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Human MMP2 Protein expressed in Human Cells - ABIN2002031
Brooks, Silletti, von Schalscha, Friedlander, Cheresh: Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. in Cell 1998
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Human MMP2 Protein expressed in Escherichia coli (E. coli) - ABIN1080273
Zheng, Hu, Huang, Xu, Yang, Li: In vivo bioengineered ovarian tumors based on collagen, matrigel, alginate and agarose hydrogels: a comparative study. in Biomedical materials (Bristol, England) 2015
Human MMP2 Protein expressed in HEK-293 Cells - ABIN2181511
Fernandez-Patron, Radomski, Davidge: Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. in Circulation research 1999
Show all 6 Pubmed References
study demonstrated that matrix metalloproteinase 1 (show MMP1 Proteins) and 2 might be fundamental for events related to equine tissue remodeling, which occurs during follicular development
inhibition of ECM (show MMRN1 Proteins) degradation by inhibition of matrix metalloproteinase 2 (Mmp2) to preserve the extracellular environment characteristics of young adults led to increased dendrite regeneration
Data indicate that matrix metalloproteinases mmp1 (show MMP1 Proteins) and mmp2 mutants have distinct heart phenotypes.
We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2 (show CA2 Proteins)+ as the second messenger.
Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells.
As a Wnt (show WNT4 Proteins) signaling antagonist, MMP2 cleaves the glypican (show GPC1 Proteins), reducing the ability of Dlp (show DMD Proteins) to interact with the Wnt (show WNT4 Proteins) ligand and promote its distribution.
Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila
Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.
Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes
Mmp2 expression in the developing air sac (show ADCY10 Proteins) is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling.
findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix
Mmp2 facilitates endothelial-to-hematopoietic transition via ECM (show MMRN1 Proteins) remodeling.
Dexamethasone and hydrocortisone alter expression and activity of MMP-2 and MMP-9 (show MMP9 Proteins) in the embryonic zebrafish.
Diet and exercise affect atheromatous MMP2/9 activity by modulating the systemic inflammatory milieu, with sVCAM-1, resistin, and adiponectin closely interacting with each other and with visceral fat.
calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2/TGF-beta1 (show TGFB1 Proteins) pathway.
Aneurysmal-prone factors induced HIF-1alpha (show HIF1A Proteins) can cause overexpression of MMP-2 and MMP-9 (show MMP9 Proteins) and promote aneurysmal progression.
These studies illustrated an important role of MMP2 in cognitive and motor behaviors and confirm its importance in NPC (show NPC1 Proteins) activities crucial to brain development, growth and response to and recovery from injury.
Secretagogin (show SCGN Proteins)-dependent MMP2 release from neurons regulates neuroblast migration.
matrix metalloproteinase 2 (Mmp2) transcript is a target of miR (show MLXIP Proteins)-195a-3p, and that silencing Mmp2 phenocopied the reduced proliferation and migration of MSCs. The therapeutic potential of miR (show MLXIP Proteins)-195a-3p as an angiogenesis inhibitor was also demonstrated in a laser-induced choroidal neovascularization mouse model.
developed a novel selective radiolabeled MMP2/9 inhibitor, suitable for single photon emission computed tomography (SPECT) imaging that effectively targets atherosclerotic lesions in mice
MMP-2 and MMP-9 (show MMP9 Proteins) have roles in early stages of experimental autoimmune encephalomyelitis induction; MMP-9 (show MMP9 Proteins) from an immune cell source is required in EAE for initial infiltration of leukocytes into the central nervous system
This study illustrated that tumour-derived MMP2 has at least two roles in tumour malignancy; to enhance tumour invasiveness by degrading the extracellular matrix and to enhance tumour growth by promoting vessel maturation and function.
MMP-2 and -9 expression were suppressed significantly by treatment with SB-3CT. The data demonstrated, for the first time, that SB-3CT strongly reduced corneal lymphangiogenesis and macrophage infiltration during inflammation.
MMP-2 serum level and circulating tumor cells show the potential to predict CNS metastases and overall survival in breast cancer patients; CTCs and MMP-9 (show MMP9 Proteins) serum level could be a promising therapy response marker in castration resistant prostate cancer patients
RhoGDIbeta overexpression led to downregulation of miR (show MLXIP Proteins)-200c, whereas miR (show MLXIP Proteins)-200c was able directly to target 3'-UTR of jnk2mRNA and attenuated JNK2 (show MAPK9 Proteins) protein translation, which resulted in attenuation of Sp1mRNA and protein expression in turn, inhibiting Sp1 (show PSG1 Proteins)-dependent MMP-2 transcription.
both HBEGF (show HBEGF Proteins) upregulation and apoptosis were rescued by exogenous MMP2
MMP-2 (and MMP-1 (show MMP1 Proteins) and MMP-3 (show MMP3 Proteins)) are independently associated with markers of arterial stiffening in patients with type 1 diabetes.
The results suggest that SH3GL2 (show SH3G2 Proteins) suppresses migration and invasion behaviors of glioma cells through negatively regulating STAT3 (show STAT3 Proteins)/MMP2 signaling.
MMP-2 (-1306 C/T) polymorphism is associated with exudative age-related macular degeneration development in younger males.
these results suggest that Ascochlorin inhibits cell migration and invasion by blocking FAK (show PTK2 Proteins) and JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling, resulting in reduced MMP-2 activity.
We found that overexpression of AEG-1 (show MTDH Proteins) in PTC (show F9 Proteins) was positively correlated with lymph node metastasis and MMP2/9 expression. Knockdown of AEG-1 (show MTDH Proteins) reduced the capacity of migration and invasion through downregulation of MMP2/9 in thyroid cancer cells. Furthermore, we firstly found that AEG-1 (show MTDH Proteins) interacted with MMP9 (show MMP9 Proteins) in thyroid cancer cells.
MMP2/TIMP4 (show TIMP4 Proteins) ratio is a marker of disease severity and right ventricular function as well as a predictor for survival and time to clinical worsening in idiopathic pulmonary arterial hypertension.
The aim was to examine if the serum concentrations of elastin (show ELN Proteins)-related proteins correlate to signs of cardiovascular diseases in patients with Diabetes mellitus type 2.
this study shows that differential FFAR1 (show FFAR1 Proteins) signaling is associated with gene expression or gelatinase granule release in bovine neutrophils
NADPH oxidase (show NOX1 Proteins) plays an important role in proMMP-2 expression and activation and MMP-2 mediated SMC (show DYM Proteins) proliferation occurs through the involvement of Spm (show NPC1 Proteins)-Cer (show CBLN1 Proteins)-S1P (show MBTPS1 Proteins) signaling axis under ANG II (show AGT Proteins) stimulation of PASMCs
The expression patterns of MMP1 (show MMP1 Proteins), MMP2, and MMP8 (show MMP8 Proteins) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1 (show MMP1 Proteins), MMP2, and MMP8 (show MMP8 Proteins) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1 (show MMP1 Proteins), MMP2, and MMP8 (show MMP8 Proteins) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.
The results showed that a decrease in MMP-1 (show MMP1 Proteins) and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.
Activation of cytosolic MMP-9 (show MMP9 Proteins) and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
Data indicate the involvement of PKC-alpha (show PKCa Proteins) in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Proteins) expression by NF-kappaB (show NFKB1 Proteins)-MT1-MMP (show MMP14 Proteins)-dependent and -independent pathway.
Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2; MMP-14 (show MMP14 Proteins)) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.
Adding pure bovine MMP-2 to the smooth muscle membrane suspension causes an increase in Ca(2+)-ATPase activity, but the pretreatment with TIMP-2 (show TIMP2 Proteins) inhibits the increase in the enzyme activity
A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.
MMP-14 (show MMP14 Proteins), MMP-2 and TIMP-2 (show TIMP2 Proteins) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (show MMP9 Proteins), TIMP1 (show TIMP1 Proteins), and NGAL (show LCN2 Proteins) (also MMP2 in 220 kDa complex) without proteolytic activity.
Data demonstrate for the first time that MMP2 and MMP9 (show MMP9 Proteins) are expressed in swine ovarian follicle both in theca and granulosa layers.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (show MMP9 Proteins) and MMP-2, caspase-3 (show CASP3 Proteins) and BDNF (show BDNF Proteins)
MMP-2 may play an important role in regulating MLC1 turnover in the heart under normal physiological conditions
Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.
PI3K-dependent regulation of MT1-MMP (show MMP14 Proteins) protein synthesis and subsequent activation of latent MMP-2 as critical events in neointimal hyperplasia after vascular injury.
MMP-2 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis
contribution of MMPs to the inflammatory breakdown of the blood-CSF (show CSF2 Proteins) barrier in vitro
The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 (show MMP9 Proteins) in the corpus luteum of swine during luteolysis are reported.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (show VEGFA Proteins), pro-MMP-9 (show MMP9 Proteins), MMP-2, VEGFR-1 (show FLT1 Proteins), VEGFR-2 (show KDR Proteins), and TIMP-1 (show TIMP1 Proteins), which may contribute to the development of venous stenosis.
Selenium suppressed high-fat diet-induced MMP2 over-expression in vivo by improving lipid metabolism.
Inflammatory factors such as TNF-alpha (show TNF Proteins) can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases
Results provide evidence that MMP-2 bears the potentiality to cleave alpha-DG enriched from rabbit skeletal muscle indicating that this degradation indeed might also occur in vivo.
In conclusion, MMP-2 could be responsible for the proteolysis of dystrophin (show DMD Proteins).
Castor oil polymer induces bone formation with high matrix metalloproteinase-2 expression.
MMP2 spinal cord expression is increased in cervical spondylotic myelopathy.
Ulinastatin (show AMBP Proteins) effectively inhibited the increased expression of MMP-2, MMP-3 (show MMP3 Proteins), and iNOS (show NOS2 Proteins) in degenerated NP cells induced by IL-1beta (show IL1B Proteins) in vitro.
Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 (show MMP9 Proteins) and TIMP-1 (show TIMP1 Proteins) in rabbits with acute paraquat poisoning.
The RNA interference targeting COX-2 can effectively inhibit the expression of COX-2 and MMP-2 in IL-1alpha stimulated rabbit corneal stromal cells in vitro.
Our results strongly suggest that ischaemic postconditioning may exert part of its cardioprotective effects through the inhibition of MMP-2 activity.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
, matrix metalloprotease 2
, matrix metalloproteinase
, matrix metalloproteinase 2
, 72 kDa type IV collagenase
, Gelatinase A
, matrix metalloproteinase-2
, 72 kDa gelatinase
, gelatinase A
, 72kD gelatinase
, 72kD type IV collagenase
, 72kDa gelatinase
, 72kDa type IV collagenase
, collagenase type IV-A
, matrix metalloproteinase-II
, neutrophil gelatinase
, matrix metalloproteinase 2 (72 KDa type IV collagenase)
, matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)