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The protein encoded by GGCT catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. Additionally we are shipping gamma-Glutamylcyclotransferase Antibodies (63) and gamma-Glutamylcyclotransferase Kits (5) and many more products for this protein.
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Taken together, the results indicate that PHB2 (show PHB2 Proteins) plays a central role in p21 (show CDKN1A Proteins) upregulation following GGCT knockdown and as such may promote deregulated proliferation of cancer cells by suppressing p21 (show CDKN1A Proteins).
GGCT plays a critical role in glioma cell proliferation and may be a potential cancer therapeutic target.
GGCT is promising as a diagnostic marker and a therapeutic target for various cancers. This review summarizes these interesting findings.
G6PD (show G6PD Proteins), GGCT, IDH1 (show IDH1 Proteins), isocitrate dehydrogenase 2 (show IDH2 Proteins) (NADP+,mitochondrial) (IDH2 (show IDH2 Proteins)) and glutathione S-transferase pi 1(GSTP1 (show GSTP1 Proteins)), five of the critical components of GSH pathway, contribute to chemoresistance.
GGCT plays a critical role in lung cancer cell proliferation.
Transcriptional silencing of the C7orf24 gene in the non-malignant cells is elicited through heterochromatin formation in its promoter region.
increased expression of GGCT was a common event among invasive esophageal squamous cell carcinoma tissues regardless of the depth of invasion. Lymph node metastasis and tumor differentiation correlated with GGCT expression
C7orf24 has been recognized as a potent marker for bladder and breast cancers. Studies on the role of gamma-glutamylcyclotransferace may aid in the control of malignant transformation of these cancers.
GGCT may be a biomarker of tumors in a limited range of organs.
C7orf24 overexpression defines a subgroup of breast tumors with poor clinical outcome.
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, gamma-glutamyl cyclotransferase
, gamma-glutamyl cyclotransferase-like 1
, cytochrome c-releasing factor 21
, gamma -glutamyl cyclotransferase