorrhage

GGCX Antigen Profile

Antigen Summary

This gene encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GGCX

  • gamma-glutamyl carboxylase (GGCX) antibody
  • gamma-glutamyl carboxylase (ggcx) antibody
  • gamma-glutamyl carboxylase (GC) antibody
  • gamma-glutamyl carboxylase (sce5891) antibody
  • gamma-glutamyl carboxylase L homeolog (ggcx.L) antibody
  • gamma-glutamyl carboxylase (Ggcx) antibody
  • cb751 antibody
  • CG13927 antibody
  • dgammaC antibody
  • dGC antibody
  • Dmel\\CG13927 antibody
  • gammaC antibody
  • GGC antibody
  • ggcx antibody
  • si:ch1073-230p18.3 antibody
  • VKCFD1 antibody
  • zgc:158736 antibody

Protein level used designations for GGCX

gamma-glutamyl carboxylase , vitamin K-dependent gamma-carboxylase , peptidyl-glutamate 4-carboxylase , vitamin K gamma glutamyl carboxylase , CG13927-PA , CG13927-PB , GC-PA , GC-PB , gamma-glutamyl-carboxylase , gamma glutamyl carboxylase

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100144666 Xenopus (Silurana) tropicalis
100171564 Pongo abelii
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5810488 Sorangium cellulosum So ce56
444473 Xenopus laevis
2677 Homo sapiens
281190 Bos taurus
56316 Mus musculus
81716 Rattus norvegicus
475769 Canis lupus familiaris
443129 Ovis aries
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