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despite the prominent role of NANOS3 in ovarian development, our findings suggest that NANOS3 mutations were not associated with POF (show POF1B Proteins) in the present cohort of Brazilian women.
data can be used to further elucidate the role of NANOS3 and DAZL (show DAZL Proteins) in germ cell development both in vitro and in vivo
NANOS3 has role in the acquisition of invasiveness by human lung tumour cells and propose a new mechanism of post-transcriptional regulation of epithelial-mesenchymal transition.
an inactivating missense mutation in NANOS3 has a role in primary ovarian insufficiency that involves increased primordial germ cell apoptosis during embryonic cell migration
NANOS3 mutation is one possible cause of primary ovarian insufficiency.
NANOS3 modulates essential aspects of human germ cell development perhaps during the cell cycle.
Mutations in NANOS3 exons are rare in both Chinese and Caucasian women with premature ovarian failure.
Report for the first time analysis of the NANOS3 gene in infertile males.
Study suggests that Nanos3-3'UTR has an essential role in translational control in embryo.
Report distinct posttranscriptional regulations in primordial germ cells soon after their specification, for which RNA-binding proteins such as NANOS3 would play critical functions.
cloning and functional analyses of nanos2 (show NANOS2 Proteins) and nanos3; demonstrated an evolutionarily conserved function of nanos proteins in germ cell development [nanos2 (show NANOS2 Proteins)] [nanos3]
eNOS (show NOS3 Proteins) is the main isoform influencing the initiation of caerulein-induced AP. eNOS (show NOS3 Proteins)-derived NO exerts a protective effect through actions on nonacinar cell types, most likely endothelial cells, to produce greater pancreatic microvascular blood flow.
Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population is reported.
Results suggest that Nanos3 maintains the germ cell lineage by suppressing both Bax (show BAX Proteins)-dependent and Bax (show BAX Proteins)-independent apoptotic pathways.
detection of the germ cell-specific proteins Nanos2 (show NANOS2 Proteins) and Nanos3 as markers of spermatogonia has enabled the clear dissection of complex populations of these cells as Nanos2 (show NANOS2 Proteins) was recently shown to be involved in the maintenance of stem cells
Data indicate that nanos3 function is required for the maintenance of germline stem cell (GSC (show GSC Proteins)), but not for their specification, and suggest that nanos2 (show NANOS2 Proteins) and nanos3 are partially redundant in this role.
Data show a novel interaction between zebrafish Nanos and myosin light chain II (Mylz2).
Using transgenes that compromise nos mRNA localization and translational regulation, we show that wild-type body patterning can ensue without nos mRNA localization provided that nos translation is properly modulated
Regulatory interplay between Nos (show NOS1 Proteins) and Pumilio (Pum (show MYOD1 Proteins)) could cause a small change in Pum (show MYOD1 Proteins) activity to be amplified into a large shift in the balance between GluRIIA and GluRIIB subunit synapses.
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene.
nanos homolog 3
, nanos homolog 3 (Drosophila)