Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human TGFB1 Protein expressed in CHO Cells - ABIN809732
Farges, Romeas, Melin, Pin, Lebecque, Lucchini, Bleicher, Magloire: TGF-beta1 induces accumulation of dendritic cells in the odontoblast layer. in Journal of dental research 2003
Show all 7 Pubmed References
Human TGFB1 Protein expressed in HEK-293T Cells - ABIN2039654
Munger, Harpel, Gleizes, Mazzieri, Nunes, Rifkin: Latent transforming growth factor-beta: structural features and mechanisms of activation. in Kidney international 1997
Show all 3 Pubmed References
Human TGFB1 Protein expressed in HEK-293T Cells - ABIN2039656
Loeys, Schwarze, Holm, Callewaert, Thomas, Pannu, De Backer, Oswald, Symoens, Manouvrier, Roberts, Faravelli, Greco, Pyeritz, Milewicz, Coucke, Cameron, Braverman, Byers, De Paepe, Dietz: Aneurysm syndromes caused by mutations in the TGF-beta receptor. in The New England journal of medicine 2006
Show all 3 Pubmed References
Human TGFB1 Protein expressed in HEK-293T Cells - ABIN2039655
Benke, Ágg, Szilveszter, Tarr, Nagy, Pólos, Daróczi, Merkely, Szabolcs: The role of transforming growth factor-beta in Marfan syndrome. in Cardiology journal 2013
Show all 3 Pubmed References
Human TGFB1 Protein expressed in HEK-293 Cells - ABIN805198
Huang, Zhao, Fields, Ransohoff, Zhou: Imatinib attenuates skeletal muscle dystrophy in mdx mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
Show all 2 Pubmed References
Rat (Rattus) TGFB1 Protein expressed in Escherichia coli (E. coli) - ABIN1081012
Elfayomy, Almasry, El-Tarhouny, Eldomiaty: Human umbilical cord blood-mesenchymal stem cells transplantation renovates the ovarian surface epithelium in a rat model of premature ovarian failure: Possible direct and indirect effects. in Tissue & cell 2016
Rat (Rattus) TGFB1 Protein expressed in Human Cells - ABIN2009188
Assoian, Komoriya, Meyers, Miller, Sporn: Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. in The Journal of biological chemistry 1983
Show all 4 Pubmed References
Human TGFB1 Protein expressed in HEK-293 Cells - ABIN2733505
Wang, Reece, Yang: Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart. in American journal of obstetrics and gynecology 2015
TGF-beta1 regulated pAKT (show AKT1 Proteins) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.
These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Proteins), CXCR4 (show CXCR4 Proteins), and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.
SIV infection of rhesus macaques results in the emergence of IL-17 (show IL17A Proteins)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (show IL18 Proteins) expression.
SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (show CD8A Proteins)+ T cells from mesentric lymph nodes.
transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...
The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (show LDB2 Proteins).
TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (show SMAD5 Proteins) mediated pathway.
PCSK7 (show PCSK7 Proteins) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.
TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.
TGFbeta1 plays a role in zebrafish keratocyte migration.
data presented show that Zili suppresses TGF-beta signaling by physically associating with Smad4 (show SMAD4 Proteins) and preventing the formation of Smad2 (show SMAD2 Proteins)/3/4 and Smad1 (show SMAD1 Proteins)/5/9/4 complexes
TGF-beta1 acts at multiple sites, including LH receptor (show LHCGR Proteins), 20beta-HSD (show HAL Proteins) and membrane progestin receptor-beta (show PAQR8 Proteins), to inhibit zebrafish oocyte maturation
These data suggest Pez (show PTPN14 Proteins) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.
Data show that Rock2 (show ROCK2 Proteins) acts as a negative regulator of the TGFbeta signaling pathway.
These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.
R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (show SYCP3 Proteins) serves as a vegetally enriched, intrinsic factor (show GIF Proteins) to ensure a prepared status of Smads for their activation.
the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.
Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.
TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (show SMAD4 Proteins)
sortilin (show SORT1 Proteins) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway
The C allele of TGF-beta1 869T/C polymorphism, correlated with high plasma TGF-beta1 level, represented an independent risk factor for BMS-ISR in Chinese Han patients with coronary artery disease.
Data show that tripartite motif-containing protein 33 (TRIM33 (show TRIM33 Proteins)) silencing attenuates down-regulation of MYC (show MYC Proteins) and TGF-beta signaling in response to bromodomain and extraterminal domain protein inhibitors (BETi).
The results showed that SARS (show SARS Proteins) coronavirus papain-like protease (PLPro) stimulated TGF-beta1-dependent expression of Type I collagen via activating STAT6 (show STAT6 Proteins) pathway.
The high sensitivity, specificity, and accuracy of serum and aqueous humor survivin (show BIRC5 Proteins) and TGF-B1 proteins make them promising markers for early detection and follow-up of RB patients.
Data indicate that TGFb1 and TGFb3 (show TGFB3 Proteins), but not TGFb2 (show TGFB2 Proteins), showed higher expression levels in invasive breast cancer compared to normal tissues.
To match the stimulatory effect on acid uptake, cell-to-cell coupling in NHDF-Ad and CCD (show RUNX2 Proteins)-112-CoN (show DISP1 Proteins) cells was strengthened with TGFbeta1.Importantly, the activities of stromal AE2 (show SLC4A2 Proteins) and connexin-43 (show GJA1 Proteins) do not place an energetic burden on cancer cells, allowing resources to be diverted for other activities
Three types of transforming growth factor beta 1 gene mutations, R124C, H626R and R124H, were detected in the patients and transforming growth factor beta 1 gene mutations were considered underlying factors in the molecular mechanism underlying the pathogenesis of cornea dystrophy.
this study uncovers a novel pathway by which the TGFbeta-activating integrin alphavbeta8 is expressed in the human intestine on dendritic cell subsets, which is upregulated in patients with inflammatory bowel disease
Cancer cachexia promotes the development of adipose tissue (AT) fibrosis, in association with altered transforming growth factor-beta (TGFbeta) signaling, compromising AT organization and function.
In this review, we summarize current knowledge about the WFIKKN (show WFIKKN1 Proteins) proteins and propose that they are "companion" proteins for various growth factors by providing localized and sustained presentation of TGFB proteins to their respective receptors, thus regulating the balance between the activation of Smad (show SMAD1 Proteins) and non-Smad (show SMAD1 Proteins) pathways by TGFB.
Activated TGF-beta signaling rescued miR (show MYLIP Proteins)-143-reduced FSHR (show FSHR Proteins) and intracellular signaling molecules, and miR (show MYLIP Proteins)-143-induced porcine granulosa cell apoptosis.
TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (show PTK2 Proteins)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (show PTK2 Proteins) signaling is inhibited.
this study shows that TGF-beta1 protects intestinal integrity and influences Smad (show SMAD1 Proteins) and MAPK (show MAPK1 Proteins) signal pathways in intestinal epithelium cells after TNF-alpha (show TNF Proteins) challenge
this study shows that anemonin may ameliorate LPS (show IRF6 Proteins)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (show EGFR Proteins) signaling pathways
The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.
Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (show IL10 Proteins), and IL-6 (show IL6 Proteins) in ovarian follicles are reported.
Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (show TGFB2 Proteins) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.
TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (show MAPK14 Proteins) signaling, reduces CFTR (show CFTR Proteins) expression to impair CFTR (show CFTR Proteins)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (show CFTR Proteins) mutations and ultimately would compromise male fertility.
High yield isolation of BMP-2 (show BMP2 Proteins) from bone and in vivo activity of a combination of BMP-2 (show BMP2 Proteins)/TGF-beta1.
hypoxia increased the expression of platelet-derived growth factor (PDGF (show PDGFA Proteins)) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP (show MME Proteins)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
TGF-beta1 modulates the expression of syndecan-4 (show SDC4 Proteins) in cultured vascular endothelial cells in a biphasic manner.
Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (show FGF2 Proteins) expression through the activation of AP-1 (show JUN Proteins) and NF-kappaB (show NFKB1 Proteins) in bovine mammary gland fibroblasts.
The results identify TGFB1 and ESRRA (show ESRRA Proteins) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.
the combined treatment with TGF-beta1 and BMP-7 (show BMP7 Proteins) or treatment first with TGF-beta1 followed by BMP-7 (show BMP7 Proteins) was more effective than other treatment groups in both chondrogenic differentiation and SZP (show PRG4 Proteins) secretion.
Tenascin-X (show TNXB Proteins) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.
a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).
Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.
A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.
Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.
these results demonstrated that endogenous tumor-derived TGF-beta aids in suppressing local anti-tumor immunity, resulting in tumor growth, whereas excess tumor-derived TGF-beta initially results in more rapid tumor proliferation and later growth suppression, independent of anti-tumor immunity
Results indicate that vimentin (show VIM Proteins) orchestrates the healing by controlling fibroblast proliferation, TGF-beta1-Slug signaling, and epithelial-mesenchymal transition (EMT (show ITK Proteins)) processing, and all of which in turn govern the required keratinocyte activation.
Dynamic expression and regulatory mechanism of TGF-beta signaling in chicken embryonic stem cells differentiating into spermatogonial stem cells
The results provide the first evidence that upregulation of TGFb/Smad3 (show SMAD3 Proteins) in injured arteries induces local smooth muscle cells CXCR4 (show CXCR4 Proteins) expression and cell migration, and consequently intimal hyperplasia.
These results indicated that carnosic acid (CA)attenuated oxidative stress via inhibition of Nox4 (show NOX4 Proteins) expression in TGF-beta-stimulated fibroblasts and UUO operated-kidneys, suggesting that CA may be useful for the treatment of fibrosis-related diseases
pattern of STAT (show STAT1 Proteins) indicates that possibly TGF-beta and IL-6 (show IL6 Proteins) play a crucial role in differentiation of DCs subsets and Treg/Th17 imbalance during experimental cerebral malaria (ECM (show MMRN1 Proteins)).
Ltbp4 regulates Pdgfrb (show PDGFRB Proteins) expression via TGFbeta-dependent modulation of Nrf2 (show NFE2L2 Proteins) transcription factor function.
hese evidences collectively proved that the activation of IL0 and TGFB1 protected the host from antigen-induced asthma, possibly through IL10 (show IL10 Proteins) signaling. This study shed some light on the modulations of IL10 (show IL10 Proteins) and TGFB1, and related networks to asthma progression
TGF-beta and beta-catenin (show CTNNB1 Proteins) crosstalk in proximal tubules may have a role in tubular injury in two models of chronic kidney disease
Deletion of Tgfbr2 (show TGFBR2 Proteins) in myeloid cells leads to cerebrovascular inflammation and stroke with 100% penetrance.
Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (show SMAD3 Proteins) signaling pathway in chronic heart failure .
study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.
cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (show NFKB1 Proteins), and the amelioration of disc degradation.
that prenatal tracheal occlusion increases TGF-beta/Rho kinase (show ROCK1 Proteins) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs
observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering
Smad7 (show SMAD7 Proteins) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (show NOTCH1 Proteins) signaling target in limbal epithelial stem cells.
the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b
After NOTCH1 (show NOTCH1 Proteins) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (show Vcan Proteins) and collagen II.
TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.
TGF beta is involved in the pathogenesis of tympanosclerosis.
There was significantly higher expression of TGF-beta1 and MMP-9 (show MMP9 Proteins) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.
Within the limitations of the study design, production of COMP (show COMP Proteins) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.
Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
transforming growth factor beta1
, transforming growth factor, beta 1
, transforming growth factor, beta-induced, 68kDa
, transforming growth factor-beta-induced protein ig-h3-like
, transforming growth factor beta-1-like
, transforming growth factor beta 4
, transforming growth factor beta-1
, TGF-beta 1 protein
, latency-associated peptide
, transforming growth factor, beta 1 (Camurati-Engelmann disease)
, transforming growth factor-beta-1
, TGF-beta 1
, transforming growth factor-beta 1
, transforming growth factor, beta-1
, transforming growth factor beta 1
, regulatory protein
, transforming growth factor-beta
, tgf beta
, tgf-beta 5
, transforming gorwth factor-Beta5
, transforming growth factor-B5
, transforming growth factor-beta 5
, Transforming growth factor beta-1