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ARHGEF10L is a member of the RhoGEF family of guanine nucleotide exchange factors (GEFs) that activate Rho GTPases (Winkler et al., 2005 [PubMed 16112081]).[supplied by OMIM, Dec 2008].. Additionally we are shipping rho Guanine Nucleotide Exchange Factor (GEF) 10-Like Antibodies (12) and many more products for this protein.
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Inherited variants in ARHGEF10L and AKAP6, with potential transcriptional regulatory function and association with Epithelial ovarian cancer risk, warrant investigation in independent Epithelial ovarian cancer study populations.
In intact cells, GrinchGEF induced specifically Rho activation and enhanced RhoA-C-specific downstream effects.
ARHGEF10L is a member of the RhoGEF family of guanine nucleotide exchange factors (GEFs) that activate Rho GTPases (Winkler et al., 2005
rho guanine nucleotide exchange factor 10-like protein