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SGK3 is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. Additionally we are shipping serum/glucocorticoid Regulated Kinase Family, Member 3 Antibodies (127) and and many more products for this protein.
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Mechanism of activation of SGK3 by IGF1 (show IGF1 Proteins) via the class 1 and class 3 phosphatidylinositol 3-kinases has been described.
Hence, we concluded that miR1443p, which is frequently downregulated in hepatocellular carcinoma (HCC (show FAM126A Proteins)) can inhibit proliferation, migration and repress angiogenesis by regulating SGK3 activation with PI3K (show PIK3CA Proteins) independent signal pathway, and acts as a prognostic factor for HCC (show FAM126A Proteins) patients.
SGK3 a kinase transcriptionally regulated by estrogen receptor alpha (ERalpha (show ESR1 Proteins)) in breast cancer, sustains ERalpha (show ESR1 Proteins) signaling and drives the acquired aromatase (show CYP19A1 Proteins) inhibitors resistance by protecting against endoplasmic reticulum (EnR (show LARGE Proteins)) stress-induced ERalpha (show ESR1 Proteins) downregulation and cell death through preserving SERCA2b (show ATP2A2 Proteins) function.
High SGK3 expression is associated with epithelial-mesenchymal transition in hepatocellular carcinoma.
These findings highlight the importance of the hVps34 (show PIK3C3 Proteins)-SGK3 pathway in counteracting inhibition of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signalling.
Data show that activation of serum- and glucocorticoid-regulated kinase 3 (SGK3) plays an important role in inositol polyphosphate 4-phosphatase type II (INPP4B (show INPP4B Proteins))-mediated melanoma cell proliferation.
It is unlikely that SGK3 plays a significant role for oncogenic signalling in multiple myeloma.
SGK3 is a key mediator of PDK1 (show PDK1 Proteins) activity in melanoma.
VPS34 (show PIK3C3 Proteins)-IN1 will provide a useful tool to decipher the kinase-dependent functions of Vps34 (show PIK3C3 Proteins), with acute changes in SGK3 phosphorylation and subcellular localization being new biomarkers of Vps34 (show PIK3C3 Proteins) activity
Breast cancers harboring oncogenic PIK3CA (show PIK3CA Proteins) activate SGK3 signaling while suppressing Akt (show AKT1 Proteins), indicative of oncogenic functions for both INPP4B (show INPP4B Proteins) and SGK3 in these tumors.
Taken together, these data strongly suggest that SGK3 plays a significant role in regulating podocyte function, likely by controlling the expression and activity of GSK3.
SGK1 (show SGK1 Proteins) and SGK3 are expressed in multiple microglial cell lines. SGK1 (show SGK1 Proteins) and SGK3 may play an important role in regulating microglial viability and inflammatory responses.
SGK3 is a positive regulator of KCNA5 (show KCNA5 Proteins), which is at least partially effective by abrogating the effect of Nedd4-2 (show NEDD4L Proteins).
SGK3 contributes to the regulation of store-operated calcium entry into and migration of dendritic cells.
SGK3 plays a previously unappreciated role in glucose homeostasis, likely through direct effects within pancreatic beta-cells, to stimulate proliferation and insulin (show INS Proteins) release
The study identifies SGK3 as a novel endosomal kinase that acutely regulates Na(+)/H(+) exchanger 3 (NHE3 (show SLC9A3 Proteins)) in a PI3K-dependent mechanism.
SGK3 has a subtle but significant role in the regulation of renal tubular phosphate transport and bone density.
Data suggest that SGK3 is critical for proper mast cell function.
role for SGK3 in normal postnatal hair follicle development, possibly involving effects on beta-catenin (show CTNNB1 Proteins)/Lef-1 (show LEF1 Proteins)-mediated gene transcription
SGK3 is differentially regulated in hippocampus after contextual fear conditioning & reactivation of the context-shock memory. Consolidation changes are recapitulated during reconsolidation. Retrieval-induced transcription depends on memory remoteness.
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
cytokine-independent survival kinase
, serine/threonine-protein kinase Sgk3
, serine/threonine protein kinase CISK
, serum/glucocorticoid-regulated kinase 3
, serum/glucocorticoid regulated kinase 3
, serum glucocorticoid regulated kinase 3