Perifosine (KRX-0401)

Details for Product No. ABIN412181, Supplier: Log in to see
Cell Culture (CC), Functional Studies (Func)
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Characteristics Belongs to an alkylphospholipid class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells.
Purity ≥ 99 %
Chemical Name KRX-0401
Formula C₂₅H₅₃NO₄P
Permeability Cell-permeable
Molecular Weight 462.66 g/mol
CAS-No 157716-52-4
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and moisture
Storage -20 °C
Expiry Date 24 months
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 image for Perifosine (KRX-0401) (ABIN412181) Perifosine (KRX-0401)
Product cited in: Maddigan, Truitt, Arsenault, Freywald, Allonby, Dean, Narendran, Xiang, Weng, Napper, Freywald: "EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 11, pp. 5983-94, 2011 (PubMed).