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GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). Additionally we are shipping ARHGAP36 Proteins (2) and many more products for this protein.
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PKA inhibition by ARHGAP36 promotes derepression of the Hedgehog (show SHH Antibodies) signalling pathway, thereby providing a simple rationale for the upregulation of ARHGAP36 in medulloblastoma.
We have reported here for the first time a reduced activity of both Rac1 and Cdc42 (show CDC42 Antibodies) in human pheochromocytoma resection as well as tumor-associated expression changes of FARP1 (show FARP1 Antibodies), ARHGEF1 (show ARHGEF1 Antibodies), and ARHGAP36
ARHGAP36 isoforms capable of (show SMO Antibodies)Gli activation are up-regulated in a subset of human medulloblas (show GLI1 Antibodies)tomas.
Arhgap36 acts in a Smoothened-independent manner to promote the activation of full-length Gli (show GLI1 Antibodies) proteins and induces the accumulation of Gli (show GLI1 Antibodies) proteins in the primary cilium. Its ability to induce Gli (show GLI1 Antibodies)-dependent transcription requires kinesin family member 3a (show KIF3A Antibodies) and intraflagellar transport protein 88, proteins that are essential for ciliogenesis. Arhgap36 functionally and biochemically interacts with Suppressor of Fused (show SUFUH Antibodies).
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity).
rho GTPase-activating protein 36
, Novel RhoGAP domain containing protein
, Rho-GTPase-activating protein like protein
, Rho GTPase-activating protein 36