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Human ITGAL Protein expressed in HEK-293 Cells - ABIN2713386
De Franceschi, Peuhu, Parsons, Rissanen, Vattulainen, Salmi, Ivaska, Pouwels: Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling. in PLoS ONE 2015
Data show that integrin alphaLbeta2 (LFA-1) is oriented relative to actin retrograde flow.
These results demonstrated that histone demethylase (show MBD2 Proteins) JMJD3 regulates CD11a expression in lupus T cells by affecting the H3K27me3 levels in the ITGAL (CD11a) promoter region, and JMJD3 might thereby serve as a potential therapeutic target for SLE.
Data show a nadir of CD11a expression at 2 years of natalizumab treatment in multiple sclerosis, at the peak of incidence of progressive multifocal leukoencephalopathy, indirectly suggesting that a lack of these molecules may play a role in the onset of PML (show PML Proteins) in NTZ-treated patients.
Extracellular ISG15 (show ISG15 Proteins) signals cytokine secretion through the LFA-1 integrin receptor (CD11a/CD18 (show ITGB2 Proteins)) in natural killer cells.
Suggest possible role for lymphocyte CD11a in the pathogenesis immune thrombocytopenia.
Data show that interleukin-18 (show IL18 Proteins) was involved in the eosinophil-mediated death of colon carcinoma cells via upregulation of CD11a/CD18 (show ITGB2 Proteins) and ICAM-1 (show ICAM1 Proteins) adhesion molecules.
shear-induced CD11 (show CD1D Proteins)/CD18 (show ITGB2 Proteins) cleavage is phenotypic of neutrophilic cells, including those derived from HL60 cells
Data show that leucocyte function-associated antigen-1 (integrin alphaLbeta2), DNAX accessory molecule-1 (DNAM-1 (show CD226 Proteins)) or tumour necrosis factor (show TNF Proteins)-related apoptosis-inducing ligand (TRAIL) enhance osteoclast survival when co-cultured with activated NK cells.
LFA-1 function is regulated through conformational changes that include the modulation of ligand binding affinity and molecular extension.
the blocking of LFA-1/ICAM-1 (show ICAM1 Proteins) interaction resulted in a significant increase in the percentage of IL-17 (show IL17A Proteins)(+) T cells expanded in nonclassical monocyte/T-cell cocultures
An intracellular pool of LFA-1 in naive CD8 (show CD8A Proteins)(+) T cells plays a key role in T cell activation and differentiation.
Inhibition of LFA-1 early after sepsis prevents the loss of unactivated memory-phenotype CD8 (show CD8A Proteins) T cells but does not affect activation. LFA-1 blockade improves 7-day survival in sepsis in a lymphocyte-dependent manner.
Data show that the marker antigen CD11A- fraction of hematopoietic stem cells (HSCs) contains all functional HSC (show FUT1 Proteins) activity, with the CD11A+ fraction composed of more differentiated cells that lack long-term self-renewal activity.
competitive bone marrow-reconstitution assays revealed an essential role for CD11a in the generation of thymocytes and mature T and B cells
Through the use of interval-specific SNP haplotype analysis, we further refined the Civq1 locus and identified integrin alpha L (Itgal) as one of the causative genes for Civq1
CD11a plays a crucial role in adipose tissue inflammation by participating in T-cell infiltration and activation.
CD11a and CD11b (show ITGAM Proteins) mediate leukocyte adhesion in both arterioles and venules as well as trapping in capillaries in the lung.
LFA-1/ICAM-1 (show ICAM1 Proteins)-dependent interactions between T cells and dendritic cells play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes.
Data indicate that the dimerization of integrin alphaL and beta2 is highly dependent on gp96 (show HSP90B1 Proteins).
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
CD11 antigen-like family member A
, LFA-1 alpha
, antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide
, integrin alpha-L
, integrin gene promoter
, leukocyte adhesion glycoprotein LFA-1 alpha chain
, leukocyte function-associated molecule 1 alpha chain
, lymphocyte function-associated antigen 1
, alpha L integrin
, lymphocyte antigen 15
, lymphocyte function associated antigen 1, alpha polypeptide
, integrin LFA1
, lymphocyte function-associated antigen 1, alpha polypeptide
, antigen CD11A
, lymphocyte function-associated antigen 1, alpha
, integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)