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serine protease inhibitor possibly involved in modulating extracellular matrix deposition. Additionally we are shipping SERPINB7 Antibodies (61) and and many more products for this protein.
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Suggest that the down-regulation of megsin might exert beneficial effects on the diabetic kidney partly through down-regulation of p27(kip1 (show CDKN1B ELISA Kits)).
diabetic nephropathy model in triple transgenic mice overexpressing RAGE (show AGER ELISA Kits), iNOS (show NOS2 ELISA Kits) & megsin; triple-hit damage develops severe diabetic nephropathy at early age with mesangial expansion, nodule-like lesion & tubulointerstitial damage with oxidative stress
SERPINB7 mutations are related strictly to the PPKN phenotype. Our study indicates that screening for SERPINB7 mutations is useful to distinguish PPKN from other PPK (show GJB2 ELISA Kits) types and from non-PPK (show GJB2 ELISA Kits) keratinizing diseases with palmoplantar skin lesions.
Direct sequencing of SERPINB7 revealed five homozygous founder mutations (c.796C>T) and four compound heterozygous mutations in nine patients, including one novel mutation (c.122_127delTGGTCC).
Case Report: striate palmoplantar keratoderma showing transgrediens in a patient with heterozygote nonsense mutations in DSG1 (show DSG1 ELISA Kits) and SERPINB7.
Results show splice variants from the two recurrent splice-site mutations in SERPINB7, provide evidence for the pathogenicity of the mutations and suggest an in-frame deletion of exon 3 may cause NPPK and that the CD-loop could affect SERPINB7 function
These results indicate that megsin gene variants may play a role in the severity, development, and/or progression of IgAN in Northwest Chinese population
Recessive missense mutation of SERPINB7 gene was found in Japanese families diagnosed with palmoplantar keratosis.
Megsin 2093C/T TT genotype, and C25663G G allele and GG genotype were associated with the risk of IgAN in Asian population
These data clearly provide further evidence that NPPK is caused by loss-of-function mutations in SERPINB7.
megsin 2093C/T C allele may be genetic marker for IgA (show IgA ELISA Kits) nephropathy susceptibility [review]
The mean concentration of serpin B7 at 28-32 weeks was 1.5-fold higher in women with subsequent preterm deliveries compared to controls.
serine protease inhibitor possibly involved in modulating extracellular matrix deposition
serpin peptidase inhibitor, clade B (ovalbumin), member 7
, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 7
, megsin (predicted)-like
, serpin B7
, serpin peptidase inhibitor, clade B, member 7, isoform 1
, serine (or cysteine) proteinase inhibitor, clade B, member 7
, mesangium predominant gene, megsin
, serine (or cysteine) peptidase inhibitor, clade B, member 7