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The protein encoded by GGCT catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis.
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GGCT is highly upregulated in HGSC tissues and associated with FIGO stage, lymph node metastasis and ascitic fluid volume. High expression of GGCT is associated with poor survival in HGSC patients.
Taken together, the results indicate that PHB2 (show PHB2 Proteins) plays a central role in p21 (show CDKN1A Proteins) upregulation following GGCT knockdown and as such may promote deregulated proliferation of cancer cells by suppressing p21 (show CDKN1A Proteins).
GGCT plays a critical role in glioma cell proliferation and may be a potential cancer therapeutic target.
GGCT is promising as a diagnostic marker and a therapeutic target for various cancers. This review summarizes these interesting findings.
G6PD (show G6PD Proteins), GGCT, IDH1 (show IDH1 Proteins), isocitrate dehydrogenase 2 (show IDH2 Proteins) (NADP+,mitochondrial) (IDH2 (show IDH2 Proteins)) and glutathione S-transferase pi 1(GSTP1 (show GSTP1 Proteins)), five of the critical components of GSH pathway, contribute to chemoresistance.
GGCT plays a critical role in lung cancer cell proliferation.
Transcriptional silencing of the C7orf24 gene in the non-malignant cells is elicited through heterochromatin formation in its promoter region.
increased expression of GGCT was a common event among invasive esophageal squamous cell carcinoma tissues regardless of the depth of invasion. Lymph node metastasis and tumor differentiation correlated with GGCT expression
C7orf24 has been recognized as a potent marker for bladder and breast cancers. Studies on the role of gamma-glutamylcyclotransferace may aid in the control of malignant transformation of these cancers.
GGCT may be a biomarker of tumors in a limited range of organs.
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, gamma-glutamyl cyclotransferase
, gamma-glutamyl cyclotransferase-like 1
, cytochrome c-releasing factor 21
, gamma -glutamyl cyclotransferase