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Human ITGAL Protein expressed in HEK-293 Cells - ABIN2713386
De Franceschi, Peuhu, Parsons, Rissanen, Vattulainen, Salmi, Ivaska, Pouwels: Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling. in PLoS ONE 2015
LFA-1 cross-linking recruits and activates FAK1 and PYK2 to phosphorylate LAT selectively on a single Y-171 site that binds to the GRB2-SKAP1 complex and limits dwell times of T-cells with dendritic cells
Data show that integrin alphaLbeta2 (LFA-1) is oriented relative to actin retrograde flow.
These results demonstrated that histone demethylase JMJD3 regulates CD11a expression in lupus T cells by affecting the H3K27me3 levels in the ITGAL (CD11a) promoter region, and JMJD3 might thereby serve as a potential therapeutic target for SLE.
Data show a nadir of CD11a expression at 2 years of natalizumab treatment in multiple sclerosis, at the peak of incidence of progressive multifocal leukoencephalopathy, indirectly suggesting that a lack of these molecules may play a role in the onset of PML in NTZ-treated patients.
Extracellular ISG15 signals cytokine secretion through the LFA-1 integrin receptor (CD11a/CD18) in natural killer cells.
Suggest possible role for lymphocyte CD11a in the pathogenesis immune thrombocytopenia.
The alphaI domain, tethered through its N-linker and a disulfide to a stable beta-ribbon pillar near the center of the platform, can undergo pivoting and tilting motions that appear buffered by N-glycan decorations that differ between alphaL and alphaX subunits.
beta2 integrins-mediated chemosensory adhesion and migration of polymorphonuclear leukocytes on the vascular graft surface, bacterial cellulose.
Data show that interleukin-18 was involved in the eosinophil-mediated death of colon carcinoma cells via upregulation of CD11a/CD18 and ICAM-1 adhesion molecules.
shear-induced CD11/CD18 cleavage is phenotypic of neutrophilic cells, including those derived from HL60 cells
Data show that leucocyte function-associated antigen-1 (integrin alphaLbeta2), DNAX accessory molecule-1 (DNAM-1) or tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) enhance osteoclast survival when co-cultured with activated NK cells.
LFA-1 function is regulated through conformational changes that include the modulation of ligand binding affinity and molecular extension.
the blocking of LFA-1/ICAM-1 interaction resulted in a significant increase in the percentage of IL-17(+) T cells expanded in nonclassical monocyte/T-cell cocultures
Studied signaling mechanisms of Lymphocyte function-associated antigen-1 (LFA-1) using NMR analysis of the dynamics of the LFA-1 I-domain.
CD11a, CD11c, and CD18 gene polymorphisms and susceptibility to Behcet's disease in Koreans.
PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton that link to triple-negative breast cancer migration.
ITGAL is overexpressed in systemic lupus erythematosus CD4+ T cells, but expression is not linked to the typical clinical and serological parameters associated with the disease.
there was reduced expression of CD11a, CD11b, and CD18 in trisomy 12 cases with NOTCH1 mutations compared with wild type.
Data indicate that CD47 in cis interactions regulate LFA-1 (integrin alphaLbeta2) and VLA-4 (integrin alpha4beta1) integrin affinity, and this process plays a substantial role in the adhesion of T-cells.
We conclude, that deficiency of CD11a expression should be added to the diagnostic criteria of AML-M7, classical DS-AML and TMD.
An intracellular pool of LFA-1 in naive CD8(+) T cells plays a key role in T cell activation and differentiation.
Inhibition of LFA-1 early after sepsis prevents the loss of unactivated memory-phenotype CD8 T cells but does not affect activation. LFA-1 blockade improves 7-day survival in sepsis in a lymphocyte-dependent manner.
Data show that the marker antigen CD11A- fraction of hematopoietic stem cells (HSCs) contains all functional HSC activity, with the CD11A+ fraction composed of more differentiated cells that lack long-term self-renewal activity.
competitive bone marrow-reconstitution assays revealed an essential role for CD11a in the generation of thymocytes and mature T and B cells
Through the use of interval-specific SNP haplotype analysis, we further refined the Civq1 locus and identified integrin alpha L (Itgal) as one of the causative genes for Civq1
CD11a plays a crucial role in adipose tissue inflammation by participating in T-cell infiltration and activation.
CD11a and CD11b mediate leukocyte adhesion in both arterioles and venules as well as trapping in capillaries in the lung.
LFA-1/ICAM-1-dependent interactions between T cells and dendritic cells play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes.
Data indicate that the dimerization of integrin alphaL and beta2 is highly dependent on gp96.
LFA-1-mediated firm adhesion under conditions of shear flow requires downstream integrin signaling, which is dependent on calcium/calmodulin and the actin cytoskeleton.
Taken together, these findings demonstrated that CD11a expression contributes to expansion and differentiation of primary CD8 T cells but may be dispensable for secondary responses to Listeria monocytogenes infection.
However, this process was pertussis toxin sensitive and dependent on the integrin LFA-1.
LFA-1 plays a key role in regulating neutrophil recruitment, CXCL2 formation and tissue injury in the pancreas. LFA-1-mediated inflammation is a downstream component of trypsinogen activation in the pathophysiology of acute pancreatitis.
peritransplant anti-LFA-1 mAb inhibits early donor-reactive memory CD8 T cell allograft infiltration and inflammation
Data show that CXCL13/CXCR5 facilitated antigen encounter and BCR signaling by promoting membrane ruffling and LFA-1-supported adhesion require a functional actin cytoskeleton and the activity of the motor protein non-muscle myosin II (NM-II).
LFA-1-induced stabilization of ARE-containing mRNAs in T cells is dependent on HuR, and occurs through the Vav-1, Rac1/2, MKK3 and p38MAPK signaling cascade
The differential importance of either alpha-integrin (Itga)L or ItgaM in governing neutrophil and T cell adhesion to VEGF-A-activated colonic endothelium was studied.
Depolymerization of F-actin in natural killer (NK)-sensitive target cells abrogates LFA-1-dependent conjugate formation and granule polarization in primary natural killer (NK) cells.
Findings indicate that LFA-1 on DCs needs to be in an inactive state to ensure optimal T-cell activation and suggest that regulation of LFA-1 activity allows DCs to actively control antigen-driven T-cell proliferation and effective immune responses.
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
CD11 antigen-like family member A
, LFA-1 alpha
, antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide
, integrin alpha-L
, integrin gene promoter
, leukocyte adhesion glycoprotein LFA-1 alpha chain
, leukocyte function-associated molecule 1 alpha chain
, lymphocyte function-associated antigen 1
, alpha L integrin
, lymphocyte antigen 15
, lymphocyte function associated antigen 1, alpha polypeptide
, integrin LFA1
, lymphocyte function-associated antigen 1, alpha polypeptide
, antigen CD11A
, lymphocyte function-associated antigen 1, alpha
, integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)