anti-Human DDX58 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended DDX58 Antibody (supplied by: Log in to see )

Antigen
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) Antibodies
  • RIG-I
  • RIGI
  • RLR-1
  • 6430573D20Rik
  • C330021E21
  • RHIV-1
  • RIG-1
  • DExD/H-box helicase 58
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
  • DEXD/H-box helicase 58
  • DDX58
  • Ddx58
Reactivity
Human, Mouse (Murine), Rat (Rattus)
178
90
31
21
17
2
2
Host
Rabbit
122
51
9
5
Clonality
Polyclonal
Conjugate
This DDX58 antibody is un-conjugated
12
8
6
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
142
72
45
42
26
15
14
8
7
7
3
2
1
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Catalog No. ABIN730663
$ 306.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN893759 IF (p) Alexa Fluor 647 Rabbit IgG Log in to see Polyclonal 0
1 ABIN893760 IF (p) Alexa Fluor 350 Rabbit IgG Log in to see Polyclonal 0
1 ABIN893762 IF (p) Alexa Fluor 555 Rabbit IgG Log in to see Polyclonal 0
1 ABIN893763 IF (p) Alexa Fluor 488 Rabbit IgG Log in to see Polyclonal 0
1 ABIN730666 IF (p) Cy3 Rabbit IgG Log in to see Polyclonal 0
1 ABIN730668 IF (p) Cy5.5 Rabbit IgG Log in to see Polyclonal 0
1 ABIN730669 IF (p) Cy7 Rabbit IgG Log in to see Polyclonal 0
1 ABIN730670 IF (p) FITC Rabbit IgG Log in to see Polyclonal 0
1 ABIN730667 IF (p) Cy5 Rabbit IgG Log in to see Polyclonal 0
1 ABIN757811 IF (p) Cy5 Rabbit IgG pThr170 Log in to see Polyclonal 0
1 ABIN757813 IF (p) Cy7 Rabbit IgG pThr170 Log in to see Polyclonal 0
1 ABIN757810 IF (p) Cy3 Rabbit IgG pThr170 Log in to see Polyclonal 0
1 ABIN757812 IF (p) Cy5.5 Rabbit IgG pThr170 Log in to see Polyclonal 0
1 ABIN757814 IF (p) FITC Rabbit IgG pThr170 Log in to see Polyclonal 0
1 ABIN877551 IF (p) Alexa Fluor 555 Rabbit IgG pThr170 Log in to see Polyclonal 0
1 ABIN877554 IF (p) Alexa Fluor 647 Rabbit IgG pThr170 Log in to see Polyclonal 0
1 ABIN877553 IF (p) Alexa Fluor 350 Rabbit IgG pThr170 Log in to see Polyclonal 0
1 ABIN877555 IF (p) Alexa Fluor 488 Rabbit IgG pThr170 Log in to see Polyclonal 0
1 ABIN2812302 IF (p) Alexa Fluor 594 Rabbit IgG Log in to see Polyclonal 0
1 ABIN2812304 IF (p) Alexa Fluor 594 Rabbit IgG pThr170 Log in to see Polyclonal 0

General

Antigen DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(178), (90), (31), (21), (17), (2), (2)
Host Rabbit
(122), (51), (9), (5)
Clonality
Polyclonal
Conjugate This DDX58 antibody is un-conjugated
(12), (8), (6), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(142), (72), (45), (42), (26), (15), (14), (8), (7), (7), (3), (2), (1)
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Product Details anti-DDX58 Antibody

Target Details DDX58 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human DDX58
Isotype IgG
Plasmids, Primers & others

Target Details DDX58

Product Details anti-DDX58 Antibody Application Details Handling Images back to top
Antigen
Alternative Name DDX58 (DDX58 Antibody Abstract)
Background

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs), IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.

Subcellular location: Cytoplasm

Synonyms: RIGI, RIG-I, RLR-1, SGMRT2, Probable ATP-dependent RNA helicase DDX58, DEAD box protein 58, RIG-I-like receptor 1, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein, DDX58

Gene ID 23586
UniProt O95786
Pathways Activation of Innate immune Response, Hepatitis C

Application Details

Product Details anti-DDX58 Antibody Target Details DDX58 Handling Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-DDX58 Antibody Target Details DDX58 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-DDX58 Antibody Target Details DDX58 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) antibody (ABIN730663) anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) antibody
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) antibody (ABIN730663) anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) antibody (Image 2)