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GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). Additionally we are shipping ARHGAP36 Proteins (2) and many more products for this protein.
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PKA inhibition by ARHGAP36 promotes derepression of the Hedgehog signalling pathway, thereby providing a simple rationale for the upregulation of ARHGAP36 in medulloblastoma.
We have reported here for the first time a reduced activity of both Rac1 and Cdc42 in human pheochromocytoma resection as well as tumor-associated expression changes of FARP1, ARHGEF1, and ARHGAP36
ARHGAP36 isoforms capable of Gli activation are up-regulated in a subset of human medulloblastomas.
Arhgap36 acts in a Smoothened-independent manner to promote the activation of full-length Gli proteins and induces the accumulation of Gli proteins in the primary cilium. Its ability to induce Gli-dependent transcription requires kinesin family member 3a and intraflagellar transport protein 88, proteins that are essential for ciliogenesis. Arhgap36 functionally and biochemically interacts with Suppressor of Fused.
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity).
rho GTPase-activating protein 36
, Novel RhoGAP domain containing protein
, Rho-GTPase-activating protein like protein
, Rho GTPase-activating protein 36