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CTSG was increased in peripheral blood mononuclear cells and muscle tissues of dermatomyositis (DM) patients, and CTSG activity was higher in the serum of DM patients
CatG can be used as a novel marker to distinguish different NK cell subsets and MARS116 is applicable to determine cell surface CatG activity by flow cytometry.
Results provide evidence that cathepsin G (GC) activates IGF-1R (show IGF1R Antibodies) by stimulating IGF-1 (show IGF1 Antibodies) release from MCF-7 cells, and that IGF-1R (show IGF1R Antibodies) activation is required for CG-induced cell aggregation.
Cleavage of the alarmins by Human mast cell chymase (show CMA1 Antibodies) and human neutrophil cathepsin G suggests a function in regulating excessive inflammation.
Data show that lactoferrin (LF (show LTF Antibodies)) increases the catalytic activity of cathepsin G (CatG) at physiological concentration.
CatG is an essential protease for regulating MHC I molecules
Patients with certain polymorphisms in the CTSG gene had lower risk for chronic postsurgical pain compared with wild-types.
These in vivo data provide, for the first time, compelling evidence of the collateral involvement of cathepsin G, NE, and proteinase 3 (show PRTN3 Antibodies) in cigarette smoke-induced tissue damage and emphysema
expression levels of ELANE (show ELANE Antibodies) and CTSG were determined by quantitative real-time PCR
Elastase and cathepsin G are elevated in the plasma of HD patients, originating from primed PMNLs. In these patients, chronic elevation of these enzymes contributes to cleavage of VE-cadherin (show CDH5 Antibodies) and possible disruption of endothelial integrity.
these findings present evidence of an arterial-specific recruitment pattern centered on CatG-instructed adhesion strengthening. The inhibition of this process could provide a novel strategy for treatment of arterial inflammation with limited side effects.
Cathepsin G activity may impair efferocytosis, which could lead to an accumulation of lesion-associated apoptotic cells and the accelerated progression of early atherosclerotic lesions to more complex lesions in Apoe (show APOE Antibodies)(-/-) mice.
SerpinB1 (show SERPINB1 Antibodies) is critical for maintaining polymorphonuclear neutrophils survival by antagonizing intracellular cathepsin G activity.
Cathepsin G-regulated release of formyl peptide receptor agonists modulate neutrophil effector functions.
NADPH oxidase (show NOX1 Antibodies) in antimicrobial host defense against A. fumigatus and B. cepacia, whereas the proteases neutrophil elastase (show ELANE Antibodies), cathepsin G, and lysosomal cysteine protease cathepsin C/ dipeptidyl peptidase I (show CTSC Antibodies) are dispensable
Cathepsin G and neutrophil elastase (show ELANE Antibodies) contribute to lung-protective immunity against mycobacterial infections in mice.
Inhibition of TGF-beta (show TGFB1 Antibodies) significantly reduces microvessel density in mammary tumor-induced bone lesions, mediated by decreased expression of both vascular endothelial growth factor (VEGF (show VEGF Antibodies)) and monocyte chemotactic protein (MCP)-1 (show CPT1B Antibodies).
neutrophil elastase (show ELANE Antibodies) and cathepsin G are inhibited by PAI-1 (show SERPINE1 Antibodies) mutants
cathepsin G activity at the tumor-bone interface plays an important role in mammary tumor-induced osteolysis through RANKL (show TNFSF11 Antibodies)
both Cat-G and PAR(4 (show F2RL3 Antibodies)) play key roles in generating and/or amplifying relapses in ulcerative colitis
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene.
, vimentin-specific protease