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anti-Human Fatty Acid Synthase Antibodies:
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Chicken Polyclonal Fatty Acid Synthase Primary Antibody for ICC, IF - ABIN152891
Gao, Bryzgalova, Hedman, Khan, Efendic, Gustafsson, Dahlman-Wright et al.: Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal ... in Molecular endocrinology (Baltimore, Md.) 2006
Show all 19 Pubmed References
Polyclonal Fatty Acid Synthase Primary Antibody for IHC (fro), IP - ABIN540416
Dridi, Ververken, Hillgartner, Arckens, Lutgarde, Van der Gucht, Cnops, Decuypere, Buyse: FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens. in American journal of physiology. Regulatory, integrative and comparative physiology 2006
Show all 5 Pubmed References
Human Polyclonal Fatty Acid Synthase Primary Antibody for IF (p), IHC (p) - ABIN687382
Zhu, Luo, Wang, Yu, Wang, Shi, Sun, Lin, Li: Inhibition of FASN reduces the synthesis of medium-chain fatty acids in goat mammary gland. in Animal : an international journal of animal bioscience 2014
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Human Monoclonal Fatty Acid Synthase Primary Antibody for IF, IHC (p) - ABIN560848
Kristiansen, Rose, Geisler, Fritzsche, Gerhardt, Lüke, Ladhoff, Knüchel, Dietel, Moch, Varga, Theurillat, Gorr, Dahl: Endogenous myoglobin in human breast cancer is a hallmark of luminal cancer phenotype. in British journal of cancer 2010
Show all 3 Pubmed References
Human Monoclonal Fatty Acid Synthase Primary Antibody for IF, ELISA - ABIN560849
Oliveras-Ferraros, Vazquez-Martin, Fernández-Real, Menendez: AMPK-sensed cellular energy state regulates the release of extracellular Fatty Acid Synthase. in Biochemical and biophysical research communications 2008
Show all 2 Pubmed References
Human Polyclonal Fatty Acid Synthase Primary Antibody for IHC (p), WB - ABIN3044520
Lu, Ma, Cai: Increased HAGLR expression promotes non-small cell lung cancer proliferation and invasion via enhanced de novo lipogenesis. in Tumour biology 2017
Human Polyclonal Fatty Acid Synthase Primary Antibody for ICC, IF - ABIN4310707
Huang, Bell, Okamura, Kim, Mohney, Guerrero-Preston, Ratovitski: Phospho-ΔNp63α/SREBF1 protein interactions: bridging cell metabolism and cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012
Fasn-1 regulates antimicrobial peptide nlp-29 expression in a WNK-1 and gck-3 dependent manner.
Genetic interactions at the cell-autonomous level, where glycolytic enzymes or Glo1 were manipulated in FASN mutant cells, revealed that this sugar-dependent size reduction is a direct consequence of MG-derived-AGE accumulation
Evaluation of FAS/FASL polymorphisms can predict lack of response to BCG immunotherapy and prevent the loss of valuable time before such alternative treatments as early cystectomy are initiated.
FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma.
HIV-1 infection increases intracellular levels of fatty acid synthase (FASN). Despite the requirement of FASN for nascent virion production, FASN activity was not required for intracellular Gag protein production, indicating that FASN dependent de novo fatty acid biosynthesis contributes to a late step of HIV-1 replication
Findings showed that FASN is upregulated in colorectal cancer cell lines that overexpress PGC-1alpha and indicated that FASN expression may enhance cancer cell proliferation by regulating antioxidant enzyme production and resistance to ROS-induced apoptosis. Further data provided evidence that FASN expression was regulated indirectly by PGC-1alpha.
Repression of FAS mRNA expression is the consequence of feedback inhibition of FAS expression by long chain fatty acyl-CoAs, which are formed by FACL3 during its upregulation by vitamin D3 in prostate cancer cells.
analysis of the expression of fatty acid synthase, Ki-67 and p53 in squamous cell carcinomas of the larynx
Fatty acid synthase (FASN) mRNA and protein overexpression were associated with unfavorable clinicopathologic factors and poor outcomes.
KRAS is associated with activation of ERK2, induction of FASN, and promotion of lipogenesis.
The study has shown that the high frequency of FASN expression in intraepithelial neoplasia (hPIN)and cancer and no expression in most structures of benign hyperplasia make it possible to use this protein as an additional marker in the differential diagnosis of prostatic neoplasms.
FASN inhibition/knockdown significantly increased the susceptibility of cisplatin-resistant cells to NK cell cytotoxicity.
FASN has a role in leucine deprivation-inhibited proliferation and apoptosis of human breast cancer cells
HER2-FASN lipogenic axis delineates a group of breast cancer patients that might benefit from treatment with therapeutic regimens containing FASN inhibitors
FASN expression is down-regulated by miR-15a and miR-16-1 in breast cancer cells, regulating cell proliferation.
These findings implicate Spot14 as a direct protein enhancer of FASN catalysis in the mammary gland during lactation when maximal MCFA production is needed.
High FASN expression is associated with prostate cancer growth.
We show that elevated levels of PPARG strongly correlate with elevation of FASN in human prostate cancer (CaP) and that high levels of PPARG/FASN and PI3K/pAKT pathway activation confer a poor prognosis.These data suggest that CaP patients could be stratified in terms of PPARG/FASN and PTEN levels to identify patients with aggressive CaP who may respond favorably to PPARG/FASN inhibition.
High FASN expression is associated with meningioma and schwannoma.
our findings show that microRNA-195 inhibits pancreatic cancer cell proliferation and invasion by regulating the fatty acid synthase/Wnt signaling pathway, suggesting a tumor suppressive role for microRNA-195 in the development and progression of pancreatic cancer. Thus, inhibiting fatty acid synthase by microRNA-195 may serve as a novel therapeutic approach for the treatment of pancreatic cancer.
Inhibition of FASN can decrease the levels of IGFBP1, and the expression, activity, and ubiquitination of HIF-1alpha. Inhibition of FASN can suppress migration, invasion and healing of hepatoma carcinoma cells by decreasing HIF-1alpha, and IGFBP1.
The involvement of SREBP-1c and ChREBP in FASN promoter histone modification.Histone acetylation affects FASN transcription by influencing ChREBP-binding carbohydrate-responsive elements.
FASN gene is a promising marker for subcutaneous fat tissue accumulation, while INSIG2 is a promising marker for FA composition
In this study, we investigated the FASN gene expression pattern and corresponding DNA methylation status in the inner layer of backfat from Jinhua pigs at different developmental stages.
calculated a 4.5 angstrom-resolution map of fatty acid synthase, and placed homologous template structures of all individual catalytic domains responsible for the cyclic elongation of fatty acid chains into the electron density
study determined fatty acid synthase crystal structure at 3.2 angstrom resolution covering five catalytic domains; structure reveals a complex architecture of alternating linkers and enzymatic domains
an unexpected link between FASN and cholesterol synthesis that appears to be required for TLR signal transduction and proinflammatory macrophage activation.
FASN regulates the pathogenicity of Th17 cells.
genetic deletion of FASN totally suppresses hepatocarcinogenesis driven by AKT and AKT/c-Met protooncogenes in mice.
Data show that nuclear factor Y (NF-Y) binds to the inverted CCAAT element (ICE) in the Fatty acid synthase (Fasn) promoter specifically in refeeding states.
study demonstrates that co-activation of AKT and c-Met induces hepatocellular carcinoma development that depends on the mTORC1/FASN pathway.
Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.
These findings suggest that activation of TSHR directly inhibits FASN expression in mature adipocytes, possibly mediated by PKA and ERK
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
FASN plays an important role in exercise-mediated cognitive enhancement, which might be associated to its role in modulating exercise-induced stimulation of neurogenesis.
FASN is essential for the development, functional competence, and maintenance of the lactating mammary gland.
Gamma-tocotrienol showed attenuation of triglyceride through effect on fatty acid synthase, sterol regulatory element-binding transcription factor 1, stearoyl CoA desaturase 1, and carnitine palmitoyl transferase 1A gene expression in Hepa 1-6 cells.
Upregulation of host hepatic fatty acid synthase correlates with hepatitis B virus replication.
In vivo studies using germline (Creb1(-/-) ) and lung epithelial-specific (Creb1(EpiDelta/Delta) ) Creb1 knockout mice showed strongly reduced Scd1, but not Fasn gene expression and protein levels in lung epithelial cells.
Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2.
fatty acid synthase (Fasn), the key enzyme of de novo lipogenesis, is highly active in adult neural stem and progenitor cells and conditional deletion of Fasn in mouse NSPCs impairs adult neurogenesis
Kr-pok (kidney cancer-related POZ domain and Kruppel-like protein) activates transcription of the FASN gene.
FAS deficiency blocked the generation of palmitoylated Mucin 2, which must be S-palmitoylated at its N terminus for proper secretion and function.
We observed that increased melanoma progression is associated with enhanced Cav-1 and FASN expression in tumors from HFD mice.
Fatty acid synthase modulates homeostatic responses to myocardial stress
These findings pertinent to the etiology of tumor metabolism also underscore the key role of the Sonic hedgehog-->E2F1-->FASN axis in regulating de novo lipid synthesis in cancers.
FASN single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.
g.841G>C SNP of FASN gene is associated with fatty acid composition in beef cattle.
Results indicate that Fatty acid synthase (FASN) may be used as a candidate gene affecting intramuscular fat content in Datong yaks.
It was suggested that two cattle breeds have an advantage in terms of genotype and haplotype distribution of the FASN gene; a single polymorphism might be a potential marker for breed discrimination.
study evaluated the contributions of polymorphisms of FASN and SCD genes on fatty acid composition in muscle in two different populations: 1189 and 1058 Japanese Black cattle from the Miyagi and the Yamagata populations
The five exonic single nucleotide polymorphisms of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents.
Results suggest that SCD and FASN are strong candidate genes influencing fatty acid composition in beef cattle.
The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.
In ruminants, FASN may be regulated between the ratio between two transcripts. The small transcript is mostly produced in tissues with low fatty acid synthesis.
Polymorphisms within the FASN gene are associated with milk-fat content.
SNPs in the FASN gene are associated with variation in the fatty acid composition of adipose fat and milk fat.
The four exons in FASN that encode for the TE domain were sequenced, and three SNPs, AF285607:g.17924A>G, g.18663T>C and g.18727C>T, were identified.
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence.
Results suggest that the mutations may contribute to the characteristic fatty acid composition of Japanese Black beef.
The results suggested that LXR regulates FASN promoter activity through direct interaction with the LXR response element as well as through increasing SREBP1 abundance.
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
fatty acid synthase
, fatty acid synthase Fas
, Fatty acid synthase Fas
, Fatty Acid SyNthase family member (fasn-1)
, fatty-acid synthase
, fatty-acid synthase II
, fatty-acid synthase fas
, fatty acid synthetase
, short chain dehydrogenase/reductase family 27X, member 1