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SGK3 is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. Additionally we are shipping serum/glucocorticoid Regulated Kinase Family, Member 3 Antibodies (126) and many more products for this protein.
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These findings highlight the importance of the hVps34 (show PIK3C3 Proteins)-SGK3 pathway in counteracting inhibition of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signalling.
Data show that activation of serum- and glucocorticoid-regulated kinase 3 (SGK3) plays an important role in inositol polyphosphate 4-phosphatase type II (INPP4B (show INPP4B Proteins))-mediated melanoma cell proliferation.
It is unlikely that SGK3 plays a significant role for oncogenic signalling in multiple myeloma.
SGK3 is a key mediator of PDK1 (show PDK1 Proteins) activity in melanoma.
VPS34 (show PIK3C3 Proteins)-IN1 will provide a useful tool to decipher the kinase-dependent functions of Vps34 (show PIK3C3 Proteins), with acute changes in SGK3 phosphorylation and subcellular localization being new biomarkers of Vps34 (show PIK3C3 Proteins) activity
Breast cancers harboring oncogenic PIK3CA (show PIK3CA Proteins) activate SGK3 signaling while suppressing Akt (show AKT1 Proteins), indicative of oncogenic functions for both INPP4B (show INPP4B Proteins) and SGK3 in these tumors.
SGK3 is an androgen receptor (AR (show AR Proteins)) target and induces cell proliferation through the AR-SGK3-p70S6K (show RPS6KB1 Proteins)-cyclin D1 (show CCND1 Proteins) pathway in prostate cancer cells.
SGK3 is a novel regulator of K(ir)2.1.
SGK3 stability and kinase activation are regulated by the Hsp90 (show HSP90 Proteins)-Cdc37 (show CDC37 Proteins) chaperone complex.
SGK1,3 enhances the expression level of mature hERG (show KCNH2 Proteins) channels by inhibiting Nedd4-2 (show NEDD4L Proteins) as well as by promoting Rab11 (show RAB11A Proteins)-mediated hERG (show KCNH2 Proteins) recycling.
SGK1 (show SGK1 Proteins) and SGK3 are expressed in multiple microglial cell lines. SGK1 (show SGK1 Proteins) and SGK3 may play an important role in regulating microglial viability and inflammatory responses.
SGK3 is a positive regulator of KCNA5 (show KCNA5 Proteins), which is at least partially effective by abrogating the effect of Nedd4-2 (show NEDD4L Proteins).
SGK3 contributes to the regulation of store-operated calcium entry into and migration of dendritic cells.
SGK3 plays a previously unappreciated role in glucose homeostasis, likely through direct effects within pancreatic beta-cells, to stimulate proliferation and insulin (show INS Proteins) release
The study identifies SGK3 as a novel endosomal kinase that acutely regulates Na(+)/H(+) exchanger 3 (NHE3 (show SLC9A3 Proteins)) in a PI3K-dependent mechanism.
SGK3 has a subtle but significant role in the regulation of renal tubular phosphate transport and bone density.
Data suggest that SGK3 is critical for proper mast cell function.
SGK3 plays an important role in postnatal hair follicle development as illustrated by SGK3 knockout mice. The hair defect is linked to reduced proliferation and reduced nuclear accumulation of beta catenin (show CTNNB1 Proteins) in hair bulb keratinocytes.
SGK3 is differentially regulated in hippocampus after contextual fear conditioning & reactivation of the context-shock memory. Consolidation changes are recapitulated during reconsolidation. Retrieval-induced transcription depends on memory remoteness.
SGK3, and to a lesser extent SGK2 (show SGK2 Proteins), but not SGK1 (show SGK1 Proteins), increase glutamate (show GRIN1 Proteins)-induced currents by increasing the abundance of GluR1 (show GRIA1 Proteins) protein in the cell membrane
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
cytokine-independent survival kinase
, serine/threonine-protein kinase Sgk3
, serine/threonine protein kinase CISK
, serum/glucocorticoid-regulated kinase 3
, serum/glucocorticoid regulated kinase 3
, serum glucocorticoid regulated kinase 3